Indigenous and local peoples throughout the world have from time immemorial been sustainably interacting with nature to maintain their life support systems. This process has resulted in long-term accumulation of rich biocultural diversity. Many indigenous and long-resident communities, including those living in fragile and stressful environments, have developed adaptive practices, sustainable regimes, and location-specific traditional food systems that maintain the biocultural diversity of their ecosystems. Today this diversity is considered an essential component in maintaining the earth’s life-sustaining processes. However, global environmental and societal change is threatening this biocultural capital. Unprecedented changes in social-ecological systems due to anthropogenic and climatic factors have raised concerns over the sustainability of the food systems of many indigenous and local communities and, ultimately, of their cultures and the ecosystems they inhabit. Scholars, policymakers and governments of many countries have started to recognize the impacts of biocultural loss on indigenous and local peoples’ food systems, their health and well-being, and even their own identities.