Introduction
Hematology is the study of blood and its constituents. Blood is a specialized fluid connective tissue, which consists of plasma (55-70%) and the formed elements (30-45%) that flow all over the body in the vessels of the cardiovascular system. Plasma comprises water (90-92%), proteins (6-7%), enzymes, hormones, lipids, and organic & inorganic constituents. The three major classes of plasma proteins include albumin, globulin, and fibrinogen. The organic elements include non-protein nitrogen (NPN) compounds (like urea, uric acid, creatine, creatinine, amino acids, glutathione, and xanthine), glucose, neutral fats, phospholipids, cholesterol and others. The inorganic constituents include calcium, phosphorus, magnesium, potassium, sodium, chlorine, sulfur, iodine, iron, copper, cobalt, manganese, zinc, selenium, and molybdenum; they contribute about 1 percent of the plasma.
Blood performs various functions by its constituents. The constituents of the blood are highly dynamic, and they inter shift from their reference values very quickly in any adverse condition. This is why; studies of blood cells and complete blood count (CBC) are important for accessing general health, diagnosing various diseases, and providing prognostic information when coupled with a thorough physical examination. The blood examination is performed routinely to diagnose hematological diseases, including certain hereditary diseases of the blood, and to determine the body’s ability to respond to a hematological insult. The key parameters evaluated in the hemogram are ESR, PCV, Hb, TEC, MCV, MCHC, TLC, and DLC.