eChapters

PART-A

Q1. Elimination of drug is studied under?

1. Pharmacokinetics
2. Pharmacometrics
3. Toxicodynamics
4. Toxicoelimination

Q2. Serpentine receptor is characterized by

1. 7 Transmembrane loop
2. Petals of lilly like structure
3. Zinc fingers
4. JAK STAT

Q3. Status epilepsy is treated best with lorazepm/diazepam

1. Per rectal
2. Intravenous
3. Intramuscular
4. Oral

Present study was embarked upon to extricate the underlying calcium signaling mechanisms responsible for spasmogens (PGF2α , and oxytocin) induced muscular contractions in oviducts of non-pregnant buffalo in oestrous stage. Isometric tension in longitudinal oviductal in both ampulla and isthmus strips was recorded under the resting tension of 1 ± 0.2 g following mounting the tissue in Ringer–locke solution. Following an equilibration period of about 120 to 150 min, oviductal strips both ampulla and isthmus presented a consistent and rhythmic pattern of spontaneity. Mean Integral Tension (MIT) and amplitude (g) of ampulla and isthmus in normal spontaneous tissue did not differ significantly. The frequency (BPM) of ampulla and isthmus in normal spontaneous tissue differed significantly (P<0.05). PG2α produced significantly (P<0.05) greater contraction than oxytocin in both ampulla and isthmus of buffalo oviduct in concentration-dependent manner. In isthmus the contraction produced by oxytocin was negligible. PGF2α produced a significant change in tonic contraction between ampulla and isthmus but the change in phasic contraction between ampulla and isthmus was not significant. PGF2α produced significantly (P<0.05) greater contraction in ampulla than in the isthmus of buffalo oviduct.

Wide hybridization (interspecific/intergeneric) is basically attemped to introduce new genetic variability from wild or distantly related species into cultivated ones or to synthesize new plant type/s like Triticale and Raphanobrassica. Majority of the commercial crop plants are usually deficient for one or the other desirable traits which are usually available in their wild relatives. However, crossability between commercial varieties and their wild relatives is very limited which is naturally imposed by certain genetically controlled reproductive barriers. These reproductive barrier/s usually operate either at pre or post fertilization stage/s in plant species (Stebbins1958). Since a species is constituted of individuals who share a common gene pool, reproduce among themselves only / exchange genes and share a common habitat. Hence at natural level gene flow remains strictly confined only among members of a particular species otherwise among the members of unrelated species a genetic barrier exists to create reproductive isolation. Therefore, wide crossing basically requires the overcoming of such barriers whch are imposed by temporal and spatial isolation of parents. The reproductive isolation consists of premating and post mating isolation mechanisms like habitat isolation or geographical isolation, sexual isolation and mechanical barrier depending upon incompatibility or mismatching of ganitalia (animals). Sexual isolation in animal kingdom is usually enforced by type of sexual displays and mating calls which are attractivce only to particular members of a species , however other potential intermating species also do exist in the same habitat or locality at that particular period of time.

Flower is symbol of beauty and by nature attracts every human being. It is a gift of nature to humanity. Flowers symbolize the quintessence of human spirit. In India, losses are estimated to be more than 30-35%. It is due to the lack of knowledge of postharvest management of cut flowers. Several factors at pre harvest stage including genetic or inherent, climatic or environmental and management harvest factors like stage, method, time of harvesting and postharvest factors such as watering, rehydration, precooling, storage environment, packaging techniques and microorganisms influence the postharvest quality and longevity of cut flowers.

Preharvest factors

1. Genetic or inherent makeup: Postharvest lasting quality of flower species and cultivars vary considerably due to differences in their genetic make up. It is therefore desirable to grow cultivars, which possess long vaselife. 

• Different steps involved in post-harvest processing of horticultural produces are depicted in Fig. 1.

Fig. 1. Flow chart on post-harvest processing of horticultural produces.

6.1. Pre sorting

• Done to eliminate injured, decayed and unwanted produce before cooling and handling.

6.2. Pre cooling

• Removal of field heat after harvest at 32°C for 1 h.

6.2.1. Advantages

• Reduces rate of respiration and ripening, moisture, bruise damage during transits, production of ethylene and growth of spoilage organisms

• Eases load on cooling system (Refrigeration) of transport or storage chamber

A well planned projects requires pre-feasibility study to explore the opportunity to find out problems, avenues of co-ordination etc. A government being a regulation spells out priotize for national and regional economy and by the frameworks for resource allocation.

4.1. Quality of post-harvest product

• Post-harvest quality - market, edible, transport, table, nutritional, internal and appearance qualities

• Consumers consider good quality in relation to colour, flavour and nutrition.

• Final manifestation of inter relation between commodity and its environment.

• Genetic characteristics and physiological status of commodity determine typical post-harvest behaviour and quality of the produce

• Temperature, RH, water potential, light, cultural practices and pest management techniques determine the quality.

4.2. Pre-harvest factors

4.2.1. Related to plants

• Crops: Quality varies from crop to crop E.g. jackfruit, bael, potato, onion, pumpkin, garlic etc. having good quality in relation to shelf life

Introduction

Food is a resource of vital importance and its safety in the whole chain, from producer to consumer, is a worldwide concern. In fact, as food trade expands throughout the world, food safety has become a shared concern among all consumers. This issue began to be taken seriously at a period where there is a significant increase of illness caused by infected food in both developed and developing countries. Unsafe food contains hazardous agents or contaminants that can make people sick, immediately or by increasing their risk of chronic disease. Contaminants can enter food at many different points in the food production process, and can occur naturally or as the result of poor or inadequate production practices. International competitiveness depends more on quality and safety concerns than on prices. Governments and local authorities intervene in the market place in setting technical regulations; and sanitary and phytosanitary measures. This encouraged food processing companies around the world to implement food safety management systems which guarantees the production and distribution of safe foods. Prerequisite Programs (PRPs) are considered as the integral part of food safety standards and audit schemes all over the world. It is essential to implement food safety programmes in every company to check the chances of illness or injury due to unsafe food.

1. INTRODUCTION

Since vedic times, importance of fermented milk and its products was known but the major attention to probiotic and its health related benefits was gained after Eli Metchnikoff’s publication entitled “The prolongation of life” in 1908. Due to the awareness of the role of nutrition in health and well-being, improved knowledge of diet-related diseases, consumer demand for probiotic and prebiotic products has been increased in recent years. The link between diet and health is flourishing the market for health-embracing population and opens an opportunity for Food and Dairy Industries meet the demand of this market. Probiotics, constituting live micro organisms, have been incorporated into drinks, food products, supplements (tablets, capsules and freeze–dried preparations) and prebiotic products. Milk, milk based products, fruits and vegetables are rich in functional food components such as minerals, vitamins, dietary fibers, and antioxidants (phytochemicals). Application of probiotic bacteria in such products further enhances the nutritional value of the food product. Probiotic juices produced from fruits and vegetables have also been in consideration in recent years. The food market is being getting captured by pro- and prebiotic food products day-by-day. Even the agro-industrial by-products such as whey, wheat straw, rice straw, sugarcane bagasse, etc. are being explored for the economical and cost effective production of prebiotic molecules. Thus, this chapter gives a comprehensive overview of pro- and prebiotics and their market potential.

Introduction

Crop improvement lies at the heart of ensuring food security, agricultural sustainability, and the resilience of our farming systems. As we confront a world characterized by climate variability, emerging pests, and a growing global population, the need for innovative approaches to crop enhancement becomes paramount. This is where the concept of pre-breeding steps in: a fundamental phase that acts as a bridge between the untamed genetic diversity of wild plants and the refined traits of cultivated crops. Pre-breeding represents the exploration, identification, and incorporation of valuable genetic traits from the vast array of plant species that often remain on the fringes of agricultural attention. These “wild relatives” and underutilized varieties possess traits that have evolved over time to withstand diverse environmental stresses, combat diseases, and adapt to changing conditions. Pre-breeding aims to tap into these reservoirs of genetic potential, merging them with the qualities we value in our cultivated crops. At its core, pre-breeding is a scientific journey of discovery and innovation. It involves the strategic selection and hybridization of plant materials, guided by a vision of enhancing crop performance across multiple fronts. The goal is to create crop varieties that are not only productive and high yielding, but also equipped to thrive in the face of evolving challenges. This involves a delicate dance between tradition and cutting-edge techniques as well as collaboration between breeders, geneticists, and researchers (Qureshi et al. 2014).

Abstract

The concern of consumers for convenience and healthy foods involves many parameters like functional and nutraceutical properties, ease to prepare, good quality, economics as well as good nutritional profile of the food. This trend of convenience has been increasing in today's world because of the societal changes like the aging of population, the increasing entry of women into the labor force, the change to a multi-cultured society and the increasing polarization between poor and rich. Value addition to the traditional sources is a medium to bring variety products into the market. Cereal starches possess a wide application in the food industry as an additive but the native starch is not widely used in food industry due to its poor functional properties. Pregelatinized starches and flours have become important in processed foods because the functional properties of the starches and flours are improved over the native starches and cereal flours. Modification is a process which alters the structure of the starch in the wheat endosperm by affecting the hydrogen bonds in a controllable manner. Modification of starch and flours is generally done by several methods such as chemical degradation, physical alteration or enzymatic transformation. The primary objective of modification is to reduce the hot viscosity of the starch paste so that higher concentrations of starch can be dispersed without excessive thickening. The pregelatinized flours offer a tremendous number of functional benefits to variety of foods such as bakeries, snacks, beverages as well as nutritional foods. The various functional benefits of pre-gelatinized starch/flour as an additive are classified as fat replacer, texture improver, stabilizer, emulsifier, thickening agent and for freeze-thaw stability. Keywords: Pregelatinization, modification, functionality, cereal flour.

Introduction

Quality of fish is affected by various factors, which are classified into two categories: intrinsic factors and extrinsic factors. Intrinsic factors are the chemical and physical properties inherent to fish. Extrinsic factors are treatments given to fish before and after catch until it reaches the consumer, which includes the method of catch, cross contamination, processing, preservation, and product storage environment (temperature, humidity, packaging). The processing methods such as drying, smoking, chilling, and salting greatly help to minimize the spoilage. The quality of fish is also dependent on cold chain, in which the temperature is managed and monitored at every stage of production, transport, storage and sale.

2.1. Pre-Harvest Factors

Pre-harvest factors relates to the intrinsic factors affecting the quality of fish, as they are beyond the direct control of human. Various intrinsic factors affecting quality are fish species, size, sex, physiological state, parasites, naturally toxic fish, pollutants, and occasional peculiarities. Additionally, some of the extrinsic factors like method of catch and feeding interruption for starvation are also considered as pre-harvest factors affecting the quality of fish.

2.1.1. Species Characteristics

The quality of fish is related to species. For instance, flat fish keep better than round fish. Post-mortem pH varies between species. For example, long rigor period and low pH (5.4-5.6) of very large flatfish and halibut give relatively long iced storage life of 21 days, while mackerel with low post-mortem pH has no effect on shelf life. Some fish are rated as good quality as they are expensive, example, seer fish and pomfret. Fatty fish are rejected sensorial before lean fish due to the appearance of oxidative rancidity. So, lean fish keep longer than fatty fish under aerobic storage. Bony fish are edible longer than cartilaginous fish. Skin of fatty pelagic fish is very thin and contribute to faster

spoilage rate, as it allows enzymes and bacteria to penetrate more rapidly. Thick skin and slime of flatfish contribute for better keepability, as slime contains bacteriolytic enzymes, antibodies and other antibacterial substances.

Fruits represent a vital component of global agriculture, serving as not only a significant source of essential nutrients but also a lucrative sector of the economy. However, from the moment of their inception on the tree to their arrival on consumers’ tables, fruits undergo a complex journey influenced by a myriad of factors. Among these, pre-harvest practices wield a profound impact on fruit quality, enzymatic activities, texture, ripening, and ultimately, post-harvest transportation losses. Each pre-harvest practice, from mineral nutrition to harvesting methods, plays a distinct role in shaping the biochemical composition and physical attributes of fruits, ultimately affecting their marketability and shelf life. Mineral nutrition stands as one of the foundational pillars of fruit production, with essential minerals serving as building blocks for various biochemical processes. Irrigation practices represent another critical aspect of pre-harvest management, as water availability profoundly impacts fruit development and composition. Different irrigation regimes can influence enzymatic activities, fruit texture, and the timing of ripening, necessitating strategic water management to achieve desired fruit quality while minimizing post-harvest losses. Canopy regulation, achieved through training and pruning techniques, offers growers a means to manipulate light penetration and airflow within the orchard. Moreover, the application of plant growth regulators (PGRs) emerges as a tool for fine-tuning fruit development and ripening processes. By modulating hormonal signals, PGRs can alter enzymatic activities, influence fruit texture, and mitigate transportation losses. However, judicious application is paramount to avoid adverse effects on fruit quality and safety. Harvesting decisions, including the determination of optimal maturity and the timing and method of harvest, profoundly impact fruit quality and post-harvest losses.

Introduction

Introduction Woman dies as a result of the complications arising due to pregnancy such as sepsis, hemorrhage or obstructed labour. The possible reasons for high mortality and morbidity are the inadequacy of health services and ignorance regarding the need of obtaining medical care by pregnant or lactating women. ICDS has an important role to fill in this gap of knowledge and non-availing attitude of women. Integrated Child Development Services (ICDS) is a prominent national program that provides package of services of children and women. Role of Anganwadi worker in ICDS scheme has to provide information to beneficiary mothers regarding reproductive health, balanced diet, pre and post maternal services , neo-natal care and family planning etc .Group discussions are often organized to impart education regarding health, breast feeding and immunization etc at AWCs. AWWs also provide information to beneficiary mothers regarding health camp, doctor’s visit and immunization day by visiting the beneficiaries at home as well as at AWCs. Present research has focused on pre-maternal services. An assessment in the present study of the frequency of availing pre maternal services and the coverage of beneficiaries can give important information regarding actual benefits to the vulnerable groups.

Surgical Plan
i. Pre-operative Course of Action 
    a.    Client communication.
    b.    Clinical laboratory evaluation, radiograph, treatment for fluid or blood volume deficits. 

ii. Intra-operative Plan of Action 
    a.    Surgical approach 
    b.    Material and equipment needed 
    c.    Technical and support personnel

Pre-processing of fish

Fish is a highly perishable food which requires proper handling and preservation to increase its self life and retain its quality and nutritional aspects. Therefore, fish pre-processing and preservation are become a very important part of commercial fisheries. Preservation means keeping the fish after landing in a condition of wholesome and fit for human consumption for a particular period. This preservation should cover the entire period from the time of capture of fish to its sale at retailer’s counter. The main aim of processing and preservation of fish is to prevent fish from deterioration. Methods which are commonly used to preserve fish and fishery products include the control of temperature using ice, refrigeration or freezing and control of water activity by drying, salting, smoking or freeze-drying etc (FAO, 2011). Fish has to be pre-processed in such a manner that it remains fresh for a long time with a minimum loss of flavour, colour, taste, odour, nutritive value and digestibility. Fish processing can be subdivided into fish handling which is the preliminary processing of raw fish and the manufacture of fish products.

Introduction

Quality is very important in any production and operation system. It ensures whether the products produced or the services provided are of the right quality in right quantity at right time. Quality management must ensure proper quality of the product to survive in the market and expand its market. Quality of the product must be given importance to avoid quality failures that cause serious human inconveniences and wastage of money.

5.1. Definitions and Terminologies

5.1.1. Quality

We say a product is of satisfactory quality, if it satisfies the consumers. According to C. D. Lewis, a British writer, quality is “an asset which is offered to the potential customer of that product or service”. The International Organization for Standardization (ISO) has put up a more comprehensive definition of quality as “the degree to which a set of inherent characteristics fulfils requirements” (ISO 9000: 2005 – 3.1.1). In general terms, ‘quality’ is defined as the composite of characteristics that differentiate individual units of a product to determine its acceptability by the customer. Quality characteristics are nothing but elements that makes a product fit for use. Quality characteristics are further classified into categories called as parameters.

5.1.2. Total Quality Management

Total Quality Management (TQM) is an organization’s management approach, centered on quality. It improves the effectiveness and flexibility of a company or an organization. TQM is defined as “the system of establishing defect prevention actions and attitudes with a company or an organization on a permanent basis for the purpose of assuring conforming products or services directed at customer satisfaction”. TQM is based on the participation of all its members in decision making, which is aimed for long-term success, through customer satisfaction and benefits to the members of the company or organization and to the society.

The aim of pre-slaughter care of animals is to arrange physiologically normal animals for slaughtering without loss of weight and to minimize stress to the animals. Pre-slaughter care of meat animals includes proper handling of animals during loading, unloading, transportation, lairage care and handling of animals just prior to slaughter. Thus due care must be adopted in this stage not only for welfare point of view but also for production of good quality meat. Proper care and handling is also essential to reduce the chances of bruises, cuts, tears and deformities on the animals/birds body.

Pre-Treatment Before Sowing

The natural conditions necessary for seeds to germinate are increased by pre sowing seed treatment. Many plants and trees’ seeds require a specific amount of time to mature in their immature portions and to overcome dormancy, which is the absence of certain elements that impede germination, so that the seeds can sprout. Depending on the type of seed, different environmental factors promote different levels of germination. For example, some seeds need to be kept in a very damp, cold environment, while others need to be kept in a dry, hot environment. Different techniques are employed to support seed survival and speed up germination, depending on the size of the lot, the species, the local conditions, and the availability of pertinent tools and facilities. Many species’ seeds don’t germinate successfully unless they are exposed to specific circumstances. Dormancy is the state in which seeds do not germinate unless certain circumstances are met. Conditions in the natural world could include being near fire or being eaten by animals.