eChapters

Cadmium, a roxic heavy metal, poses risk in a significant manner especially to human health and the environment. It's wide spread industrial use and presence in various products make exposure a concern particularly for both environmental and occupational settings. Understanding the source, toxico dynamics, toxico kinetics, clinical manifestations, diagnosis as well as treatment of cadmium poisoning is critical in mitigating it's adverse effects especially on human health. Cadmium gains an entry into the environment through natural processes namely volcanic activity as well as weathering of rocks. Whatever it may be, human activities along with mining, smelting, refining of metals and manufacturing of batteries, plastics as well as pigments, are major contributors to cadmium release especially into the environment. Additionally, cadmium is seen in tobacco smoke, resulting in exposure among smokers as well as passive smokers. Once released into the environment, cadmium gains entry into the human body through many routes such as inhalation, ingestion and dermal contact An inhalation of cadmium containing dust or fumes is a prominent route of exposure in an occupational settings especially in industries namely mining, smelting as well as welding. The consumption of contaminated water and food is another general route of exposure especially for the general population. After consumption, cadmium in essential manner accumulates especially in the kidneys as well as liver with a half life of approximately 10 - 30 years in the organs. It also accumulates particularly in bones, where it consists of half life of several decades.

Arsenic is a naturally occurring element that can be observed in various forms in the environment, including soil, water, and air. While arsenic has some industrial applications, it is also notorious for its toxicity to humans. Exposure to arsenic can happen through ingestion, inhalation, or skin contact, with ingestion being the most common route of exposure in cases of poisoning. Here, authors provide information regarding the source of arsenic intoxication, its toxicology kinetics and dynamics, clinical signs and symptoms, lesions, diagnosis, and treatment.

Introduction

In this article, authors provide information regarding source of intoxication also.

Source of Intoxication

Arsenic poisoning can lead to various sources, including:

Contaminated Water

Arsenic contamination of drinking water is a significant concern in many parts of the world, specifically in regions where natural geological formations consists of high levels of arsenic.

Aluminium is a ubiquitous metal and seen in an environment. Source of aluminium happens through dietary souce, food addivitives, packing materials, medications, environmental exposure as well as occupational exposure. Toxico kinetics is related to the interaction of aluminium with biological systems and toxicity also. Toxico dynamics of aluminium is related to the the oxidatve stress, neuro toxicity and bone toxicity. Diagnosis is based on MRI scan and measurement of serum as well as urine. Treatment is dependent on chelation therapy as well as avoidance of exposure. Finally it is concluded that aluminium toxicity leads to health risks in a significant manner along with potential adverse effects on neurological, gastro, intestinal, renal as well as skeletal systems.

Introduction

Aluminium is a ubiquitous metal observed naturally in the environment. It is widely used in various industrial and consumer products including cookware antacids, vaccines, and food additives. While aluminium is normally considered safe in low concentrations and exposure to high levels can lead to toxicity causing a range of adverse effects on human health. In this comprehensive article, authors will provide information regarding its toxicokinetics and toxicodynamics, clinical signs and symptoms, associated lesions, diagnosis and treatment strategies.

Understanding the Toxicity of Macrolide Endectocides

Introduction

Macrolide endectocides are a class of compounds widely used in veterinary medicine to combat internal and external parasites in livestock and companion animals. While these medications have proven to be effective in controlling parasites, there are concerns regarding their potential toxicity and adverse effects on animals and the environment.

Whar are Macrolide Endectocides

Macrolide endectocides belong to a group of compounds derived from naturally occurring macrolide antibiotics, such as avermectins and milbemycins. These compounds have broad-spectrum activity against various parasites, including nematodes, arthropods, and ectoparasites like ticks and mites. Some commonly used macrolide endectocides include ivermectin, doramectin, moxidectin, and eprinomectin.

Toxicity Concerns

While macrolide endectocides are generally safe and effective when used according to label instructions, there are instances where toxicity can occur. Factors influencing toxicity include:

Introduction

Phenothiazines are a class of drugs primarily used to treat psychiatric disorders such as schizophrenia, bipolar disorder, and severe anxiety. While they can be effective in managing these conditions, they also come with potential risks and toxic effects when not used properly. Understanding the toxicity of phenothiazines is essential for healthcare providers and patients alike to ensure safe usage and minimize adverse effects.

Mechanism of Action

Phenothiazines exert their therapeutic effects by blocking dopamine receptors in the brain, thereby altering neurotransmitter activity and reducing symptoms of psychosis. Additionally, they also block other receptors such as histamine and alpha-adrenergic receptors, contributing to their sedative and antiemetic properties.

Types of Phenothiazines

There arevarious phenothiazine derivatives available, including chlorpro mazine, fluphenazine, thioridazine, and promethazine, among others. Each may have slightly different pharmacological properties and side effect profiles, but they share common characteristics regarding toxicity.

Toxic Effects

Extra Pyramidal Symptoms (EPS)

One of the most well-known toxic effects of phenothiazines is the development of extrapyramidal symptoms, which include akathisia, parkinsonism, and tardive dyskinesia. These symptoms can range from mild discomfort to severe motor disturbances and can be particularly problematic with long-term use.

Introduction

Azoles, a class of organic compounds containing a five-membered nitrogen containing ring, have garnered significant attention in various fields, including agriculture, medicine, and industry. These compounds are renowned for their diverse applications, particularly as anti fungal agents in both human and veterinary medicine, as well as in agriculture for crop protection. Whatever it may be, alongside their efficacy, concerns have arisen regarding their potential toxicity and environmental impact.

The Role of Azoles

Azoles play a crucial role in combating fungal infections in humans and animals. They inhibit the synthesis of ergosterol, a vital component of fungal cell membranes, thereby disrupting fungal growth and proliferation. Additionally, azoles are used in agriculture to protect crops from fungal diseases, contributing to higher yields and improved food security.

Toxicological Concerns

While azoles have proven effective in controlling fungal infections, their use raises concerns due to potential adverse effects on human health and the environment. The toxicity of azoles stems from several factors, including their mode of action, chemical properties, and metabolic pathways.

There is no terminal of any kind of research, rather they presence a static snap of the gamut of ecological dynamics and functions.

The following scopes for future research

• To construct modelling on resilience, beyond agriculture like livestock f ishery, forestry.

• To create new Algorithm of prediction in ecological behaviour and dynamics

• Gender and economic factors in resilience study and analysis

• Ecological resilience in different agro climatic zones covering coastal ecosystem, Himalayan ecosystem red lateritic ecosystem etc

• Policy research in ensuring and intriguing ecological resilience as well as social resilience on the common platform of production behaviour

• Importance of ecological resilience in the perspective of climate change and global warming

7.1 Summary

Never ever in the annals of human civilization, the importance of ecological resilience has become so important and imperative as we are perceiving now. Both the need and greed of food economics have driven the resource bases of our ecosystem, to a dilapidated and fragile status. By 2050 the world’s population will touch close to 9.5 billion and we have to scale up our food production 60% more then what it is right now. In India by 2040, we have to cross 450 million tons of our targeted food production to keep rhythm with population growth. By 2035 we are going to cross the population of China. Understanding the cascade of risks for climate change, as well as the vulnerabilities to these risks, is key to frame ways to adapt. Reducing vulnerabilities is key to reducing the net impacts on food security and nutrition and also to reducing long-term effects. Increasing resilience of food security in the face of climate change calls for multiple interventions, from social protection to agricultural practices and risk management..

When population pressure is soaring up, the need to produce more food from less and less available land and water, the issues of ecological resilience are coming up more swashbuckling and humongous. The aftermath of green revolution has contributed to achievement in food security on one hand, the other hand water has been contaminated and depleted, soil has been eroded with a sharp decline of organic carbon. We are losing 15 tons of topsoil per hectare per year and inviting a disruptive agro-ecosystem, the syndrome of which are quite vivid and prominent.

6.1. Data Interpretation and Visualization of West Bengal

Any kind of production management system or decision-making process is being organised in social ecology. No variable cannot behave discrete or free without having any kind of influence as well as impact from the vary operating ecosystem. That is how it is imperative to know and visualize the basic features in terms of its distributive characters. The distribution of features in variables through this networking and interactions ultimately contribute to a holistic visualization of social ecologization under study.

Table 6.1.1 represents the distribution of variables in terms of range i.e. maximum and minimum values, mean, standard deviation and coefficient of variation for Terai Zone, Old Alluvial Zone and New Alluvial Zone of West Bengal.

The average age (x1) of the respondent stands at 49.02. It denotes that so far as responsibility of agriculture and age base livelihood runs at the population so far as the respondent under study is peaks are at the hands of farmers approaching or passing through old ages. On the contrary the absence of young population or withdrawal of young age farmers from agriculture have got a serious implecation near and far. The cv value runs at 25.78 per cent to indicate that the distribution of variable is highly consistant.

The average of functional education (x2) of the respondent stands at 8.20.The variable education charecterization the social ecology speaks that the most of the respondents are having mid level school education.So, this has got spil over effect on the function and operation of other variables i.e. precisely the perception variables.The cv value stands at 43.69 per cent that’s good enough to infer that the distribution of the variable is highly consistent.

5.1 Locale of Research

Based on the All-India assessment report regarding Climate Vulnerability Assessment for Adaptation Planning in India Using a Common Framework which identifies the most vulnerable states and districts in India with respect to current climate risk and the main drivers of vulnerability, the present study has been conducted in two relatively highly vulnerable states of India namely West Bengal (Vulnerability Indices:0.592) and Jharkhand (Vulnerability Indices: 0.674). It specifically comes under Agro-climatic zone III (Lower Gangetic plain region) and Agro-climatic zone VII (Eastern plateau and hilly region) respectively.

On the basis of Vulnerability Indices (Vis) different district of West Bengal classified into three categories i.e. relatively high vulnerability (0.59-0.69), moderate vulnerability (0.49 -0.59), and relatively low vulnerability (0.38- 0.49). Two districts, Malda (VIs:0.690) and Jalpaiguri (VIs:0.627) from highly vulnerable and three district Murshidabad (VIs:0.524), Dakshin Dinajpur (VIs:0.523) and Burdwan (VIs:0.497) from moderate vulnerable category were selected purposively for the present study. For satisfying the purposes three agroclimatic zones of the West Bengal, viz. Terai Zone (Jalpaigudi), Old Alluvial Zone (Murshidabad and Dakshin Dinajpur) and New Alluvial Zone (Burdwan) districts were taken into account for the assessment. Twenty respondents of two Villages from each Block i.e., Alipurduar-I of Jalpaigudi, Hilli and Gangarampur of Dakshin Dinajpur, Old Malda of Murshidabad and Barabani of East Burdwan were purposively picked for the research study.

In any social science research, it is hardly possible to conceptualize and perceive the data and interpret the data more accurately until and unless a clear understanding of the characteristics in the area and attitude or the behavior of people is at commend of the interpreter who intends to unveil an understanding of the implication and behavioral complexes of the individual who live in the area under reference and form a representative part of the larger community. The socio-demographic background of the local people in a rural setting has been critically administered in this section. A research setting is a surrounding in which input and elements of research are contextually imbibed, interactive and mutually contributive to the system performance. Research setting is immensely important in the sense because it is characterizing and influencing the interplays of different factors and components. Besides the investigators must also have the basic knowledge about the socio demographic background of the people so as to have an easy understanding of their knowledge, attitude and behavior.

Research setting refers to the detail information of an area where the study has been conducted. The study area, generally comprises of a particular geographical area viz. a state, district, block, or gram panchayat area selected according to the convenience of the investigator who possess adequate knowledge regarding the location, communication facility etc. of the locality so that he/she can easily approach each and every corner of the area for data collection. Here. in this study the data collection was done mostly over telephone based on the interview schedule due to Covid-19 pandemic situation.

3.1 Conceptual Framework

Aconceptual framework is an analytical tool that is used to get a comprehensive understanding of the study. It embodies the specific direction by which the research will have to be undertaken. It is generally constructed to provide the researcher the element ofattainable and researchable problems and ideas supported by methodology, design, prospective analysis and empirical conclusion. The conceptual framework is often called as the research paradigm.

The subject matter of the present research is Resilience and productivity of agriculture in different social-ecology: the farmers’ perception, status and interpretation. It is expected that the terminologies and concepts used to frame up the topic need to undergo brief explanation for the better understanding of its meaning.

Resilience: Resilience is about anticipating, planning and reducing disaster risk to effectively protect persons, communities and countries, their livelihoods, health, cultural heritage, socio-economic assets and ecosystems. The ideas of ‘bounce back’, ‘spring forward’ and ‘build back better’ are often used in the context of resilience.

Productivity: Productivity is commonly defined as a ratio between the output volume and the volume of inputs. It measures how efficiently production inputs, are being used in an economy to produce a given level of output.

Agriculture: The word agriculture derives from the Latin ager (field) and colo (cultivate) signifying, when combined, the Latin agricultura: field or land tillage. But the word has come to subsume a very wide spectrum of activities that are integral to agriculture and have their own descriptive terms, such as cultivation, domestication, horticulture, arboriculture, and vegeculture, as well as forms of livestock management such as mixed crop-livestock farming, pastoralism, and transhumance. The Oxford English Dictionary (1971) defines agriculture as “The science and art of cultivating the soil, including the allied pursuits of gathering in the crops and rearing livestock; tillage, husbandry, farming.”

This chapter is an extensive survey of all past studies relevant to the field of investigation which gives a knowledge of what others have found out in the related f ield of study. In any scientific investigation or research a comprehensive presentation of review of literature is a statutory requirement. Its main functions are to develop a better understanding of the problem to be investigated, delineate a new area of study and avoid unnecessary duplication, decide on the tools and techniques to be adopted including developing some new ones, also to relate the present study with the previous ones by finding out the areas of agreement and disagreement.

The review of literature of the present study is based on the major concepts related to the f ield of investigation. As direct references on all the item are not in abundance, certain specific references along with some indirect references have been incorporated in this chapter for the purpose of meaningful use.

Review of literature has been organized with a view to provide hard evidences as to clinically justify the reasons, logic, and contemplation leading to heuristically infer the different echelons of resilience issues.This is also catered to isolate the apparently less attempted genre of resilience study and analysis. Climate change, uncertainty, decline of soil organic carbon, fatigued genes on land, loss of biodiversity and fragile ecology of society have only been some of myriad of factors causing the loss of resilience, from ecology and from society as well.

1.1. Background

Once this beautiful planet conceived human civilization with the glory of motherhood, the birds kept on twittering in an ecstasy of joy and freedom; the ripples of pristine rivers, blue and giggling, offered shelter to silvery fishes and pink Amazon Lilies! But human greed has defeated its own needs. So, what had been a means to survive now has turned into tools to triumph, rather, a weapon to destroy her own creation. By this time, we have transformed fertile lands into a barren Arizona, deep forests into a nasty slums and blue rivers into a filthy stream, called Yamuna.

The advent of the Anthropocene, implies that an unprecedented era of human impact on the natural environment, is now so large that the Earth has entered a new geological epoch; it is leaving the Holocene, the environment within which human societies themselves have developed (Gornish and dos Santos, 2016; Reynolds, 2021). Climate change is a prominent sign of human- driven changes to the global environment. There is every reason to be alarmed about anthropogenic climate change, pollution, and biodiversity loss, all of which have been accelerating in recent decades and do pose “existential crisis” (Díaz et al., 2020; Abhilash et al., 2021). Sixth Assessment Report of Intergovernmental Panel on Climate Change (IPCC) released on February 28, 2022, paints a troubling picture as limiting global warming to 1.5oC (a global target in the Paris Climate Agreement) is not safe for all. If warming exceeds 1.5oC, even temporarily, much more severe, often irreversible effects of climate change will occur, land and ocean temperature change, sea level rise and ocean acidification, loss of Arctic Sea ice and ice sheets, stronger storms, longer heatwaves and droughts, abrupt precipitation mainly intensity and seasonal distribution, thawing permafrost and more (IPCC, 2013). On the basis of the Sixth Assessment UN Secretary-General António Guterres said “The alarm bells are deafening, and the evidence is irrefutable: greenhouse gas emissions from fossil fuel burning and deforestation are choking our planet and putting billions of people at immediate risk.” According to the United Nations (2015), there are still 836 million people in the world living in extreme poverty (less than USD,1.25/ day). And according to the International Fund for Agricultural Development (IFAD), at least 70% of the very poor live in rural areas, most of them depending partly or completely on agriculture for their livelihoods. It is estimated that 500 million smallholder farms in the developing world are supporting almost 2 billion people, and in Asia and sub-Saharan Africa these small farms produce about 80 percent of the food consumed (IFAD, 2011). The rural poor often depend partly on forests for their livelihoods (World Bank, 2002). It is estimated that between 660 and 820 million people (workers and their families) depend totally or partly on fisheries, aquaculture and related industries as a source of income and support (HLPE, 2014).

Veterinary ultrasonographer has to write report of ultrasonography in different animals. The proper ultrasound report writing is the moral duty of the vet ultrasonographer. The accuracy of diagnosis must be ensured. The poor resolution/quality of machine may lead to erroneous diagnosis. Therefore, veterinarian must ensure good quality of machine and proper diagnosis. The report might be different in different animals e.g. report writing about uterus will be different in bitch, cows, buffaloes, camel, horse, goat and sheep. However following might be guidelines in writing ultrasound report of uterus. fetus, endometrium

Uterus: Position of uterus, contents in the uterus, shape and size in initial pregnancy and infections, appearance of myometrium, thickening of uterine layers, presence or absence of fluied/pus/masses, left and right horns and their contents. Observations on the images of uterine fluid and its echoicity, membrane appearance in pregnant animals. Special attentions should be paid to endometrium.

Endometrium: Appearance and thickness; any growth on the surface of endometrium. Images of retained portion of placenta can be ascribed in the cases of retained placenta.

Ovary: Ovaries are scanned to assess cyclic structures, size, shape, its Position/ location and internal echo pattern of follicles. This echo pattern will indicate whether follicle is normal, cystic or with any other abnormalities of follclular f luid. Ultrasound reports also include shape and size of corpus luteum. In cows and buffaloes, presence of cavity, looseness/compactness of luteal cells are also mentioned.