eChapters

This chapter focuses on the statistical methods used for method development. These are categories as follow :

1.SUPAC- Scale-Up and Post-Approval Changes

2.PAT -Process Analytical Technique

1. SUPAC - The acronym “ SUPAC “stands for “Scale-Up and Post- Approval Changes” . It refers to the FDA-recommended testing and filing actions to be taken by a pharmaceutical firm when it changes the manufacturing processes of a drug product that has been approved via a New Drug Application (NDA), an Abbreviated New Drug Application (ANDA), or an Abbreviated Antibiotic Drug Application (AADA). FDA has provided its recommendations to industry in the form of SUPAC Guidances or supac guidelines.

Physiotherapy may be defined as the use of physical techniques like massage, exercise, heat, cold, sound waves, electric current etc for the treatment of injuries and movement dysfunction. Physiotherapy deals with the treatment of diseases by physical methods. It is used for treating injuries, strain, spasm, painful conditions, sprain of tendons, paralysis, postoperative trauma etc. It improves functioning of nerve, muscles and bones. The aim of physical therapy is the restoration of function and promotion of tissue healing by assisting normal physiological processes. The physiological response to physical therapy is its effect on the vascular supply; this in turn reproduces similar changes in deeper tissues.

Food provides a sense of wellbeing and comfort and makes people feel good. In this world of a growing population, the need for affordable, safe and good quality food is rising constantly. On the other hand, there is growing awareness of customers who demand that food be produced and supplied hygienically in socially responsible and eco-friendly ways.

Introduction

During the intensive system of poultry production birds are exposed to several types of stresses. The birds can tolerate mild stress but when the stress is severe, there is imbalance between oxidants and antioxidants which lead to oxidative stress and lipid peroxidative damage of tissues, ultimately results in poor performance. Nutrition has a strong impact on oxidative stress. Insufficient intake of antioxidants, a high intake of prooxidants, or both may lead to oxidative stress. The detrimental effects of oxidation process can be prevented by addition of antioxidant compounds in the feed. Vitamin E, carotenoids and selenium (Se) are among important antioxidant components of poultry diets. It is important to understand the role of antioxidants in poultry nutrition in general and in production and reproduction in particular. The chapter, here in will discuss the stressors in poultry production, oxidative stress and possible alleviation through dietary antioxidant supplementation.

In general, any business directly involved in food production can be certified, including seed suppliers, farmers, food processors, retailers and restaurants. Requirements vary from country to country, and generally involve a set of production standards for growing, storage, processing, packaging and shipping organic certification ensures:

• Avoidance of synthetic chemical inputs (e.g. Fertilizer, pesticides, antibiotics, food additives, etc) and genetically modified organisms;
• Use of farmland that has been free from chemicals for a number of years (often, three or more);
• Keeping detailed written production and sales records (audit trail);
• Maintaining strict physical separation of organic products from non-certified products and
• Undergoing periodical on-site inspections.

In some countries, certification is overseen by the government, and commercial use of the term organic is legally restricted. Certified organic producers are also subject to the same agricultural, food safety and other government regulations that apply to non-certified producers.

Economic Importance of Rodent Pests

• They consume and damage foods in the fields and in stores. In addition, they spoil it in store by urine and droppings reducing the sale values.
• Due to their gnawing and burrowing habit they destroy many articles (packing, clothes and furniture) and structures (floors, buildings, bridges, etc). By gnawing the electrical cables they can cause fires.
• They are responsible for transmitting diseases dangerous to human and domestic animals.

Among many pests of agricultural crops and stored grain products, rodents are the major pests which do the great damage. Rodents including rats, mice and squirrels are gnawing animals having chisel like teeth. They have highly developed sense of smell, taste and hearing. They are omnivorous and feed on grains, vegetables, fruits, meat and other products in the houses or in the fields. Rats daily consume food equal to about 10 per cent of their body weight and the figure may go up to 30 per cent in case of mice. Rats are among the most destructive pests of paddy in the field causing about 5-10 percent damage. It is estimated that these animals destroy 30 per cent of the total world’s cereal production. In India, 10 million tonnes of food grains are lost every year. It is often said that if rodent ravages could be controlled, a huge amount of food grains can be saved.

Of the 84 species of order Rodentia in India, 50 belong to family Muridae. The important ones belong to two sub-families, viz., Murinae and Gerbillinae. Murinae has 18 species of genus Rattus, 2 of Bandicota, 7 of Mus, 2 of Apodemus and a few each under eight other genera. The sub-family Gerbillinae has 2 species of Gerbillus, one each of Tatera and Meriones. Family Sciuridae has 10 species of flying squirrels and 13 species of tree squirrels in India.

Liver is situated in cranial abdomen. Scanning of abdomen is started with the examination of liver. Hepatic ultrasonography is a non-invasive diagnostic modality to evaluate liver parenchyma. Differentiation of focal disease from diffuse disease, cystic lesions from solid masses, and obstructive jaundice from non-obstructive jaundice is possible by hepatic ultrasonography.

Abstract

Recently, the reduction of post harvest food losses around the globe is a critical issue for ensuring future food security. Drying techniques is important option to prevent losses and preserve food for long time. The solar thermal energy required to remove moisture from the food during the drying process can be optimized by designing suitable solar dryers. Moreover, the application of solar energy in drying of agricultural products has tremendous potential, since it can easily provide the low temperature heating required for drying and helps in reduction of CO2 emissions. Hence, the present chapter deals with descriptions of different types of solar dryers used to dry various types of agricultural food products and design of solar dryers. Also, the heat and mass transfer parameters with respect to various process variables to estimate the performance of the food dryer system were analyzed. The advantages of solar dryers in terms of net CO2 emissions mitigation potential and the quality attributes of dried food products are also discussed. It is suggested that properly designed solar dryers having low operational cost compared to electrically heated dryers may prove to be an energy saving device for drying of agricultural products. However, the techno-economical and environmental aspects of various efficient solar dryers are needed to be further studied for applications in various irregular shaped food products.

Computer-based instructional teaching and learning platforms, commonly known as Learning Management Systems (LMS) or educational technology (EdTech) platforms, are designed to enhance the educational experience by integrating technology into the learning process. These platforms offer a range of tools and features that support both instructors and students in various educational activities. Here are some key platforms and their features:

Key Platforms

Moodle

Moodle (Modular Object-Oriented Dynamic Learning Environment) is a widely used open-source Learning Management System (LMS) designed to provide educators, administrators, and learners with a robust, secure, and integrated system to create personalized learning environments. Here's an in depth look at Moodle, its features, and its use cases:

Key Features of Moodle

1. Course Management

• Customizable Course Creation: Instructors can design courses with f lexible layouts, multimedia content, and varied activities.

• Modular Plugins: Extensive library of plugins for activities, resources, and user management

INTRODUCTION

Indigenous knowledge is the knowledge of the indigenous people inhabiting different geographical regions of the world with their own language, culture, tradition, belief, folklore, rites and rituals. In course of their close interactions with nature and natural resources, they are to make a certain decisions as to solve their problems they encounter in their day to day life while managing the land and environmental resources for survival.

Several researchers explained traditional knowledge as holistic, encompassing many fields of scientific knowledge, such as climate, hydrology, soils, plants and animals (Howes and Chambers, 1980, Jungerius, 1985, Wilken, 1987, Agrawal, 1995). Therefore, indigenous knowledge so developed is based on necessities, instinct, curiosity and observations of ethnic groups to mitigate the immediate problems. Several logical observation was used by them in the decision making process as to how, when and where to act depending on the situations.

Introduction

Food being the foremost basic need gets the priority in expenditure of people, especially poor class. Access to food demands affordability, which depends upon the twin factors namely, income of the people and prices prevailing in the country. Slower growth in income than prices would undermine the purchasing power, resulting in inadequate access to food and calorie consumption. Foodgrains account for about four-fifth of the calorie intake of the poor and an increase in cereal prices could significantly reduce the calorie intake of the poor, as it is sensitive to cereal prices.

19.1. Remedies to Combat Unemployment in Nigeria

(a) Rural development

One way of stemming the rural-urban drift, and thus control the resulting unemployment in our urban centers, it for the government to develop the rural areas. Not only should amenities be provided, but jobs should be created in the rural areas to stem the exodus. Fortunately, the Babangida administration seemed to have realized this with the huge amount allocation for the development of rural areas in the 1986 and 1987 budgets.

(b) Population control

Government must intensity the effort to control population growth Nigeria already has a huge population and with an estimated growth rate of about 3 percent annually, this can only compound the unemployment in the face of inadequate resources. It is therefore advocated that the government should renew the family planning campaign to check the population growth.

Remote sensing and Geographic Information Systems provide spatial information for monitoring crops, land, soil and water resources. This chapter introduces their fundamental principles and explains developments involving satellites, UAVs, hyperspectral sensors, thermal imaging and cloud-based geospatial platforms. Analytical techniques include vegetation indices, time-series analysis, spatial modelling and artificial intelligence. Applications cover crop-health monitoring, yield forecasting, irrigation planning, drought assessment, pest and disease identification and soil-resource management. Integration with IoT, automation and other digital technologies improves the timeliness and resolution of agricultural information. These tools support evidence-based decisions responding to food-security, climate-change and natural-resource sustainability challenges.

Abstract
 
Drying is one of the most popular methods used for preserving products and extending their shelf lives by reducing moisture content to a low level to prevent microbial spoilage and moisture-mediated deteriorative reactions. As an efficient technology with high heat and mass transfer rates, impingement drying has been commonly used in various industrial drying such as tissue paper, textiles, photographic films, coated paper, nonwovens, carpets, lumber etc. In the past two decades, air impingement technology has got more and more attention in the field of food and agricultural products processing.

The concept of origin of cultivated plants was first developed by A de Candolle and the geographic centres of variability were developed by Vavilov. He identified Asia as a major centre with “Indian centre” of North East region as primary or secondary centre of origin for many crop plants. Plant genetic resources are of great importance as they form the basic raw materials to meet the current and future needs of crop improvement programmes. A wider genetic base, thus, assumes priority in plant breeding research aimed at developing new varieties for increased crop production (Paroda, 1991). This diversity comprises of native landraces, local selections, elite cultivars and wild relatives of crop plants. The collection and conservation of this diversity in a systematic manner is the primary responsibility of all plant genetic resources institutes/centres. The mention of use and cultivation of fruits can be seen in epics like ‘Ramayana’. Plant genetic resources are thus our heritage, which need conservation for posterity. During the long period of domestication, utilization and cultivation, a wide array of fruit crop variability got generated by natural means and through both conscious and unconscious selection. Huge wealth of variability also got generated/adapted and diversified by crop introductions in the exotic environment or through migration of human population.

Since commencement of the settlement of world, the search for food had been uppermost, thereby, practising the conservation of food is a basic need for ensuring its ample supply to human being. The problem of food storage is growing fast day by day with the increase in the population. The existing shortage of protein and caloric requirements will not only be solved by growing more food and resorting to family planning measures but also by saving the produce from deterioration and wastage, and its efficient allocation to meet the growing requirement of population. In countries with varied climatic conditions, it is a steady struggle of man with insects, mites, rodents and microbes in getting the food stuff.

Need and Objectives of Storage

Since times immemorial, man adopted a particular system of storage and certain produce storage standards. Some of the storage methods are still in use in several regions, in the capacity varying from one kg to several hundred quintals, like hollowed gourds, skin bags, mud bins, excavated stones, woven baskets, underground pits etc., particularly in the tropics. The problems of storage in developing countries are more acute than that in well developed countries and a considerable disparity seems to be there in food availability. All need a food supply that should be nutritious, clean; free from insects, rodents, birds, other animal filth and harmful chemical residues. There are two types of needs, one immediately after harvest and the other in off season. There is no need of storing the produce for immediate requirement but for the latter case, the need to conserve produce properly is inevitable. Further, the need for storage has always arisen for one reason to distribute commodity in deficit production areas and the other based on improved quality standards. In all the way, therefore; growers, processors, transporters and warehouse owner must assist to comply with these requirements.

Introduction

The Indian fisheries sector is set in a unique and diverse set of resources ranging from the pristine waters of the Himalayas to the sprawling Indian Ocean. The fisheries biodiversity of the country encompasses a wide spectrum of physical and biological components that support the livelihoods of millions of people. Fisheries resources are set in different ecosystems. With growing population and the increasing demand for fish protein, the need for sustainable development of aquatic resources is now felt much more than ever before.

Fisheries and aquaculture remain important sources of food, nutrition, income and livelihoods for hundreds of millions of people around the world. Global capture and culture fish production during 2019 were 97 and 82 million tonnes, respectively with India being second largest producer of fish in the world after China. From 0.75 million tonnes in 1950-51, total fish production of India touched 12.59 million tonnes in 2018-19 with a contribution of 8.90 million tonnes (70.60%) from inland sector. The sunrise fisheries sector contributes about 0.96 % to National Gross Value Added (GVA) and 5.37% to agricultural GVA (2018-19) while engaging over 14.5 million people (2003 census) at the primary level and almost twice the number along the value chain. During 2018-19 the export of marine products that includes production from aquaculture reached 13,77,244 tonnes valued at INR 46589 crore (US $ 6.93 billion). The inland sector grew at a compounded annual growth rate (CAGR) of nearly 6.5% between 1979 and 2018, while overall fish production witnessed 4.5% growth, which is double the growth rate of food grains production in India.

Pigeonpea (Cajanus cajan, (L.) Millspaugh, 2n = 2x = 22, an often crosspollinated crop with 20 – 70% cross-pollination, family-pea family Leguminosae or Fabaceae, genome size 808 Mbp) is a short-lived perennial shrub that is traditionally cultivated as an annual crop in developing countries.. It is grown in Asia, Eastern and Southern Africa, Latin America and Caribbean countries. On an average, it is cultivated worldwide on 4.92 million hectares (M ha) with an annual production of 3.65 Mt giving a productivity of 741 kg/ ha. India is the largest producer followed by Myanmar and Eastern and Southern Africa (principally Mozambique, Malawi, Tanzania, Kenya and Uganda.

1.1 Perspective

From the very dawn of evolution of human beings, man has been using plants as food, for wellness and as medicine to alleviate diseases and discomfort. People living in different parts of the world, both new and old, in the centres of some of the oldest civilizations, had selected organisms from time immemorial for food and medicine by a process of trial and error or even by experimentation with the biological resources, particularly among the plants growing around them. These have been referred to as ethnic food/traditional food and ethnic medicine/traditional medicine. India is one of the mega centres of biodiversity, and that of the ethnic diversity, that evolved over millennia with settlement of diverse races coming from different regions of the world, besides the indigenous people. Thereby, it inhabits some of the most diverse cultural traditions. This process has led to further evolution of some of the oldest indigenous civilizations originated in the Indian Subcontinent with amalgamation of exotic traditions and the knowledge. Integration of the knowledge associated with the use of plants with medicinal properties has enriched its great heritage of medicinal plant use, the Ayurveda, i.e., the knowledge of life and longevity, dating back to the pre-historic and the early Vedic period.