Preface Plants are an integral part of life in many indigenous communities. Interaction between man and native plants is of paramount importance and mankind is already reaping the harvest of past endeavours. Cultures around the world rely heavily on the use of plants in all aspects of daily life like food, fodder, medicine, fuel, timber, shelter, rituals, etc. This intimate relationship between plants and humans referred to as ‘ethnobotany’ has its origin in antiquity and still is the mainstay of more than three quarters of the world population in developing countries both as need-based and culture-based application. The plant-based functional knowledge system has been developed, preserved and refined by generations of people through trial, error, observation, continuous interaction, empirical reasoning and even experimentation. This dynamic system has close links with culture, civilization and religious practices of the communities. Transition from hunter-gatherer to agricultural societies indicates an antecedent period of intensification and increasing sedentism. With the advent of human civilization, these indigenous relationships gave birth to a number of offshoots of ethnobotany including ethonomedicine on which about 80% of the world’s population in developing countries depends. Even in the developed countries, 25% of the medical drugs are based on plants and their derivative. Humans have achieved some notable successes in ethono-pharmacology; the interdisciplinary scientific exploration of biologically active agents traditionally employed and observed by man is providing alternative templates for the development of new pharmaceutical products. At present, a multifaceted in drug discovery from medicinal plants continues to unravel novel and important cues against various pharmacological targets including cancer, HIV/AIDS, Alzheimer’s, malaria, and inflammation. Several plant-based natural product drugs have found their way into the commercial medicines as dietary supplements or as chemo-preventive agents while others are currently under clinical trials. This book gives an insight into the novel approach of integrated drug discovery, where traditional wisdom and traditional documented use can synergize with drug discovery from plant sources.

Abstract Ethnobotany as an academic discipline surfaced in the 19th century. Traditional medicine is used globally and is of rapidly growing economic importance. In developing countries, traditional medicine is often the only accessible and affordable treatment available. The chapter deals with importance of plants in the life of people, value of collecting the plant samples and adding knowledge to plants based on their economic potential and issues related to ethnopharmacology. Keywords: Ethobotany, Ethnopharmacology, Drug discovery, Research ethics.

Abstract The Himalaya is one of the youngest and the richest mountain ecosystems encompassed with a variety of species of both flora and fauna. Varying in climatic conditions coupled with altitudinal gradients and unique topography leads to the formation of different types of forests, which varies from tropical to the temperate and alpine to no timber line zone and snow-clad meadows. The present study aimed to investigate the potential of medicinal plants growing in valleys and mountains of district Doda to cure various ailments of the local inhabitants including animal health care. A total of 113 species belonging to 104 genera and 55 families of angiosperms, gymnosperms and cryptogams (lycophytes and ferns) were recorded and reviewed from published documents used for treatment of different diseases in the regions. Out of the total 113 species, 17 species were of trees, 14 species were shrubs, 78 types of herbaceous plants and 4 species of climbers. Asteraceae, Lamiaceae, Rosaceae, Ranunculaceae, Polygonaceae, Solanaceae, Apiaceae, Pinaceae, Fabaceae and Berberidaceae were recorded as the dominant families of the study area. The data were collected while interacting with local people as they possess rich traditional knowledge regarding the use of different herbal plants and medicine.

Abstract Sikkim is part of the eastern Himalayan hotspot. Rich biological diversity of the region is owing to its wide range of topography, varied climatic condition and high annual precipitation, inhabited by three major ethnic communities, the Lepchas, Bhutias and Nepalese. With its unique ethno-cultural diversity and equally rich Phyto-diversity, the region holds an immense ethno-botanical knowledge and potential. The collection of food, fodder, fuel wood, timber, herbs for folk medicine from wild is an integral and deep-rooted cultural component and for sustaining socio-economic condition of the people. Medicinal plants of this region have potential for value addition as well as domestication. The folk medicine practices of three ethnic groups are different, but in general there are strong beliefs system in relation of folk medicine with supernatural forces and deities; local people consider its mountain peaks, forest, lakes as sacred hence it helps in sustainable management of its natural resources traditionally. Developments activities, urbanization, overexploitation of important plants and not giving due importance to the traditional knowledge in the past decades leads to the potential depletion in wild and that bring concern for their conservation. A proper strategic plan is needed for conservation of these valuable resources and promoting the indigenous traditional knowledge for sustainable development. Conservation-linked with people participation has been initiated in Sikkim through Sikkim State biodiversity board (SSBB), with its biodiversity management committees (BMCs), and local activist and stakeholders. The research institution of the region and researcher from outside has contributed immensely in documentations of the ethno-botanical knowledge and phyto-diversity of this region. This chapter reviews the current status of traditional ethno-botanical knowledge system of Sikkim state and highlights the current scenario of biological diversity; conservation practices, threats and challenges.

Abstract Asteraceae, one of the largest families of flowering plants, is of worldwide distribution and inhabits almost every environment except Antarctica. The family exhibits various life forms and is known to harbour a wide variety of phytochemicals. The study aimed at systematically documenting the precious ethnobotanical knowledge (ethnomedicinal, ethnotoxic and wild edible plants) of Asteraceae in district Udhampur. A total of 42 infomants between the age group 21-90 years were interviewed and 28 plant species of Asteraceae belonging to 26 genera were observed to be of ethnobotanical significance in district Udhampur. All the taxa were growing in wild and majority of them were herbs. The ethnomedicinal formulations were prepared in the form of paste, decoction, powder, etc which were found to be effective against plethora of ailments. The ethnotoxic plants were observed to exert their adverse effects by causing different ailments or diseases. The present study may serve as a base line data for further research and will go a long way in the treatment of major and minor ailments, protecting people from being poisoned by substances that may have cured them and also serving as food source.

Abstract Plants have been the source of food and medicine since time immemorial. Tribal people have been using several plants and their parts as source of alternative food that is conventionally not consumed by urban population. However recently, due to increasing population and reducing agriculture land, such alternative foods are gaining attention. Such alternative foods often also have medicinal value and are consumed by tribals for ameliorating certain disorders. Due to rising costs of modern medicine and associated side effects, general public perception is positive for alternative medicines and traditional therapies. Yams are an example of such alternative medicinal foods and are the focus of this chapter. Here we describe the ethnobotanical and nutraceutical potential of yams. We have discussed, in detail, some of the species that are consumed in various regions of India. During the compilation of this data, it was noticed that detailed molecular information is not available for most species, while for some species almost no molecular data exists. Further, many species have not been properly evaluated through modern natural product chemistry and pharmacological screening methods to validate the claims made in ethnobotanical surveys. These and other lacunas in knowledge pertaining to yams have also been pointed out towards the end of the chapter.

Abstract Crocus sativus L. commonly called as saffron is a Persian plant belonging to the Iridaceae family and is cultivated for more than 4000 years. It grows exclusively in India, the Balkans and the eastern Mediterranean region. Saffron is traditionally used for, as a food supplement and its pharmacological properties such as antihypertensive, anticonvulsant, anxiolytic aphrodisiac, antioxidant, antidepressant etc. It comprises of the dried stigma which comprises of 150 different types of metabolites, of which some are responsible for the color, flavor and aroma of the Saffron. Saffron is a plant with great significance as an adaptogen and seems to be promising as a nutraceutical in barring several diseases. The current chapter explores the Ethnobiology, historical background, chemical constituents, ethnopharmacological properties, uses and toxicity of Saffron.

Abstract Wild medicinal plants have been major source of therapeutic agents for alleviation or cure of human diseases since time immemorial. These are extensively utilized throughout the world in two distinct areas of health management i.e., modern medicine and or folk medicine. Some of the important medicinal plants grown and cultivated in India for medicine, phytochemicals, nutraceuticals, cosmetics and others are Abelmoschus moschatus, Aristolochia bracteata, Cassia alexandrina, Caralluma fimbriata, Gymnema sylvestre, Withania somnifera and other species. They have become important sectors of trade and commerce. However, in India, about 90% collection of medicinal plants is form wild source and since 70% of collections involve destructive harvesting, many plants have become endangered or vulnerable or threatened. The increasing demands of the pharmaceutical industry have created problem of supply and one of the major difficulties being experienced by the industry is that of obtaining sufficient quantities of medicinal plants for the manufacture of genuine medicine.

Abstract Mentheae, one of the largest tribes of subfamily Nepetoideae of family Lamiaceae is represented by five genera (Mentha, Nepeta, Origanum, Salvia and Thymus) in Jammu and Udhampur districts (Jammu division). Frequent surveys made of these districts to generate ethnobotanical data revealed the existence of Mentha arvensis L., M. longifolia (L.) L., M. piperita L., M. spicata L., Nepeta cataria L., Origanum vulgare L., Salvia splendens Sellow ex Schult and Thymus serpyllum L. While the enlisted Mentha species are represented more or less equally in the two districts, N. cataria, O. vulgare, S. splendens and T. serpyllum are mainly adapted to temperate regions of Udhampur. The frequent interactions with the locals indicated that except M. spicata whose leaves are used for seasoning dishes or preparing refreshing drinks and those of O. vulgare which find utility in making herbal tea, others are largely used for therapeutic purposes. Amongst these species, maximum use value was noted for M. longifolia (0.81) followed by that for M. arvensis (0.69). So far as agreement among the informants regarding the usage of a species for curing a particular disease is concerned, it came out to be maximum for both M. longifolia and M. arvensis for treatment of respiratory (Fic=0.93) and gastrointestinal problems (Fic=0.93). In our study, most of the informants have predisposition towards using M. longifolia for treating respiratory disorders particularly cough and cold. For this species, fidelity level was found to be maximum equal to 33.33%. This indicates that M. longifolia carries great potential for using in new herbal formulations. Finding of lesser use value for O. vulgare (0.21) and T. serpyllum (0.30), reportedly having many medicinal important components, is a matter of concern. The probable reasons underlying quite less usage of these taxa have also been discussed in this communication along with the future prospects of cultivating these.

Abstract Medicinal plants growing around us are the biggest gift to mankind from the nature. They grow abundantly and over centuries, humans have learned how to utilise plants for the treatment of illness. The great Himalayan belt is home to many endemic medicinal plant species. These plants are the rich source of traditional medicines and form a basis for livelihood of rural and indigenous populations. The present study is aimed to investigate the medicinal wealth of Bani valley that lies in Kathua district, (J&K) which is a part of Western Himalaya. Due to varying climatic conditions, terrains and forest types, the valley is home to various endangered and endemic medicinal plant species. A total 231 plant species belonging to 69 families ranging from angiosperms, gymnosperms and cryptogams (lycophytes and ferns) were documented by frequent field surveys and reviewed by published literatures and floras. Out of 231 plant species, herb species were 142, shrub species were 43 and tree species were 46. Asteraceae was recorded as dominant family followed by Fabaceae, Lamiaceae, Rosaceae, Polygonaceae, Ranunculaceae, Poaceae, Solanaceae, Acanthaceae and Urticaceae. Ethnobotanical data used for various ailments and diseases were obtained from local tribes.

Abstract Genus Chlorophytum is represented by approximately 300 species of rhizomatous plants, distributed predominantly in tropical and sub tropical forests of the world. Most of these are medicinally important. Chlorophytum borivilianum Santapau & R.R. Fern among these is highly valued because of high saponin content mainly concentrated in its tuberous roots. These steroidal saponins are important bioactive components responsible for aphrodisiac attributes of this species in addition to several other benefits. Present communication reviews the data available on medicinal properties and phytochemical constitution of the species.

Abstract Mythology is a unique subject of religious or cultural traditions. Plants play a vital role in the practice of these traditions. The use of plants may be an approach towards their conservation by demonstrating their magico-religious importance or their efficiency in keeping away some infectious microbes. Reason may be any, but all such herbs needs scientific interventions with respect to their usage. In this manuscript 69 such plant species are enumerated which are used for magico-religious purposes. Maximum species were recorded from dicots and seeds have shown maximum percentage among the plant parts to be used for the purpose. The knowledge about the magico-religious usage among the inhabitants is communicated through oral, literature or practice. The quantitative indices like Cultural Significance Index and Factor Informant Consensus have been calculated for the collected data from 92 informants in the region. The calculated ethnobotanical quantitative indices indicate Capsicum annuum and Santalum album are the culturally more significant plants and there is a strong homogeneity in the practices among the people of different districts.

Abstract India with plethora of flora and fauna is a rich repository of cultural and ethnic diversity. Bestowed with varied biogeographically distributed ecosystems and biodiversity hotspots, the country has always been the torch bearer as far as ethnobotanical knowledge is concerned. Jammu and Kashmir in the North-Western part of India has a rich biological and cultural diversity. Owing to the distinct geographical location and varied climatic conditions, district Poonch represents a rich repository of biodiversity including the wealth of medicinal plants. This study aimed at documenting and examining the use of plants in various medicinal herbal preparations. A total of 223 plant species belonging to 77 families and 173 genera were documented to be used as ethnomedicine by people residing in the study area. The portion of plant parts used were leaves (28.14%), followed by root (16.33%), fruit (11.55%), whole plant (10.3%), stem (09.79%), flower (7.53%), seed (5.27% each), rhizome (4.77%), tuber (3.76%), bulb (1%) and bark and latex (0.75% each). These parts are utilized as herbal remedies for curing 109 human ailments such as abscess, acidity, asthma, back pain, body pain, boils, cancer, cholera, cold, cough, dandruff, erectile dysfunction, eye pain, fever, gastroenteritis, haemorrhoid, high blood pressure, menstrual disorders, sexual disorders, stomach pain, diabetes, diarrhoea, dysentery and weakness. The dominant disease was fever (52), followed by abdominal pain (30), cough (29), headache (22), constipation (20), diabetes (18), wounds (17), weakness (16) and others. There is need for proper documentation and an attempt has been made to highlight high value medicinal plants so that proper strategies could be made for their conservation.

Abstract Pomegranate, Punica granatum L., is an ancient fruit tree native to the Middle East. All plant parts are rich source of the various secondary metabolites that accounts for its antioxidant and health-promoting activity. A strong genetic control on anthocyanin production is responsible for variability in the color of peel and arils of pomegranate. Characterization, cloning and expression of the genes related with anthocyanin and tannin production provides routes for engineering of these complex pathways. Recent studies on pomegranate genome sequencing have elucidated several biochemical pathways and candidate genes that could assist to increase production of potent bioactive compounds in near future. This will further facilitate our understanding to some exclusive biological processes that plays a significant role in pomegranate breeding.

Abstract Jasrota Wildlife Sanctuary (JWS) in Jammu and Kashmir (J&K) Union Territory is floristically less explored. Between 2018 and 2019, field surveys and exploration tours were undertaken to obtain information from local people residing around JWS through open interviews, semi-structured questionnaires and group discussion. Total 113 informants were contacted and data collected by means of ‘snowball method’. A total of 138 species of 60 medicinal plant families were documented subjected to preliminary investigation, which includes 47.10% herbs, 28.26% trees, 19.57% shrubs, 4.35% lianas, and 0.72% parasites. Most dominant families were Fabaceae (11 gen. and 12 spp.), Lamiaceae (6 gen. and 8 spp.), Asteraceae (8 gen. and 8 spp.), Moraceae (2 gen. and 6 spp.), Caesalpinaceae (4 gen. and 6 spp.), Rosaceae (5 gen. and 5 spp.), Euphorbiaceae (4 gen. and 5 spp.), Solanaceae (4 gen. and 4 spp.) and Malvaceae (4 gen. and 4 spp.). Some of the common high valued medicinal plants were Ajuga integrifolia, Aloe barbadensis, Asparagus adscendens, Boerhavia diffusa, Cassia fistula, Lantana camara, Murraya koenigii, Ocimum tenuiflorum, Tinospora cordifolia, Zingiber officinale and several other plants. Traditionally lesser used plants were Abrus precatorius, Acacia catechu, Commelinabenghalensis Cyperus rotundus, Silene vulgaris, Robinia pseudoacacia, Urtica dioica and Ziziphus mauritiana. These medicinal plants are used in treatment of obesity, anti-helminthic, liver infection, diabetes, intestinal infections, rheumatism, tumours, stomachache, insomnia, nerve troubles, skin infection, aphrodisiac, memory related disorders, dermatological problems and asthma. Species with high frequency index should be analyzed for pharmacological research and for discovering of new medicines. It has been observed that lots of medicinal plants grows in this protected area and this sanctuary need proper conservation and management planning.

Abstract Genus Artemisia L. (Asteraceae) has a long history of use in herbal medicine, owing to the presence of rich bioactive phytochemical diversity of it constituent species. Himalaya is hub of several species and species under this genus have been traditionally used in different ways for curing ailments by inhabitants of the areas where their populations sprawl. Few species such as A. annua and A. maritima are cultivated for their use in medicine. In addition, the species of the genus have found wide usage in matters connected to digestive system especially for treatment of worms and for preparation of herbal teas. Artemisnin, a potent source of anti-malarial drug extracted from some species, is most valuable bioactive phytochemical of this genus. Other important chemical constituents include santonin and scoparine. Reported studies suggest that the bioactive constituents present in this genus shows several biological activities such as antimicrobial, anti-inflammatory, anticancerous and other allied ones activities. Expansion of range and acclimatization in new habitats is exemplary in this genus. Present work reports the ways of range expansion, economic importance, conservation strategies and future prospects of this genus.

Abstract Toxic plants are a grave threat to existence and bodily functions of humans and animals resulting in death or sickness through accident, unawareness or bad intention resulting in huge economic loss. They have always been part of our daily life and some of them are so prevalent that we do not even doubt their poisonous nature. The study aimed at systematically documenting the precious traditional knowledge regarding the ethnotoxic plants of district Udhampur. Ethnotoxic data was collected by interviewing 125 infomants between the age group 24-95 years. A total of 89 plant species belonging to 69 genera and 43 families were observed to be toxic to either humans or animals or both. Majority of the taxa were growing in wild. Leaves were observed to be the most toxic plant parts. Frequently encountered toxic plant families include Fabaceae, Solanaceae, Asteraceae, Euphorbiaceae, Apocynaceae and Ranunculaceae. The route /mode of entry of toxic chemicals was mainly observed to be ingestion. A total of 62 ailments/ conditions/diseases were reported to be caused in humans or animals or both by the ingestion, contact or inhalation of toxic plants in the present study. These include nausea, vomiting, headache, diarrhoea, hematochezia, abdominal spasms, anorexia, dysuria, deep yellow or no urine, bloat, etc. The present study may serve as a base line data for further research and will go a long way in safeguarding people from being poisoned by stuff that may have healed them.

Abstract Herbal healthcare forms the most favored system for curing various ailments of the people residing in remote areas of Himalayan region. Gujjar and Bakerwal tribes inhabit the hilly areas of Pir Panjal region of J&K along with their livestock and rely on the surrounding bio-wealth for their healthcare needs. But, proper documentation of traditional knowledge about the medicinal plants has been poorly attempted in this part of J&K. In order to develop a data base of plants being used by Gujjar and Bakerwal tribes of district Poonch, present attempt has been made. The present compilation recorded one hundred forty five plant species belonging to 133 genera and 76 families which are used by the tribal people to cure various ailments like rheumatism, diarrhea, dysentery, skin and gastric problems, wound healing etc. These medicinal plants comprise of 25 trees, 27 shrubs, 82 herbs and 11 climbers. Of the total, 44 species are native to Himalayan region and 101 are non native. Keywords: Indigenous knowledge, Medicinal plants, Healthcare, Gujjar, Bakerwal

Abstract Malaria is a widespread disease in the developing world, known to mankind since primeval times. It exists over hundreds countries of the world. Malaria is caused by the Plasmodium parasite and cause disease in over 30 crores people annually and kills approximately 10 lakhs people worldwide. Plasmodium protozoan species which causes malaria can be differentiated into four species viz. P. malariae, P. falciparum, P. vivax, and P. ovale. Among all these four species P. falciparum parasite has got resistance to all common antimalarial drugs available in the market; therefore it is a devastating strain of Plasmodium causing of serious disease and death. The rising resistance of existing remedy based on quinoline is a key provider to the re-emergence of malaria as a main public health difficulty and its widen to fresh locations and populations. Therefore, In this compilation, an effort is made to compile clinical features of malaria, life cycle of Plasmodium sp., different classes of antimalarial drugs and their mechanism of actions and recent advances in target based discovery and recent development in artemisinin research especially different kinds of artemisinin derivatives and new structural classes of antimalarial agents. We have also reviewed new leads discovered as antimalarial from natural products where we have possible to see new lead in near future.