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The flora of India is diverse and abundant. Synthetic medications are known to be expensive, and even dangerous. Herbal remedies, on the other hand, are less harmful, less expensive, and environmentally beneficial. They have also been used by the populace for many generations. They have also been applied to routine issues in animal healthcare. Plants are the source of 25% of the medications administered globally. The biological action of medicinal plants is due to the presence of phytochemicals or plant secondary metabolites, which are byproducts of secondary metabolism that continue with their vital primary metabolism. This book deals with a comprehensive review of conditions of veterinary importance where medicinal plant species are involved. The botanical names, distribution, plant part used, bioactive principles, and pharmacological actions are mentioned. Also, selected veterinary herbal formulations are provided. This book will contribute to the knowledge of medicinal plants from several aspects like their natural properties and pharmacological effects. This compilation has 20 chapters covering medicinal plants effective in various diseases and conditions of veterinary importance. This book will be helpful to researchers, drug developers, drug discoverers and anybody else attempting to use botanicals to alleviate animal discomfort.

Introduction Plants have been used for ages as animal and human health cures. Ethnoveterinary medicines, a phrase that primarily refers to folk skills, beliefs, knowledge, practices, and procedures related to animal health and the treatment of various disorders in rural regions, have acknowledged the ability of plants to combat a variety of diseases. The World Health Organisation (WHO) defines traditional medicine, also referred to as herbal medicine, as “When it comes to maintaining health and preventing, diagnosing, improving, or treating physical and mental illnesses, the entirety of the knowledge, abilities, and practices derived from indigenous theories, beliefs, and experiences whether or not they can be explained as illness”. Approximately 25% of contemporary medications are derived from plants that were once used in traditional medicine. The use of traditional medicine and its confirmation could result in the creation and discovery of more novel medications.

Introduction Diabetes mellitus is a disease the related to metabolism of the body and malfunctioning of pancreas. Pancreas having alpha and beta cells where alpha cells produce enzymes needed for the digestion and beta cells mainly produce insulin. One important component that regulates blood glucose (sugar) levels and how it is delivered to the body’s cells is Insulin. The body’s cells run out of their primary energy source when insulin levels are low. Insulin voices the body’s cells to engross glucose from the bloodstream. Without an satisfactory amount of insulin glucose cannot invade the cells and so it accrues in the blood, triggering hyperglycemia (high blood sugar). In retort to this ostensible starvation, the body starts flouting down supplies of protein & fat for energy, producing weight loss contempt a ravening appetite. The body efforts to remove the extra glucose by micturating. To avoid thirst, the dog drinks more and more water. Type I increased diabetes mellitus outcomes from completeobliterat ion of the insulin-creating beta cells. In dogs, this is the most prevalent kind of diabetes. As the name implies, insulin injections are necessary to balance blood sugar in dogs with this kind of diabetes.

Tumour in Domestic Animals Tumours in domestic animals, much like in humans, can occur in various tissues and organs. These can range from benign growths (non-cancerous) to malignant tumors or cancerous. Their causes, types, diagnosis, and treatments depend on the animal species, breed, age, and environmental factors. Common tumours in dogs are mammary tumours, skin tumours, lymphoma, osteosarcoma and hemangiosarcoma. In cats lymphoma, squamous cell carcinoma, mammary tumors and fibrosarcomas are reported. In cattle, squamous cell carcinoma, lymphosarcoma and papilloma are common. In horses, sarcoids, melanomas and squamous cell carcinoma are common. In small ruminants (sheep and goats) lymphoma and skin tumours are reported. In pigs, lymphoma and melanomas are commonly reported. Diagnosis of cancers are done by physical examination, cytology, biopsy, imaging: X-rays, ultrasound, CT, MRI and blood Tests.

Introduction Arthritis, a condition characterized by inflammation of the joints, is prevalent among livestock species, particularly in older animals or those subjected to intensive farming conditions. It results in pain, reduced mobility, and diminished productivity. Herbal plants with anti-inflammatory and analgesic qualities are being investigated as a result of the increased interest in natural therapies, even if treatments like non-steroidal anti-inflammatory medications (NSAIDs) and corticosteroids have been utilized to manage arthritis in livestock. This chapter addresses the use of herbal plants to treat arthritis in cattle, including a summary of the best plant-based remedies, their modes of action, and the scientific data that backs them up. Pathophysiology of Arthritis in Livestock Arthritis in livestock is primarily caused by joint degeneration, trauma, infection, or autoimmune disorders. The inflammation of the synovial membrane leads to the discharge of cytokines that cause inflammation, which degrade cartilage and cause pain. The condition significantly impacts the animal’s ability to move, affecting their overall well-being and productivity. In farmed animals, arthritis can lead to decreased milk production, reduced growth rates, and compromised meat quality, thus representing a significant economic loss.

The therapeutic potential of plants and its parts has been explored since ancient times and has been used for the well being of humans as well as animals. In the era of emergence of multi drug resistant bacteria modern research aims to find out alternative therapeutic approaches preferably from herbal source to combat the infection. Medicinal plants owing to their antibacterial, antioxidant, anti inflammatory capabilities have been used against many bacterial infections in livestock and companion animals. Ethnoveterinary practices have been documented against bacterial diseases in animals like mastitis, colibacillosis, Salmonellosis, pyoderma, otitis externa, gastrointestinal infection, pneumonia and many others, some of which are enlisted below. Bovine mastitis, predominantly a bacterial disease continues to threaten the dairy sector as it inflicts great economic losses to the dairy farmers. The disease caused by more than 200 species of bacteria is characterized by inflammation of the mammary gland with physical and chemical changes in the milk and pathological changes in the glandular tissue. There is a significant reduction in the milk yield and many times it’s accompanied with abnormalities in the udder, milk and the cow. In addition to this, milk from affected animals may harbor the organisms which are potentially pathogenic to humans. Use of antibiotics is a common practice to cure mastitis.

Viral Diseases in Domestic Animals Viral diseases significantly impact the health and productivity of domestic animals, including livestock and companion animals, leading to substantial economic and emotional costs. In livestock, diseases like Foot-and-Mouth Disease (FMD) and Peste des Petits Ruminants (PPR) cause severe production losses in terms of milk, meat, and wool. Similarly, in poultry, Newcastle disease and Avian Influenza outbreaks result in high mortality and disruptions to egg production. Among companion animals, viruses such as Canine Distemper and Feline Leukemia Virus (FeLV) lead to serious morbidity and reduced quality of life. Current control measures rely heavily on vaccination and biosecurity practices, but the lack of effective antiviral treatments, coupled with the emergence of drug-resistant strains, underscores the need for novel therapeutic approaches. Medicinal plants with antiviral properties have garnered significant interest as sustainable and holistic solutions. Plantderived bioactive compounds offer a dual advantage of modulating immune responses and directly targeting viral pathogens, making them a promising area of research for the management of viral diseases in both livestock and pet animals.

Introduction The use of medicinal plants for the treatment of diseases is a practice that spans centuries. In recent years, there has been a growing interest in using herbal remedies for treating fungal infections in livestock and animals. Fungal infections, caused by pathogenic fungi such as Aspergillus, Candida, Dermatophytes, and Mucor, can lead to significant health issues in animals, affecting both domestic and wild species. These infections often manifest as skin diseases, respiratory illnesses, gastrointestinal problems, and systemic infections, and can even lead to death if left untreated. While antifungal drugs are commonly used to manage these infections, concerns about drug resistance, toxicity, and sustainability have encouraged the exploration of alternative therapeutic options, particularly herbal medicine. This chapter explores the potential of medicinal plants used as antifungal agents in livestock and animals, highlighting their efficacy, safety, and practical applications.

Introduction Helminths are a group of internal parasites of animals and human beings that usually infest gastrointestinal tract that feed from the host which provides protection to the parasite. The infestation cause loss of blood and nutrients from the host, making it weak, and vulnerable to other infections. There can be injury to other organs due to the migration of different stages of the parasite, formation of cysts or secretion of toxins that can cause damage. The heminths belong to two phyla including nemathelminthes which are round worms and Platyhelminthes that has flukes, and tapeworms. Nematodes are round worms who have a resistant cuticle and most of them have separate sexes with direct or indirect life cycle. The major nematodes include Ascarids, Strongyles, strongyloides, Trichostrongyles, Filarids, Trichuris etc. Tape worms have a flat body with a head or scolex, neck and strobili having proglottids. They are hermaphrodites and the proglottids contain reproductive organs. They require more than one host for completion of life cycle. The flukes are ususally leaf like , unsegmented and have suckers that help them to attach to the internal organs of the host. They also have a life cycle in more than one host.

The control of external parasites and the pertinent disease vectors using chemicals is riddled with various issues and hence there is a huge demand for alternative approaches. Natural products, being a prominent resource for poor farmers, can majorly serve as a cheaper, environment friendly and sustainable alternative. Further, ethno-veterinary and traditional knowledge has provided a diverse array of plants, which need to be validated for their repellent, insecticidal and acaricidal activities to claim their effect against external parasites. Besides, phytochemical study of these therapeutic plants has progressively revealed the existence of a variety of bioactive components in these plant derived extracts, catering to their efficacy against external parasites. External Parasites in Domestic Animals External parasites, also known as ectoparasites are organisms that live on the surface of domestic animals, feeding on their blood or skin. Fleas, ticks, mites, lice and flies are among the most common external parasites. These parasites can cause significant health issues in animals including discomfort, skin irritation and even severe diseases. Infestations can lead to conditions such as dermatitis, anemia and secondary infections. Moreover, many external parasites are vectors for serious diseases that can affect both animals and humans. Hence, effective management of these parasites is essential to ensure the health and well-being of domestic animals.

Our digestive structure is not only just a food handle centre. It’s a foundation of fitness, moving everything from our immunity to mental well-being. A fit gut aids in the digesting and assimilation of nutrients supports a healthy and strong immunity, and helps in the effective elimination of waste. Asserting good gut fitness is critical because it can influence our whole body’s health, prevent chronic afflictions, and develop value of growth. Plants have been second-hand for curative purposes for thousands of years, and many up-todate cures are still coming from plant compounds. In this chapter, we will study some commonly used medicinal plants used to treat common digestive system diseases, along with associated ethnomedicinal details. 1. Diarrohea About the condition/Definition- Loose, watery and possibly more-frequent passage of stool is called diarrohea. Feeling of urgent need of frequent bowel movement in a day. Etiology- A few causes include infections, diseases, and food intolerances. Rotavirus, norovirus, viral gastroenteritis; salmonella, E. coli; giardiasis, amoebiasis and food intolerance are few important causes of diarrohea. Symptoms- The symptoms include a strong desire to have bowel movement and frequent loose, watery feces. Occasionally linked to cramps, bloating, thirst, nausea, and abdominal pain

Cardiovascular System Disorders in Domestic Animals Cardiovascular system disorders in domestic animals include a range ofM conditions that affect the heart (pericardium, myocardium, endocardium), veins, arteries and lymphatic vessels. Infectious disorders like Heartworms (Dirofilaria immitis, vegetative endocarditis in pigs, equine viral arteritis). Patency of the foramen ovale, interventricular foramena, patent ductus arteriosus, persistence of the right aortic arch, coarctation of the aorta, transposition of the aorta, congenital aneurysm, pulmonic stenosis, subaortic stenosis, ectopia cardis, acardia, and diplocardia are examples of congenital and developmental disorders that can result in these conditions. Traumatic disorders like Traumatic reticulopericarditis and cardiac failure. Degenerative diseases like fatty and hyaline degeneration. Inflammatory disorders like pericarditis, myocarditis, endocarditis and phlebitis may also lead to cardiovascular system disorders. Some tumours associated with the cardiovascular system like rhabdomyosarcoma, fibroma and myxofibroma also cause cardiovascular system disorders.

Respiratory tract disorders in domestic animals The respiratory system is vital for efficient oxygen exchange, metabolic function, and overall health. Respiratory tract disorders in livestock speciesare among the most significant health challenges, leading to  economic losses in terms of reduced productivity, treatment costs, and mortality. Thesedisorders can affect the upper respiratory tract (URT), lower respiratory tract  (LRT), or both. Overview of common respiratory diseases in livestock, their aetiology, clinical manifestations, pathophysiology, diagnostic approaches, and management strategies are summarized as follows: - 1. Bovine Respiratory Disease Complex (BRDC) ? Species affected: Cattle ? Etiology: Multifactorial; involves viruses (Bovine herpesvirus-1, Bovine respiratory syncytial virus, Parainfluenza-3, Bovine viral diarrhea virus), bacteria (Mannheimia haemolytica, Pasteurella multocida, Mycoplasma bovis), and environmental stressors

The kidney plays a role in controlling the volume of different bodily fluids, fluid osmolality, acid-base balance, toxin elimination, and different electrolyte concentrations. The glomerulus filters one-fifth of the volume of blood that enters the kidneys. Among the compounds that are reabsorbed include amino acids, salt, bicarbonate, glucose, and solute-free water. Among the chemicals that are released are ammonium, potassium, hydrogen, and uric acid. The kidneys maintain homeostasis, eliminate metabolic waste products like uric acid, urea, creatinine and ammonia, regulate extracellular fluid volume, blood pressure (via the rennin-angiotensin system) and controlling systemic pH (via regulation of H+ and HCO3- concentration). Among various kidney diseases, especially chronic kidney disease (CKD) is a slow loss of kidney function in which, kidney dysfunction is present for more than three months. There are six progressive stages of CKD i.e. stages 1, 2, 3a, 3b, 4 and 5. The stages are based on the results of glomerular filtration rate (GFR) test (1). In stage 1 there is mild kidney damage, while in stage 5 kidneys lost their working capacity. Chronic kidney disease (CKD) is a worldwide health issue that is becoming more prevalent in both developed and developing nations. It typically affects adults. .

Nervous system Disorders in Domestic Animals Nervous system disorders in domestic animals encompass a range of conditions that affect the brain, peripheral nerves, and spinal cord. These disorders can result in a variety of clinical signs, depending on the area of the nervous system involved. Infectious disorders like rabies, canine distemper, toxoplasmosis, listeriosis. Congenital and developmental disorders like hydrocephalus, cerebellar hypoplasia and chiari-like malformation can cause these disorders. Traumatic and degenerative disorders like Intervertebral Disc Disease. Degenerative myelopathy, metabolic and toxic disorders like hepatic encephalopathy, hypocalcemia, lead poisoning, organophosphate toxicity, autoimmune and inflammatory disorders like meningitis and meningoencephalitis may also lead to nervous system disorders. Some tumours associated with nervous system like meningiomas and peripheral nerve sheathtumours also cause nervous system disorders.  

Introduction Serving as the primary biological barrier, the skin aids in immunological responses and provides protection against environmental pollutants and microorganisms, dehydration, and mechanical harm. The skin’s epidermis is made up of stratified and multilayered epithelial cells that, via a strictly controlled balance between terminal differentiation and cell proliferation, undergo lifelong self-renewal. One of the main causes of a wide range of skin conditions is the upset of this equilibrium. Mycoses in humans and animals are prevalent worldwide. These diseases can arise as a result of a number of physiological and environmental factors, such as the effectiveness of the immune system of the recipient and the amount of fungi in the environment. Companion animal dermatoses rank among the most common reasons for clinic visits in day-to-day veterinary practice.

Introduction:The phenomenon of reproduction is an important aspect, which needs special attention in livestock farming to achieve optimum productivity and increase the economic status of the farmers. Variousgynaecological problems like anestrus, repeat breeding, endometritis,  retention of placenta, etc reduce thereproductive performance in farm animals. Besides indirect reducing the milk yield, it also creates financial burden on the farmers due to high cost of therapeutic drugs prescribed for their treatment. The use of various hormonal preparations and antibiotics has been critical in treating these disorders inthe farm animals. However, herbal treatments render a holistic approach to manage the reproductive problems with minimalcost and no side effects. 1. Name of the condition: Anestrous About the condition/definition: Anestrus is a reproductive cycle dysfunction in which an animal does not display the obvious symptoms of estrus. It is one of the major limiting factor in achieving better reproductive performance in farm animals. Etiology and pathogenesis: Expression of estrus is controlled by secretion of reproductive hormones. Any disturbance in their secretion due to the effect of either ofSeason, stress, uterine diseases, poor management techniques, inadequate nourishment, etc., delays the process.The animals with smooth non-functional ovary are said to true anestrous, whereas absence of estrus due to retained CL on ovary due to uterine pathology are false anestrous.

Herbal galactagogues are medicinal plants used to stimulate, sustain, and boost milk production. Several plants known for their galactagogue activity are being used traditionally in many cultures to stimulate milk production in animals. However, there is a knowledge gap regarding the safety and efficacy of these medicinal plants. Moreover, the mechanism of action of the herbal constituents present in these plants is not yet elucidated. Although, many herbal galactagogues have been reported as safe in domestic animals and can be used as food supplements in the dairy industry. Nowadays, the use of plantderived supplements has increased in the dairy sector promoting a new trend of organic dairy farming. Traditional remedies being used for increasing milk production in animals often incorporate herbal treatments, mainly comprising of the following important herbs [1-8]:

Feed additives like antibiotics, hormones are successfully employed in chicken production along with basic minerals, vitamins, and nutrients. Because of worries about antibiotic residues in animal tissues and the resulting development of bacterial resistance, the use of antibiotics as growth promoters (AGP) in cattle was outlawed in 2005. Given the rising concerns about antibiotic use and its involvement in antibiotic resistance, the use of plant-based chemicals in animal feed has become essential. Phytogenic feed additives, which are made from plants and their secondary metabolites, are becoming more and more popular as a result of the search for sustainable farming methods. These natural growth promoters are seen as alternatives to synthetic chemicals, which are often associated with adverse environmental and health impacts. The usage of plant additions, also known as phytobiotics, have existed since the beginning of time, when people and farm animals were treated and prevented with herbs. The unique qualities of herbs and plant additions were effectively utilised by the ancient Greek, Egyptian, Roman, and Chinese civilisations. Phytogenic feed additives offer multiple benefits for livestock, including enhancing growth, improving immunity, supporting digestion, and promoting overall animal health. Water or alcohol extracts derived from plant additions, whether fresh or dried, fermented, or freeze-dried, can be used in poultry practices.

Wound in Domestic Animals A wound is defined as a break in the continuity of the skin, mucous membrane, or tissue surface that can result from physical, chemical, or biological agents. India has a diverse variety of livestock breeds, extensive countryside with vast grazing lands, and widespread use of livestock. The significant population of stray animals, including dogs, cats, and cattle, as well as the increase in pet ownership, make wounds in animals a commonly encountered condition. Wounds in animals can be a frustrating issue for both pets and productive animals, and this can also be a challenge for their owners. For instance, bleeding at the wound site from sudden cuts and bites can cause panic and distress among animal owners. Wounds can become complicated, as animals may lick, scratch, or otherwise irritate them, leading to infections, especially when they are soiled. Additionally, fly infestation and maggots, common in various temperate regions of India, further complicate the wound healing process. An unattended wound can quickly escalate to a severe microbial infection, which may lead to septicemia, maggot infestation, and can even become fatal for the animal. The cost of treating wounds in production animals, including expenses for antibiotics, can impose an economic burden on farmers. Common causes of wounds in domestic animals include penetrating injuries from horns, stamping injuries caused by mothers or other adult animals in tightly packed barns, tightened nose ropes, barbed wire injuries at the brisket region (in horses and cattle), and wet sores on the inner surfaces of the shoulder and groin in cattle due to friction and lack of air and sunlight exposure.

Medicinal Plants for Arsenic Toxicity Name of the Condition- Nephrotoxicity About the condition/Definition- Intoxication of arsenic (arsenite or arsenate) result in renal impairment which is marked by a significant increase in the levels of creatinine, urea, uric acid and decline in levels of plasma protein profile especially albumin level in body. Etiology- Nephrotoxicity results from arsenic damages mitochondria, which results in the excessive production of reactive oxygen species (ROS), a decline in ATP, and a suppression of respiratory activities along with dramatic alterations in the incidence of cellular growth. There is acute inflammation and the development of tubular necrosis, which lowers the glomerular filtration rate (GFR). Symptoms- Phosphaturia (Fanconi syndrome), aminoaciduria, proteinuria and glycosuria along with progressive drop of renal function. Pathogenesis- Arsenic produces renal damage by reducing mitochondrial complex function and elevating cellular ROS levels which directly damages renal cells. Membrane lipid peroxidation and protein oxidation by ROS, which results in complete loss of membrane potential and mitochondrial swelling. General treatment- Acute arsenic intoxication can be counter by using chelating agents like DMSA, DMPS and BAL, fluid therapy, forced dieresis & dialysis.