eChapters

Homeopathic Prescription

A basis for homeopathic prescription involves identifying all the aspects of the case (detailed questioning to get the history in respect to animal, its behavior, its nutrition and management, vaccination and deworming status, past and present illness etc.), objective investigations (instrumental and laboratory), coupled with an overview of the picture and dynamics of the patient (it is more philosophical and subjective).

In recording symptoms (both present and past), special attention is to be paid to peculiar symptoms, mental state and generalities. Then appropriate remedy is selected through a process called “reportization”. After selecting an appropriate remedy, its correct potency is determined. Selection of the potency depends on the strength of vital force of the ailing individual, degree and extent of physical pathology and disease chronicity (Hahnemann,1994). Higher potency is selected if vital force is strong. For example higher potency are more suitable for young and growing animals. If tissue pathology is more, lower potency drug is advisable. The effect of higher potency drugs is for greater period of time. Effect of 1M potency may last for a month while that of 30C potency may last for a week. If pathology is not severe, 200C potency may be selected. In case pathology is significant, potency below 200C may be chosen. For weak and emaciated animals, potency 30C or below is advisable. Clear cut cases with strong mental symptoms are right candidates for high potency. Unclear case should be given low potency drug (Pitcairn, 1992). As soon as relief is observed, the drug administration should be stopped. Overmedication is the great error in homeopathic prescribing. In homeopathic prescribing, number of pillules taken in a single dose is less important. What matters is its potency and frequency.

Homeopathy

The word ‘Homeopathy’ is derived from two Greek words “Homeos” and “Pathos” meaning “similar” and “suffering” respectively (Mukherjee and Wahile,2006). This system of medicine is based on the principle of ‘Similars’ propounded by Dr. Samuel Hahnemann in late 17th century. The practice of Homeopathy came into being and gained wide spread popularity too early in the history of medicine at a time when it was impossible to provide any kind of explanation for its clinical efficacy. It is a complete and separate approach to health care using dynamized micro doses of herbs, minerals or animal products to stimulate the body’s innate healing mechanism. Homeopathy is claimed to be more ecological, compassionate and comprehensive owing to use of micro doses. Clinical anecdotal evidence exists to indicate that homeopathy is beneficial in veterinary practice also. The homeopathic remedies stimulate the body defense to heal itself. The practice of homeopathy began first and science in its efficacy is being discovered later as was in case of immunology. An increasing interest is being shown in Homeopathy as a complementary and alternative treatment for both human and animal diseases owing to ever increasing problem of emergence of resistance in micro-organisms to antibiotics, their residues in animal products, and side effects of modern drugs. But critics of homeopathy are not reconciling with the use of highly diluted homeopathic remedies and considering it as a controversial therapy. Researches with the help of modern technology are now illustrating science in homeopathy.

Bengal. Introduction
Homeostasis is unlike any time control process because it involves a very complicated relationship between fundamental knowledge of balance and coordination that ensures existence and performance of all creatures. It is in fact one of the major functioning mechanisms of biological systems, which allows them to sustain stable internal surroundings regardless of outside changes. This regulatory system is essential for evolutionary survival
as well as physiological balance. At the same time, time management-often viewed in terms of human productivity-plays an important part in biology by influencing biological clocks and circadian rhythms. In order to be healthy, behavior and species evolution, physiological processes have to synchronize their daily and seasonal changes caused by environment factors. At first glance, these two concepts seem to be unrelated; but if
viewed from the perspectives of biology and evolution, it becomes clear that they are deeply connected. These include temperature levels, pH values, and glucose concentrations among others that need to be maintained if life has to exist: homeostasis is necessary in order to keep these conditions stable. On the other hand, biological systems rely on time management especially through circadian rhythms so as to schedule diverse activities like feeding, sleeping metabolism or reproduction.This introduction describes how an organism manages to control and regulate its internal processes in conjunction with environmental stimuli is what makes it possible for organisms to live long, and perform productive activities and also enjoy a healthy life.In the year of 1926, Walter Cannon coined the word “homeostasis” with reference to a process through which all organisms maintain stable internal environments regardless changes happening outside their bodies. The theory’s cornerstone was Claude Bernard’s proposition of ‘milieu intérieur’, meaning moderate conditions needed for the existence of an organism itself the basic concept of homeostasis in physiology consists of the complex regulatory mechanisms regulating temperature, glucose metabolism, water balance, pH levels and other systems. Restoring equilibrium
is achieved through perturbations that trigger some reactions from a reference point and mostly these are negative feedback loops for homeostatic processes. For instance, when pancreatic cells secrete insulin into the bloodstream after a meal because there is an incr

Even while the world is ageing, it is not prepared for it. There are 962 million people over 60 in the world as of 2017 with 310.0 million of them living in wealthy countries and 652.2 million in developing ones, according to data from the UN's Department of Economic and Social Affairs (DESA-UN 2017). According to projections, there would be 2.1 billion seniors worldwide by the year 2050 (rich countries: 421.4 million, developing countries: 1670.5 million). By 2030, 80% of the old people in the globe will live in developing countries (DESA-UN, 2015). Elderly individuals in rural developing countries confront challenges such as the lack of pension coverage, work difficulty and high medical costs. Their poor diets and deteriorating poverty raise their risk of chronic illnesses like diabetes, heart disease and cancer (Marshall et al., 2001). 

The homoeopathic materia medica consists of around 1000 drugs, the characteristics of which have been verified or proved. Homoeopathy is unique in that it uses no drug, which has not been proved. The proving has been done by administering pure medicines to healthy human beings and recording in minute detail the effects, mostly adverse, produced by such administration. The tests were conducted on men and women who were mostly medical people and students who were not sick. The drugs were administered in doses consisting of crude drugs or homoeopathic potencies. These volunteers were then asked to describe the effects of the drugs in their own words. These descriptions were noted down by the doctors conducting the experiments and were carefully recorded. Hundreds of thousands of such symptoms were recorded while proving the homoeopathic drugs and the materia medica forms a record of the best proving along with other data collected as a result of laboratory tests and experiments.

In paragraph 25 of the 'Organon of medicine', Dr.Samuel Hahnemann the founder of the system laid down the basis of homoeopathy in the following words: "Now, however, in all careful trials, pure experience, the sole and infallible oracle qi healing art, teaches us that medicine which, in its action on the healthy human body, has demonstrated its power of producing the greatest number of symptoms similar to those observable in the case of disease under treatment, does also, in doses of suitable potency and attenuation, rapidly, radically and permanently remove the totality of the symptoms of this morbid state, that is to say the whole disease present, and change it into health; and that all medicines cure, without exception, those diseases whose symptoms most nearly resemble their own, and leave none of them uncured."

Dr. Samuel Hahnemann laid down the fundamentals of the then new doctrine of homoeopathy in organon of medicine. As observed by him in the 'Introduction⁷ to this work, till then no one had ever taught this homoeopathic mode of cure, no one had carried it out in practice.

Dr. Hahnemann was of the view that the art of the medical practice "should. Rapidly and mildly, effect an unalloyed and permanent cure, and restore to health by means of the smallest doses of a few simple medicines carefully selected according to their proved effect, by the only therapeutic law comfortable to nature, that is Similia Similibus Curentur".

Homoeopathy is based on the following principles:

"The physicians high and only mission is to restore the sick to health, to cure, as it is termed"

The highest ideal of cure is rapid, gentle and permanent restoration of health or removal and annihilation of the disease in its whole extent in the shortest, most reliable and most harmless way on easily comprehensible principles.

Unprejudiced observer of a sick person takes note of nothing in every individuars disease except the changes in the health of the body and of the mind, which can be perceived externally by means of the senses. "All these perceptible signs represent the disease in its whole extent, that is, together they form the true and only conceivable portrait of the disease"

Homoeopathy system of medicine is the system of healing suited to all the young, and the old, the rich and the poor, the people in the developed as well as the underdeveloped countries and for persons in any place or climate. This is not to take away from the value and utility of the other prevalent systems of medicine. The aim of every science of healing is the relief of sick. Every system is successful in its own fashion. Homoeopathy too fights sickness and does so with remarkable results. Additionally the cost of diagnosis in this system is negligible because the diagnosis is by and large symptomatic. The medicine itself is inexpensive. Notable efficacy and low costs are the strong points of homoeopathic medicine. There are no toxic effects of the drugs, no side effects. The time taken for the medicine to show improvement is not long. Homoeopathic medicines are easy to store and have a long life.

Homoeopathy has been attacked again and again on the ground that the potencised drugs cannot be tested in a laboratory. But that way a number of phenomenon is still outside the pale of conventional science. However, laboratory tests have been going in many countries and certain phenomenon not acceptable to conventional scientific beliefs have been observed.

The homoeopathic system of medicine develops for its special use, the inner medicinal powers of the crude substances by means of a process peculiar to it and which has never been tried, whereby they only all become immeasurably and penetratingly efficacious and remedial. Even those that in the crude state give no evidence of the slightest medicinal power on the human body.

This remarkable change in the qualities of natural bodies develops the latent, hidden powers, which influence the body, change the well-being. This is affected by mechanical action upon their smallest particles by means of rubbing and shaking and through the addition of an indifferent substance, dry or fluid. This process is called dynamization; potencizing and the products are dynamizations or potencies in different degrees.

11.1 Introduction
“Homogenization” is the method of mechanical treatment producing a stable emulsion of milk fat and milk serum. Homogenizer is the name given to the equipment employed for this aim. The fat globules in milk range in size from 1 to 20 microns; the average is 4 to 6 microns. The homogenizer reduces the size of the fat globules in milk or cream passing through it. The most of them are less than two microns. After homogenization, no cream line develops on milk; churning homogenized cream cannot generate butter grains. Moreover, milk like cream’s viscosity is changing, which increases the resistance the smaller fat globules face. The increase in viscosity is ascribed to the fact that more milk protein will be deposited on the surfaces of more fat lobules. Homogenizing milk changes its clotting characteristics, so the curd made with rennet or pepsin is supposed to be softer. Because lipolytic enzymes adsorbed on the extra surfaces provided by the more numerous tiny fat globules hydroly fat, homogenized milk or cream may become rancid more quickly than untreated goods. The milk or cream must be pasteurized either right before or right after homogenization to prevent these changes. Usually, the milk is homogenized after main heating and then pasteurized. Driven via a small valve against hard surfaces, heated milk is under pressure of 2500 psi and in a second stage under 500 psi. With a 1/10000 inch diameter, the aperture the liquid is driven through is quite small. Mechanical force milk through a narrow passage at high speed produces homogenized milk. This produces a stabile fat emulsion and breaks down the fat globules in milk into considerably smaller ones. Homogenization reduces the inclination of the fat globules to cluster and merge into cream. Milk is an emulsion whereby fat globules are distributed across a constant skim milk phase. Raw milk left to sit will finally cause the fat to climb to the top and form a cream layer. By means of a small opening under high pressure, homogenization mechanically breaks down the fat globules. While increasing their number and surface area, this lowers the average size of the fat globules. Practically speaking, the net effect is a substantially decreased inclination for creaming of fat globules. Three elements contribute to this increased stability of homogenized milk: a decrease in the mean diameter of the fat globules (a factor in Stokes Law), a decrease in the size distribution of the fat globules (causing the speed of rise to be similar for most globules such that they do not tend to cluster during creaming), and an increase in density of the globules (bring them closer to the continuous phase) owing to the adsorption of a protein membrane. < Heat pasteurization also breaks down the cryo-globulin complex, which often clusters fat globules causing them to increase. The homogenizer consists of a high-pressure pump with an adjustable opening based on a minute orifice. High pressure force of fluids through the orifice causes a notable change in the physical characteristics of the treated product and generates a very intimate combination of the fluid components. Annexure- II has a Homogenizer schematic.

1. Introduction

Raw milk is an emulsion. It is a mixture of milkfat globules, Solid Not Fat (SNF) and water. Over time, milkfat globule separate out from milk serum and comes to the surface of milk as a layer of cream due to the low density of milkfat or due to heating of milk. When milk is heated rapidly and continuously, some of the water in it evaporates from the surface. This exposes proteins and fat molecules, which bind and dry out and forms a skin like film on the surface. 

ABSTRACT

The Cry2A proteins are promising candidates for managing the development of Cry1Ac resistance in insects. The Cry2A class of proteins is different from that of Cry1A, and experiments have shown that insects resistant to Cry1Ac are not cross-resistant to Cry2A proteins. However, the Cry2A proteins are less toxic than Cry1Ac to the polyphagous pest Helicoverpa armigera. Structure-based protein engineering of Cry toxins may pave the way for directed evolution of variants with broad spectrum of insect species specificity, enhanced potency, and stability. In the present study homology modeling of Cry2Ac was done using DeepView software. The template for Cry2Ac protein sequence (accession number X57252) was selected using ExPdb template search. The raw sequence of the Cry2Ac was superimposed over the Cry2Aa PDB template (1I5P). The superimposed model was submitted to the SWISS Model server. After receiving the Cry2Ac model, energy minimization was done using Gromos96. The threading energy and force field energy were calculated. The homology model of Cry2Ac made by us along with the Cry2Ac model from the SWISS-MODEL Repository was used for comparative analysis of receptor binding regions of Cry2Aa. Results showed variation between the two highly homologous Cry2A proteins in their receptor binding regions which may account for differences in spectrum of insecticidal activity.

Abstract

When only sequence data is available, homology modeling has become a useful tool for predicting protein structure. Protein structure is often more important than sequence data when evaluating protein function. Homology modeling, also known as comparative modeling, is based on the principle that two sequences that exhibit a high degree of identity or similarity will also share similar structures. This chapter explores the steps involved in homology modeling, including template selection, alignment, model building, refinement, and validation. The Ramachandran plot is a valuable tool for assessing the conformation and bond angles in a protein model, and we discuss its significance in the context of homology modeling. Ultimately, homology modeling is an effective method for predicting protein structure and has numerous applications in protein engineering, drug discovery, and other fields.

Since bees are indicator species, their abundance on earth serves as a barometer for environmental conditions and the health of ecosystems. With up to 60,000 honey bees living in a single hive, each with a distinct job, the life of a bee is undoubtedly one of nature’s greatest miracles. There is much to be learnt from the exquisitely smart, well-organized lives of bees. Around the world, honey bee hives have been experiencing severe decreases over the past ten years, and local pollinating species are also experiencing significant losses. A growing number of studies point to a particular class of pesticides as the principal cause of the worldwide pollinator disaster, and if our government agencies and certain legislators don’t act quickly, the pollinator situation will only get worse.

Rachel Carson written Silent Spring 50 years ago, she expressed her concerns about the use of systemic insecticides like neonicotinoids. We are currently seeing f irst-hand how her forecasts come true

“The world of systemic insecticides is a weird world, surpassing the imaginings of the brothers Grimm… It is a world where the enchanted forest of the fairy tales has become the poisonous forest in which an insect that chews a leaf or sucks the sap of a plant is doomed. It is a world where a flea bites a dog, and dies because the dog’s blood has been made poisonous, where an insect may die from vapors emanating from a plant it has never touched, where a bee may carry poisonous nectar back to its hive and presently produce poisonous honey (Rachel Caron, Silent Spring)”.

Synonym – Cutaneous ancylostomiasis

Etiology

Hook worm dermatitis is uncommon or rare skin disease due to larval migration of the normal life cycle of Ancylostoma braziliensis and Ancylostoma caninum. It is mainly due to hypersensitive reactions against migrating third stage larvae in the distal extremities.

Introduction

In the perspective of the accelerating national growth rate of 8% recorded at the end of the 10th Plan to a projected growth rate of 10% by the end of the 11th Plan, yielding an average GDP growth rate of about 9% it was appearing that the nation is going to have a strong footing of development. However, it could not be fully achieved due to several reasons including the global recession and other factors related to international economic setback which may deter achieving a projected growth rate of 10% in the 12th Plan. In consideration of the international scenario of growing complicacy in economic growth more emphasis should be given on further efficient utilization of natural resources and intellectual properties of grass root innovators to improve per capita income leading to a promising national structure of economics ensuring wide spread benefits to the society. In this regard, true development of a nation like India can be primarily realized by recognition of wide spread enthusiasm of its innovative human resources living in village and rural areas. It can be made possible only through working with them by appreciating their struggle for survival using all round innovative measures coming out of their daily life experiences and traditional knowledge. Technopreneur Promotion Programme (TePP) is a unique scheme of Government of India for development of society especially by promoting the intellectual properties of grass- root level innovators coming out from the society with a source of inspiration arising out of their daily life struggle for existence. In spite of its limited publicity in remote areas an awareness of this programme has often been found to raise great hope to the villagers to do something for their society exploring the ideas generated from the experiences of life with the help of local resources. Such naturally grown innovation can be found undoubtedly novel and the idea can change their world of dreaming for a more prosperous life by bringing changes in socioeconomic pattern of trade and employment in rural areas with proper support from Government if India through the scheme like TePP.

The number of hormones secreted by the body exhibits control over the physiological regulation of glucose sugar level (homeostasis) in the manner needed by the body. Depending upon the situation, hormones may increase or decrease the level of glucose sugar present in the blood or tissues. The glucose is oxidized to yield energy, carbon dioxide, and water.
Glucose, more than the body’s needs, is stored or converted mainly to glycogen and, to some extent, protein and fat. If glucose is less than the need of the body, its denovo synthesis takes place from amino acids or fatty acids, or is formed from the breakdown of stored glycogen. Various hormones are secreted by multiple endocrine glands to control the blood glucose level. If it fails, it leads to hypoglycemia or hyperglycemia conditions. Gluconeogenesis is not developed at birth in the case of a baby pig. Therefore, hypoglycemia in baby pigs is observed within 2 days of age if starved, leading to hypoglycemia, weakness, confusion, and death.
15.1 The Hormones Involved in Homeostatic Regulation of Blood
Glucose Level
The hormones influencing carbohydrate metabolism are explained below:

Introduction

During transition period and lactation, the high-producing dairy cows undergo a period of extensive tissue catabolism because of negative nutrient balance. Homeorrhetic mechanism at this stage ensures that nutrients are partitioned to favour the growth of fetus prepartum and meet the demand of nutrients in early lactation. Simultaneously the homeostasis secures survival of the animal body functions. However, a decline in feed intake in transition period leads to metabolic disturbances and low milk production in early lactation. The postpartum negative nutrient balance impairs immune and reproductive functions in dairy cows and buffaloes. The increased demand for nutrients and decreased dry matter intake results in low circulating glucose and insulin levels and elevated non-esterified fatty acids (NEFA) and ketone bodies postpartum. The energetic status of a cow or buffalo modulates the secretion of hormones that play key roles in growth of ovarian follicles, ovulation, corpus luteum (CL) formation, and oocyte competence. The NEBAL not only limits milk production potential but also has a detrimental effect on immune cells. Negative nutrient balance is associated with changes in the pattern of ovarian follicle growth and oocyte quality and alteration in endocrines. In addition, cows under negative nutrient balance have extended periods of anovulation. These changes could be minimized by supplementing energy rich supplements like prilled fat or any bypass fat preparations.

1. INTRODUCTION

In plants, seed dormancy is controlled by temperature, light and hormones. Unlike animals, which secrete hormones from special glands, hormones are always present in plant cells. Each plant hormone plays multiple roles, depending on the site of action, the life stage of the plant and the hormone’s concentration. A plant hormone is any chemical that is produced in one part of the plant that has a targeted function elsewhere. Certain hormones induce and keep seeds in a dormant state, while others cause seeds to break dormancy and initiate germination They are stored in regions where stimulus are and then released for transport through either phloem or mesophyll when the appropriate stimulus occurs. These are chemical messengers influencing many patterns of plant development

The first theory is that the five classic plant hormones, auxin, cytokinins (CKs), gibberellins (GAs), ethylene, and abscisic acid (ABA), plus the new plant hormones, brassinosteroids (BAs), and salicylates or salicylic acids (SAs) can be gathered into three groups. These are growth hormones, stress hormones and shock hormones. Auxin and CKs are growth hormones. Ethylene, GAs, and brassinosteroids are stress hormones. ABAs and SAs are shock hormones. All three types of hormones are similar in that they fall within the classic definition of an intercellular hormone. They are made by a cell and are meant to affect the behavior of other cells, either in nearby tissue or at the opposite end of the plant.

ABA, also known as abscisic acid plays a direct role in dormancy release and germination. Ethylene and the gibberellins group of hormones are indirectly involved.

Introduction

For raising animal and its products especially protein, food and nutrition plays an important role. Feed cost comprises about 60% of total recurring expenditure. Feed additives play an increasingly important role in animal nutrition by augmenting the performance by maintaining the needs of essential nutrients, improving feed conversion therefore optimize feed utilization (Wenk, 2000). Feed additives are a group of feed ingredients that can cause a desired animal response in a non-nutrient role, such as rumen modifier, growth or metabolic modifier (Hutjens, 1991). These are used in micro quantities and require careful handling and mixing. The development and introduction of various new feed additives is a major and practical solution to improve the efficiency of animal production, to alleviate environmental pollution, to maintain animal health, welfare and to ensure the safe and of good quality food production.