Preface This book is written for students who are taking their first and perhaps their only course in biochemistry, whether as undergraduates or as graduate students. I undertook these tasks because I want to convey to students my picture of what this science has recently become. Biochemistry is no longer a mere catalogueof the biological occurrence and enzymatic reactions of a large number of organic compounds. In the last few years it has acquired, along with many new facts, a set of organizing principles which have made it a much simpler field to comprehend, and, at the same time, a more powerful way of analyzing many important problems in biology. Biochemistry has been undergoing such a transition, stimulated by new experimental findings and new insights. Among these are the recognition of the principles of energy transfer in cells, the mechanisms by which the major metabolic pathways are regulated, the importance of membranes, ribosome’s, and other ultra structural elements of cells in their molecular activities and the far reaching conclusion that the amino acid sequence determines the three dimensional conformation of protein molecules and thus their biological functions. This book is concerned primarily with biochemistry at clinical level, where its organizing principles are most clearly evident. Central concepts are emphasized rather than an encyclopaedic treatment of biochemical details. Biochemicals has many new frontiers today. I have tried to sketch out some of the most promising in chapters on regulation of protein synthesis and its role in cell differentiation, the molecular basis of self assembly and morphogenesis, and the origin of life. I hope they will serve to acquaint students with some of the biochemistry of the future. This is a comprehensive book on extension education in which all the aspect of the extension education have explained with all type of examples from the field. There are very few countries of the world where so many experiments have been done on the application for animal husbandry and rural development as in India. The structure and function of the planning commission and the method of decentralized planning through Panchayats have been given in this book. The effective management of extension organization is crucial for the success of its programme. Creating awareness amongst the students and make them participated in the various programme, the most urgent need of the day has also been included in the book. Wherever, there is need for educating and motivating the people, student, scientists, extension professional shall find the book very useful.