eChapter Name: A Fascinating Decade for the Various Approaches to Creating A Library of Building Fragments Based on the 1,2-Azole
9789372193862
eBook Name: FRONTIERS IN ORGANIC CHEMISTRY RESEARCH AND ADVANCES
by Rama Kanwar Khangarot, Gangotri Pemawat
Introduction and Applications of 1,2-Azoles
Interest in the chemistry of 1,2-azoles has grown significantly over the last ten years, mostly due to the discovery of intriguing features shown by a large number of 1,2-azoles derivatives. 1,2-azoles, which are five-membered heterocycles with nearby nitrogen and heteroatoms (X = N, O, S), are highly prized in organic synthesis by using heterocyclic substituents that contain nitrogen, sulfur, or oxygen, the five-membered ring system’s biological activity and bioavailability can be improved. Functionalized pyrazoles, isoxazoles, and isothiazoles are found in a large number of naturally occurring and synthetically produced medicinally relevant molecules (Chakroborty et al., 2013, Preeti et al., 2018). Numerous biological actions are exhibited by these molecules (Pathak et al., 2012, Yan et al., 2007, Ruan et al., 2012, Katritzky et al., 2001, Shaw et al., 2012, Waldo et al., 2007, Uramaru et al., 2010, Cutri et al., 2004). A few examples of molecules with this structural pattern are shown in Figure 1. Table 1 lists the uses of 1,2-azoles in medications, agrochemistry, natural products, and pharmaceuticals.