eChapters

ABSTRACT

This paper provides an account on the origin of the concepts of IP, gradual development and their culmination at the TRIPS.

Introduction

Intellectual property rights form the most prominent and ever-expanding category of rights in the 21^st Century. It differs from other proprietary rights in many respects and prevails in most articles of law, which influence our daily life. The economic significance of intellectual property rights has made it a subject of global political interest. In the broader sense, the term “intellectual property rights” connotes different categories of rights such as patents, copyrights, trademarks, designs, plant varieties, semiconductors, geographical indications, trade secrets and data exclusivity with varying scope

Agriculture, also known as farming, is the production of food, fiber, animal feed, and other goods by means of growing and harvesting plants and animals. Agriculture is practiced throughout the world. Many agricultural products are used every day, from the clothes we put on in the morning to the sheets we sleep under at night. When you think of agriculture, think of the five F’s: food, fabric, forestry, farming, and flowers.

Agriculture is the science, art and industry of managing the growth of plants and animals to make use by human beings. In general, agriculture includes soil cultivation, growing and harvesting field crops, raising and breeding livestock, dairy and forest trees etc. The word agriculture is the English adaptation of Latin word i.e. agricultura, from ager, “a field” and cultura, “cultivation” in the strict sense of “tillage of the soil”. Thus, a literal reading of the word yields “tillage of a field/ fields”.

Abstract

This chapter provides a brief overview of the key milestones in the development of bioinformatics that would help to understand the historical context and evolution of a subject. As an interdisciplinary field, bioinformatics has grown gradually from molecular biology, with the development of various algorithms, databases, and other important tools that have helped to advance computational biology. Some important events in the history of bioinformatics might include the development of the first algorithms for sequence alignment and comparison, the creation of early databases such as GenBank and Swiss- Prot, and the development of software tools for molecular modeling and drug design. Other key milestones might include the sequencing of the first genomes, the development of high-throughput sequencing technologies, and the emergence of new areas of research such as systems biology and synthetic biology. By understanding the historical context of bioinformatics, students and researchers can gain a deeper appreciation for the current state of the field and the ongoing efforts to advance our understanding of the molecular mechanisms that underlie life.

1.1 Introduction
The concept of invention is the fundamental requirement for design thinking. Since the birth of mankind, people started inventing many concepts, which are mainly observations of facts and innovation of ideas for producing products that are useful to the society. The design thinking requires unconventional thinking to design processes for maximal operational efficiency of manufacturing the products, which give maximum satisfaction to customers with more value for money. Hence, the team that is involved in the design thinking projects may gain the required skills by knowing several inventions of the past. Hence, a review of inventions is presented in this chapter.
1.2 Tracing Inventions
The content at https://www.explainthatstuff.com/timeline.html gives a complete account of inventions starting from 4–5 billion years ago up to 2022. The article on solar cell energy gives an account of the sun started producing energy. About 1.2 million years ago, humans invented fire, which has been further innovated for biofuels, candles, IC engines, aviation engines, etc. In the 7th century B.C., ants were killed by burning in the heat produced by concentrated sun rays using magnifying lens. Greeks and Romans utilised burning mirrors to light candles during religious ceremonies in the third century B.C. About 3.5 million years ago, stone, wood, antlers, and bones were used by humans to make first kind of tools. These were further improved to make tools for machines. About 4000 BCE back, iron was used to make decorative ornaments. About 3500 BCE, people invented the concept of wheel, which brought quantum revolution in transportation.

Abstract

The knowledge of programming language(s) is necessary to solve biocomputational problems and also understand the data pattern. Computer programming is used to develop software to extract information from data which is very crucial while practicing bioinformatics. Programming language is a man-made, computer-understandable, artificial language, that is designed to instruct a machine, particularly a computer to get the desired output. This chapter briefly narrates the concept of algorithms, programming languages, and the historical perspective of the same.

Nowhere in the plant kingdom do ecology, evolution, and human affairs come together as intricately as phenomena involving secondary metabolites. The importance of these compounds is apparent in some of the earliest annals of human history. For example, Papaver somniferum, the original source of morphine and codeine, was known to the Sumerians in 4000 B.C. as hul gil (joy-plant). These two alkaloids, so important in human affairs for many years, probably evolved within the genus Papaver originally as protective compounds against herbivores. As a testament to the importance of secondary metabolites,

P. somniferum was one the first plants to be cultivated for a reason other than its caloric or nutritive value. Sadly, its importance has only increased over the time. Organic chemists of the nineteenth century were among the first to recognize and study the diversity of plant secondary metabolites and to analyze them both in terms of structure and function. The German organic chemists developed techniques to acetylate morphine and produce what they claimed at the time to be a non addictive version of the drug. However, acetylation product of morphine trade name Heroin, was vastly more addictive. The economies of several developing nations in Asia still depend on the acetylation of this plant secondary metabolite, and tens of thousands of lives each year are destroyed by its commercial importance. In another striking example of profitable secondary metabolites, acetylation techniques to salicylic acid, derived originally from the bark of willows, Salix, to create aspirin. The modern appreciation of these secondary metabolites from ecological and evolutionary perspectives had its spread outside of the plant-insect ecology community. The overwhelming array of chemicals found in plants was more than simply by-products of primary metabolism that served as waste products for these organisms that lacked excretory systems.

Ecologists and evolutionary biologists soon took up the cudgels, and the past 60 years have seen the development, testing, refinement, and, in some cases, rejection of models that describe the ecology and evolution of these “secondary” substances. With the functional roles of these compounds broadly acknowledged, several challenges presented themselves to scientists interested in their ecological and evolutionary dynamics. Most obviously, the details of the processes underlying the interactions between each of these compounds and their target pest or pathogen became one of the most vibrant topics in ecological and physiological research.

Abstract

When only sequence data is available, homology modeling has become a useful tool for predicting protein structure. Protein structure is often more important than sequence data when evaluating protein function. Homology modeling, also known as comparative modeling, is based on the principle that two sequences that exhibit a high degree of identity or similarity will also share similar structures. This chapter explores the steps involved in homology modeling, including template selection, alignment, model building, refinement, and validation. The Ramachandran plot is a valuable tool for assessing the conformation and bond angles in a protein model, and we discuss its significance in the context of homology modeling. Ultimately, homology modeling is an effective method for predicting protein structure and has numerous applications in protein engineering, drug discovery, and other fields.

Introduction

In the perspective of the accelerating national growth rate of 8% recorded at the end of the 10th Plan to a projected growth rate of 10% by the end of the 11th Plan, yielding an average GDP growth rate of about 9% it was appearing that the nation is going to have a strong footing of development. However, it could not be fully achieved due to several reasons including the global recession and other factors related to international economic setback which may deter achieving a projected growth rate of 10% in the 12th Plan. In consideration of the international scenario of growing complicacy in economic growth more emphasis should be given on further efficient utilization of natural resources and intellectual properties of grass root innovators to improve per capita income leading to a promising national structure of economics ensuring wide spread benefits to the society. In this regard, true development of a nation like India can be primarily realized by recognition of wide spread enthusiasm of its innovative human resources living in village and rural areas. It can be made possible only through working with them by appreciating their struggle for survival using all round innovative measures coming out of their daily life experiences and traditional knowledge. Technopreneur Promotion Programme (TePP) is a unique scheme of Government of India for development of society especially by promoting the intellectual properties of grass- root level innovators coming out from the society with a source of inspiration arising out of their daily life struggle for existence. In spite of its limited publicity in remote areas an awareness of this programme has often been found to raise great hope to the villagers to do something for their society exploring the ideas generated from the experiences of life with the help of local resources. Such naturally grown innovation can be found undoubtedly novel and the idea can change their world of dreaming for a more prosperous life by bringing changes in socioeconomic pattern of trade and employment in rural areas with proper support from Government if India through the scheme like TePP.

Hormones are a group of biochemical messengers that assist in transmitting signals from one part of an organism to another. The term “hormone” was first coined by Ernest Starling in 1905 after the discovery of secretin, a chemical produced in the small intestine that regulates pancreatic secretions. In 1937 Went and Thimann defined hormones as “a substance which, produced in any one part of an organism, is transferred to another part and there influences a specific physiological process”. Since then hormones are also known as chemical messengers. These intercellular messengers are produced by specialized cells of endocrine glands, generally called effectors and released into the bloodstream thereby assisting in the regulation of physiological processes in target cells. Hormones assist in the regulation of a plethora of cell functions such as maintaining homeostasis, metabolism of biomolecules, growth, and reproductive function, and controlling blood pressure and glucose levels that are essential in orchestrating an intricate body- balance. The pituitary, thyroid, pancreas, adrenal, parathyroid, and gonads (testis and ovary in males and females respectively) produce hormones. Apart from these endocrine glands, few other organs such as the kidney, heart, and liver are also involved in hormone production. The pituitary gland

Abstract

Thermophiles mainly harbor in highly temperate environments such as hydrothermal vents, hot springs, fumaroles etc. The main importance of thermophiles is due to their thermostable proteins, enzymes and their adaptive mechanisms at higher temperature which are very useful for industrial applications. The main rationale behind this research was to isolate industrially important thermophilic bacteria from the Hot Springs of Sikkim which can be used as tools for genetic engineering and vector based research activities.

Hybrids are produced by crossing two genetically diverse parents variety. Hybrid vigour is at its maximum in the F₁ generation and hence highest emphasis is placed on the F₁ hybrids. Hybrid varieties leads to maximum exploition of heterosis as compared to any other varieties. Beal in 1880 recommended the use of F₁ varietal crosses of maize for commercial cultivation.

Mangelsdorf (1951) has opined that hybrid corn has been the most far-reaching development in applied biology. Hybrid cultivars have contributed enormously to world’s food and feed resources. Although dramatically successful at first in corn, hybrids have spread to several other crops both in cross-pollinated and self-pollinated species. Their use is likely to spread more in time to come. Hybrid varieties are those in which F1 populations are used to produce commercial crop. Parents of F1 may be inbred lines, clones, varieties, or other populations. Hybrid breeding is historically rooted in development of hybrids in corn and therefore most of the issues covered in this section relate to hybrid breeding in maize.

The term hybrid or hybrid variety is used to designate F1 populations that are used for commercial plantings. Such F1 populations are obtained by crossing clones, open-pollinated varieties, and inbred lines that are genetically dissimilar. Historically the first attempts to make practical use of fortunate mating system of maize came late in the nineteenth century by W. J. Beal in Michigan, stimulated by Darwin’s work on inbreeding and outcrossing. Beal suggested use of F1 varietal crosses to exploit heterosis for commercial crop. The hybrid seed was to be produced by detasseling alternate rows. It was George Harrison Shull (1909) who first suggested a pure line method of corn breeding based on inbred lines obtained by continued self-fertilization and the use of F1 hybrids between these inbred lines for the production of commercial crop. His proposal was to make use of single crosses (hybrids between two inbred lines) based on the superior performance of the hybrids in various combinations between the inbred lines.

Hybrid vigour in plants has long been noted, and the first suggestion that it be exploited in vegetables was by Hayes and Jones in 1916. F1 hybrid eggplants were used on commercial scale in Japan before 1925. Demonstration of the value of hybrids in corn in the early 1920’s gave impetus to a few exploratory studies in other crops. Methods of its application to large scale field production of hybrids in vegetable crops were first proposed in 1932 using the self incompatibility system in cabbage and in 1943 using the cytoplasmic genetic male sterility system in onion. Today hybrid varieties are common in several vegetable crops viz., sweet corn, onion, tomato, summer squash, ordinary cabbage, cucumber, watermelon, muskmelon, asparagus, sweet pepper, chilli pepper, spinach, broccoli, Chinese cabbage, eggplant, Brussels sprout, Chinese radish, red beet, celery, bottle gourd, bitter gourd, okra, etc. India figures prominently in commercial exploitation of heterosis in vegetable crops like cabbage, tomato, okra, watermelon, muskmelon, eggplant, bottle gourd, bitter gourd and cucumber.

Floral Biology and Crossing

Pearl millet spikelets bear 2 types of florets, one being bisexual and the other staminate. A singIe pistil with 2 feathery and 3  anthers is enclosed between the lemma and palea. The unisexual staminate florets are sessile and borne below the bisexual flowers. These have 3 anthers and lack the female organs. Pearl millet is a highly protogynous species and thus  highly cross pollinated.
 
The time of panicle exertion from boot leaf varies in inbreds and hybrids. Bhatnagar and Kumar (1960) observed that spike takes 6 days to emerge from the sheath with the maximum emergence on the fourth or fifth day. The stylar branches protrude first from the florets at the tip of the head and gradually proceed downwards. Most of the stylar branches on the earheads emerge by the third day. There exists a great variation in the time taken for the complete emergence of the styles in the hybrids than in the inbred lines (Tewari et al.,1971). Anthesis in pearl millet is completed in two phases. The first involves the bisexual florets while the second involves staminate florets. It has been generally observed that the anthers in the sessile male florets emerge 2-3 days after the anthers have emerged in the bisexual florets. Thus most heads continue to shed pollen for 4-6 days.The largest number of anthers emerged between 8 PM and 2 AM. Environmental factors like temperature and humidity have significant role in the anther emergence.

Hybrid Rice

People’s Republic of China announced the successful development and use of F1 rice hybrids in the late 1970s. The first hybrid rice combinations were put into commercial production in China in 1976. Since then commercial exploitation of hybrid rice attracted the attention of researchers around the world. It is accepted that about 20% yield advantage of hybrid rice would be usually required to meet the extra cost of seed production and the future rice demands of a growing world population. Realizing the prospects of hybrid rice, IRRI intensified research on this and organized an ‘International Symposium on Hybrid Rice’ on 6-10 October 1986 at the Hunan Hybrid Rice Research Centre, Changsha, China where Prof. Yuan Longping and his co-workers had made their names in development of hybrid rice. The proceedings were brought out in form of a book entitled ‘Hybrid Rice’ in 1988 by International Rice Research Institute, Philippines. This book documents the information exchanged, and presents for the first time, in English, much of the Chinese literature on hybrid rice.

Squashes and pumpkins are vegetable crops of the genus Cucurbita. They are grown in temperate, subtropical and tropical regions of the world. These crops are common elements in home gardening and subsistence agro-ecosystems in most countries and are produced on commercial scale in some countries. The economic botany, genetics and evolutionary history of Cucurbita has been reviewed by Whitaker and Davis (1962) and Whitaker (1974).

The mating or crossing between two genetically dissimilar plants or lines is known as hybridization. In other words, hybridization is an artificial controlled pollination in which pollen grains of desired male parent is transferred on the stigma of the desired female parent.

Objectives of Hybridization

To create genetic variability, which is pre-requisite for crop improvement programme.

To transfer one or more characters into single plant.

To know the inheritance of the characters.

To estimate the general combining ability of the parents and specific combining ability of the crosses.

To exploit and utilize the hybrid vigour.

To produce hybrid/synthetic varieties.

Agriculture nowadays is facing a complex problem. It’s the rate at which we are turning arable land into non-arable. To solve this problem, we cannot simply stop farming and wait for the Earth to return to its natural state. Hence, alternative farming methods have become increasingly popular in recent years. Hydroponics is one of these options that can help produce crops without soil and other resources needed for crops to grow.

2.1 Definitions

Hydroponics is the term for growing plants without soil and in a water-based solution, the roots may be physically supported by an inert medium such as perlite, gravel, or other substrates. While it can be used to grow all kinds of crops, hydroponics is particularly effective for growing leafy vegetables, herbs and salad greens that have high water requirements, as well as for growing plants that have very shallow root systems.