eChapters

I. FILL UPS

1. The area of science that studies the relationship between pathogens and seeds is _____.
2. The diseases that are caused by fungal pathogens in residues and on the soil surface are defined as _____.
3. The establishment of a pathogens in any part of the seed is referred as _____.

Jamun, Syzygium cumini Skeels, belongs to the family Myrtaceae and genus Eugenia which comprises about 1000 species of evergreen trees and shrubs. Some of the old-world Eugenia spp., are now placed in the genus Syzygium. The genus Syzygium is a multipurpose genus with many important species.

The original home of jamun is considered to be India (Singh, 1969), while it is also found in Thailand, Philippines, Madagascar and other African countries. In India, jamun is mainly grown in eastern Himalaya, Kumaon, Gangatic plains, Tamil Nadu, Assam and Andamans. It grows well in marshy land and also in neglected wastelands.

Cultivars/Varieties: There are no improved variety of jamun for commercial cultivation. The most common type grown in north India is known as Raja jamun. This is a large-fruited type having oblong fruits of deep purple colour. A type having large- sized fruits is known as Paras in Gujarat. Another type found in Varanasi has no seed. A selection with desirable traits has been located by the CSA University of Agriculture and Technology at Faizabad. It has been named as Narendra Jamun 6.

Uses

Jamun fruits are deep purple to violet in colour and are, therefore, very attractive. The anthocyanin pigment is responsible for the colour. The products made from jamun are jellies, jams squash, beverage, wine vinegar and pickle. In Goa and the Philippines, jambolans are an important source of wine, somewhat like Port, and the distilled liquors, brandy and “jambava” have also been made from the fermented fruit. Jambolan vinegar, extensively made throughout India, is an attractive, clear purple, with a pleasant aroma and mild flavor.

Semiochemicals are chemical substances that mediate communication between organisms.

Classified into pheromones (intra specific semiochemicals) and allelochemicals (inter specific semiochemicals).

Lymphnodes are found in every part of the body except

a) Digestive system b) Respiratory system

c) Cardiovascular system d) Central nervous system

Lentil is one of the oldest nutritious rabi pulse crop. The whole or splitted seeds are used in preparing dal and delicious namkin commonly called dalmoth. The splitted seeds are also used in making soup and porridge. Green pods are used as vegetables. The leaves and stalks are used as cattle feed.

Lozenges are solid preparations that contain one or more medicaments, usually in a flavored, sweetened base, that are intended to dissolve or disintegrate slowly in the mouth. They can be prepared by molding (gelatin and/or fused sucrose and sorbitol base) or by compression of sugar-based tablets. Molded lozenges are sometimes referred to as pastilles, whereas compressed lozenges may be referred to as troches. They are used for patients who cannot swallow solid oral dosage forms well as for medications designed to be released slowly to yield a constant level of drug in the oral cavity or to bathe the throat tissues in a solution of the drug. Lozenges historically have been used for the relief of minor sore throat pain and irritation and have been used extensively to deliver topical anaesthetics and antibacterial.

Advantages

1. It is easy to administer to both paediatric and geriatric patients.
2. It has a pleasant taste and will extend the time a quantity of drug remains in the oral cavity to elicit local activity.

9.1. Principles of food preservation by heat

• Pasteurization temperature at below 100°C

• Heating at about 100°C

• Sterilization temperature at above 100°C

9.1.1. Pasteurization

• Heat treatment kills part, but not all microorganisms present and temperature below 100°C.

• Heating by means of steam, hot water, dry heat or electric current and cooled after heat treatment.

• Surviving microorganisms are inhibited by low temperature or some other preservative method, if spoilage prevented.

• Preservative methods used to supplement pasteurization include

? Refrigeration, e.g. milk

? Keeping out microorganisms usually by packaging the product in a sealed container

Calcification

• Calcification is abnormal deposition of calcium salts in tissue other than bone.

• Calcium is normally present in blood and deposited in bones.

• Calcium if deposited in an abnormal tissue with normal or abnormal blood calcium level is considered as pathological condition.

Pathological calcifications are

1. Metatstatic calcification

2. Dystrophic calcification

Pharmacovigilance
Definition
Pharmacovigilance (PV) is defined as the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The term combines the Greek word «pharmakon,» meaning drug, and the Latin «vigilare,» meaning to keep watch. Thus, pharmacovigilance focuses on monitoring the safety of medications after they have been authorized for use to ensure that their benefits outweigh any potential risks.
Aim of Pharmacovigilance
The primary aim of pharmacovigilance is to enhance patient safety and ensure the safe use of medicines by:
• Identifying Adverse Drug Reactions (ADRs): Collecting data on adverse effects associated with medications to understand their frequency, severity, and risk factors.
• Assessing Risks: Evaluating the risk-benefit profile of drugs in real-world settings beyond clinical trials.
• Preventing Harm: Implementing strategies to minimize risks associated with drug use, thereby protecting public health. • Improving Drug Safety: Continuously monitoring and analyzing data to improve the safety profiles of existing medications and inform regulatory actions.
Scope of Pharmacovigilance
The scope of pharmacovigilance encompasses a wide range of activities and responsibilities:
1. Data Collection
• Gathering information on ADRs from various sources, including healthcare professionals, patients, clinical trials, and post-marketing studies.
• Utilizing spontaneous reporting systems where healthcare providers report suspected ADRs.

ABSTRACT

This paper presents few measures to be taken up by academic institutions, professional societies, industrial bodies and governmental agencies for the propagation of information of IPR in terms of encouragement of publication of books on IPR, establishment of IPR cells in academic and professional institutions and making IPR education as part of curriculum in Universities and institutions of higher learning.

Materials Required

Sample, Liebig condenser, digestion flasks (700-750 ml cap), conical flasks, filtering cloth (thick linen cloth for clear filtration) reagents, muffle furnace, crucibles.

Reagents

    1.    0.255 N Sulphuric acid solution : Dilute 2.5 g (1.36 ml) of concentrated H₂SO₄ to 200 ml. Ensure correct concentration by titration.
    2.    0.313 N Sodium hydroxide solution: 2.504 g NaOH / 200 ml water nearly free from sodium carbonate. Ensure correct concentration by titration.
    3.    Asbestos Chips: gooch grade, medium fibre, acid wash and ignited
    4.    10% Potassium sulphate (K₂SO₄) solution: Dissolve 10 g of Potassium Sulphate (AR) in water and make up to 100 ml.

Crude protein of feedscontain true proteinandnon-proteinnitrogen. Trueprotein is madeupaminoacids andforthemaximumefficiency, feed musthave essential amino acids in correct proportion, correct balance as well as non essential amino acids should also be in sufficient amounts. About digestion in simple stomached animals, the true protein is degraded to oligo peptides (less than ten peptides) in the stomach, subsequently to mono peptide and amino acids in the small intestine. Thereafter amino acids are assimilated in the small intestine. But in ruminants, the situation is complex in the sense that feed proteins get digested in the rumen but even amino acids are also broken down by microbes and thereafter, amino and carboxylic groups are released. Secondly, synthesis of new amino acids or proteins takes place for the formation of their own microbial body coat. Because of these reasons, the approach for protein evaluationor expressionisdifferent inruminant andnon-ruminant animal.Further, non-protein nitrogen portion of feed can not be utilized effectively by non – ruminants like swine and poultry. These animals are usually fed with oil cakes, cereals and cereal by-products, which are poor in non-protein nitrogen compounds, however, young succulent fodders, clover etc. are rich in such compounds.

I. FILL UPS

1. _____ refers to the health status of a seed.
2. A group of fungi that infects developing seeds on the plant in the field, but before it is threshed is called as _____.
3. _____ fungi invade seeds at (or) after harvest.
4. _____ method is used particularly for smut and bunt fungi in gramineous host.
5. _____ method is used for detection of karnal bunt of wheat.

Introduction

DNA denaturation, also called DNA melting, is the process by which double-stranded deoxyribonucleic acid unwinds and separates into single-stranded strands during the breaking of hydrogen bonding between the bases. Both terms are used to refer to the process as it occurs when a mixture is heated, although “denaturation” can also refer to the separation of DNA strands induced by chemicals like urea. For multiple copies of DNA molecules, the melting temperature (T_m) is defined as the temperature at which half of the DNA strands are in the double-helical state and half are in the “random-coil” states. The melting temperature depends on both the length of the molecule, and the specific nucleotide sequence composition of that molecule.

Applications of DNA Denaturation

The process of DNA denaturation can be used to analyze some aspects of DNA. Because cytosine / guanine base-pairing is generally stronger than adenosine / thymine base-pairing, the amount of cytosine and guanine in a genome (called the “GC content”) can be estimated by measuring the temperature at which the genomic DNA melts. Elevated temperatures are associated with high GC content. GC ratios within a genome are found to be markedly variable. These variations in GC ratio within a genome of higher organisms results in a mosaic like formation with islet regions called isochores. This results in the variations in staining intensity in the chromosomes. The isochores include in them essential protein coding genes, termed housekeeping genes and thus determination of ratio of these specific regions contributes in mapping these essential genesbacterial systematics has recommended use of GC ratios in higher level hierarchical classification. For example, the Actinobacteria are characterised as “high GC-content bacteria”. In Streptomyces coelicolor A3(2), GC content is 72%. The GC-content of Yeast (Saccharomyces cerevisiae) is 38%, and that of another common model organism Thale Cress is 36%. Because of the nature of the genetic code, it is virtually impossible for an organism to have a genome with a GC-content approaching either 0% or 100%. A species with an extremely low GC-content is Plasmodium falciparum (GC% = ~20%), and it is usually common to refer to such examples as being AT-rich instead of GC-poor.

The term dandruff includes several different conditions of the scalp. There is scaling in which the entire scalp may be covered with loose dry scales. When the hair is combed or brushed, or when the scalp is scratched, these scales fall like snow on the shoulders. Often there is itching, as well, and the scalp may be red from scratching.

What is at first thought to be dandruff may later prove to be some other conditions, such as. seborrhoeic dermatitis, or worse still psoriasis and even neurodermatitis.

Neurodermatitis : It is a chronic type of itching and inflammation of the skin. The itching area may be in some localized spot or it may extend over large areas of the body. The condition may even develop in infants. It may disappear after the age of two and return in the early teens of later. The condition is more often seen in those who suffer from fever, hives and asthma. True cause is not known for most of the people are allergic to many things. Many of them are tense and restless and are troubled with a dry skin. They are hypersensitive and are often given to itching, especially in the bend of elbow or behind the knee. The constant scratching leaves deep scratch marks and causes thickening and furrowing of the skin.

1 Condition characterised by bran - like scales on skin surfaces is called

a) Pustule b) Parakeratosis

c) Erythema d) Pityriasis

Tabletting is the area where sugar confectionery and pharmaceutical manufacture come closest, as the machines are similar the process can also be similar. Confectioners normally try to make tablets as hard as possible whereas pharmaceutical tablets are normally made to be fairly soft.

Tablets are made by compressing a powder in a die. Under pressure the powder fuses and is ejected as a tablet. The problem of tabletting is to produce a powder that will flow freely when poured into the die but bonds satisfactorily when compressed. Some materials are available in a directly compressible form. One example is sorbitol, which goes some way to explain the popularity of pressed sorbitol tablets with manufacturers. If directly compressible materials are not being used then the material must be granulated before being tabletted.

Granulation

Tabletting materials can be prepared by a number of different methods as outlined below:

Introduction

It is a subtropical, evergreen fruit tree. Its trees can be short-spreading and fairly bushy or grow erect to a height of 20 m. Tree demand for this fruit has been increasing over the past few years in many countries. It has become an important fruit in international trade. Mexico, Colombia, Dominic Rep, Peru, Indonesia, South America and South Africa are the major producers of avocado. In India, it is grown as a backyard tree and is found in small pockets on the hill slopes of Tamil Nadu, Kerala, Karnataka and Maharashtra. Composition and uses: One of the most nutritious fruits, rich in fat, protein, and minerals and low in carbohydrates, is the avocado. It can be safely eaten by diabetics. Fruit is used as a dessert in salads, ice creams, and milk shakes.

Immature fruits may have a bitter flavour that may be reduced on ripening; the peel of avocado has 3 antifungal compounds. Its energy value is twice as much as banana fruit. Rich in fat 26.4% and low sugar 1% content and rich in K, Fe, Vitamin B, As the sugar content is low, it can be recommended as a high-energy food for diabetics. Fruit is a rich source of oil, ranging from 5–20% used for the cosmetics industry.

Photosensitization is activation of photodynamic chemicals on the skin by long wave length UV or occasionally by visible light

• Necrosis and edema are produced in the exposed areas of skin of animals.

• The cellular damage by photosensitization is due to release of reactive oxygen species leading to mast cell degranulation and production of chemical mediators of inflammation.

Factors Necessary for Photosensitization in Animals

• Oxygen

• Sunlight

• Photodynamic chemicals

• Skin devoid of hair or wool and lacking pigments

Veterinary practice has gone through different phases with different components
• Phase I - Patient and Veterinarian: objective was only to treat illness of  the patient by veterinarian.
• Phase II – Patient - Veterinarian – Owner: Veterinarian was to take  recognition of owner and his/her needs.
• Phase III - Patient - Veterinarian – Owner – Law: Additional  responsibility on veterinarians to work as per the law (e.g. Registration  at VCI, Veterinary jurisprudence, Giving evidence at court of law, Health  certificates,    Death    certificate,    Cruelty    to    animals,    export   and    import    law,     euthanasia rules, etc.)
• Phase IV - Patient - Veterinarian – Owner – Law – Environment: Further  added responsibility to protect environment.  E.g. Biomedical waste  management.