eChapters

History

Pauling and his colleagues coined the phrase "molecular disease" in 1949, based on their finding that a single amino acid shift in the β-globin chain causes sickle cell anemia, which is characterized primarily by repeated bouts of acute pain due to vessel occlusion. In theory, their discoveries laid the groundwork for molecular diagnoses, though the major breakthrough came many years later. At the time, when molecular biology was only rapidly growing, providing molecular diagnostic services was unthinkable and practically impossible. In the early days of recombinant DNA technology, many scientists from different f ields collaborated to provide the first seedlings of molecular diagnostics.

Introduction

Nanoparticles are minute particles with at least one dimension that measures less than 100 nanometers. They have been extensively studied in various f ields including medicine, biology, chemistry, physics, engineering, and environmental science. Nanoparticles have several unique properties, such as a high surface area to volume ratio, enhanced reactivity, and optical, electrical, and magnetic properties that differ from the bulk material. These properties make nanoparticles suitable for a variety of biomedical applications, including diagnosis, imaging, drug delivery, and therapy. This chapter will discuss the current and potential applications of nanoparticles in healthcare and research.

Cowpathy

Panchgavya chikitsa is an age old system of medicine described in ancient Indian literature ‘Ayurveda’ and now it is known as ‘cowpathy’ means the therapy of human ailments through cow products. However, Cowpathy is different from Panchgavya as it also include cow cuddling, Backrub, Gau grass, Gauseva, and living with cow besides, Panchgavya products milk, curd, ghee, urine and dung. Since the cowpathy practice is to increase the aura of an individual, it prevents from many ailments and infections. In Ayurvedic system, the medicines are prepared either from plants or from animals besides the use of certain metals. The Ayurvedic medicines of animal origin are mainly prepared from indigenous cow products such as urine, dung, milk, curd and ghee. Medicinal use of cow urine has been in practice since time immemorial in India.

Introduction

However, most of the crops get damaged by pest infestation, microbial attacks, and insufficient nutrient availability. Currently, the primary goal of world’s agriculture is to fulfil the nutritional demand of the rapidly growing population. Nanotechnology tries to fill the gaps in agriculture to become more resilient, while making sure there is enough food for everyone. As a result, nanoparticles are evolving into a cutting-edge material that will change how contemporary agriculture is done. The use of nanotechnology in agriculture encompasses the creation of novel materials, devices, and systems at the nanoscale to enhance the efficiency, productivity, and sustainability of agriculture. This technology has the potential to bring a revolutionary change to the field of agriculture by offering innovative solutions to various agricultural problems.

Introduction

Nanocomposites are materials that incorporate nanosized particles into a standard material matrix. The addition of nanoparticles can significantly improve properties such as mechanical strength, toughness, electrical or thermal conductivity. Typically, only a small amount of material (0.5-5% by weight) is required due to the effectiveness of the nanoparticles. A nanocomposite is a solid material that consists of multiple phases, where at least one of the phases has one, two, or three dimensions in the nanometer size range. The goal of the nanoscale phase process is to achieve synergy between different constituents. Nanocomposites represent a promising alternative to overcome current limitations of microcomposites and monolithics, and are becoming the materials of the future (Schmidt et al., 2002).

Introduction

The term "nano" is used to define one that has a size in the nanometer range. Nanotechnology is an interdisciplinary field of medicine, chemistry, physics, and biology that has emerged during the past few decades as a potential area of study. The goal of this interdisciplinary technology is to transform molecules into entities, then do the opposite. Nanobiotechnology is the term for the fusion of nanotechnology with biotechnology. In nanobiotechnology nanoscale principles and techniques are used to explore biosystems and generate novel biomaterials. Biosensing, cell labelling, and molecular imaging can all gain benefit from nanostructure materials in life science, health and biomedicine.

Introduction

Non-coding RNAs (ncRNAs) are RNA molecules that do not code for proteins. They are transcribed from DNA and can be categorized into two main types: long non-coding RNAs (lncRNAs) and small non-coding RNAs (sncRNAs). While sncRNAs are shorter than 200 nucleotides, lncRNAs are usually longer than 200 nucleotides. Non-coding RNAs have been found to play important roles in a variety of cellular processes, including gene expression, cell differentiation, and development.

Introduction

Currently, the agricultural industry is expanding exponentially. Improved economic growth and rapid population growth have spurred investor interest in the agricultural industry. The World Bank estimates it to be worth $3 trillion. With the urbanization and industrialization of the agricultural sector, the amount of waste generated has also increased, causing many environmental problems. About 5 million metric tons of biomass are produced annually from agriculture. These agricultural wastes become breeding grounds for pathogenic microorganisms if not properly treated and recycled, it is noteworthy that this agricultural waste can be used as substrates for the synthesis of valuable product or as raw material for renewable energy production.

Introduction

Wheat, a vital cereal crop cultivated globally, serves as a fundamental source of sustenance and livelihood for millions (FAOSTAT, 2021). However, wheat production faces hindrances from various biotic and abiotic stresses, with heat stress being a notable challenge (Prasad et al., 2019). The term “terminal heat stress” refers to the elevated temperatures occurring during the crucial reproductive phase of wheat, encompassing the grain-filling period and flowering stages (Lobell et al., 2012). Terminal heat stress emerges as a significant impediment to wheat cultivation, particularly in arid and semi arid regions, manifesting during the reproductive stage of the crop (Wassmann et al., 2009). This predicament is exacerbated by the escalating frequency and intensity of heat waves attributable to climate change (IPCC, 2021).

Introduction

Recognizing the importance and impact initiatives were taken for starting National Horticulture Mission, announced by Honorable Prime Minister on 15 August 2003. Crop diversification has become an imperative for India’s agri-economy. To address this need and to give further impetus to encouraging growth in cultivation of horticultures, vegetables, flowers, species etc. a National Horticultural Mission has been launched. Its main target will be doubling India;s horticultural production by 2010. Sub sequentially, National Horticuture Mission was launched during Tenth Plan with effect from 2005 2006 for holistic development of horticultural crops, having competitive advantages.

“Curriculum” is seen often as a critical issue during discussions on quality of agricultural education, being considered variously as content, as product and as process. It is easy to make the assumption that a common understanding of curriculum, but in practice this is far from the case, with a host of definitions, approaches and ideological standpoints. Even though a dialogue on curriculum theory is well established, there is still a strong tendency in practice to understand curriculum as a list of content, often developed in considerable detail, that students should be taught.

Curriculum reorientation is necessary, when any one in use is no longer responsive to the needs, interests and unable to meet the demands of the farming community to which it is intended to serve. In any case a number of factors, such as those listed below, must be taken into consideration while reorientation:

There should be an analytical assessment of the existing agricultural extension curriculum in order to justify any proposed reorientation.

Learning needs of the farm university graduates and farmers should be reviewed from the point of view of both individual learner requirements and national development needs.

To explain the main concepts and elements of a participatory curriculum development process

To present practical skills and knowledge leading to the effective design of teaching and learning

To build confidence of the learners in applying new methods and approaches to teaching and field extension work.

To demonstrate application of participatory approach in development of Extension curriculum

This Toolkit emphasizes an active learning approach, based on the process of experience, reflection and action. The key principle is that people do not learn simply by passive listening. They need to be involved from beginning of the training and designing of the program.

Real benefits are obtained when we use a participatory approach to curriculum development and reorientation. Primarily, the course contents we provide and the learning will become more effective. If students participate actively in the learning process, then they are more likely to learn and teaching is more likely to be effective. They will have more ownership in the teaching, because their needs will have been identified and hopefully they will also be involved in deciding how their needs can be met. This will increase their motivation, which will help them to learn more effectively.

While developing the toolkit for Participatory Curriculum Development participatory approaches like Focus Group Discussions and Field Level Workshops were adopted. The goal is to provide demand-driven services and to do so, extension professionals need to respond for farmers’ requests rather than deliver predetermined packaged solutions. It is also time to enable the farmers to empower and make their voices heard. Equally important is to make the service providers accountable to the farmers, which is possible when the farmers pay for the services they receive.

To address the present day problems in agriculture and horticultural sectors and also to equip the graduating and postgraduate agricultural students, the ICAR has been continuously striving to bring necessary reforms for quality enhancement in agricultural education. The Council has appointed National Core Group and BSMA Committee for revision and restructuring of Post graduate and Doctoral syllabi in consultation with all the stakeholders to meet the challenges and harness opportunities in various disciplines of agriculture and allied sciences. It has been felt that a paradigm shift is necessary in academic regulations to comply with various provisions of National Education Policy-2020. The syllabus of Masters’ and Doctoral programs was restructured and new courses were introduced.

Participatory curriculum reorientation awareness-raising workshop for key stakeholders: In the present study focus group discussion and workshops were conducted to know the effectiveness of present curriculum of extension education with different stakeholders (Students UG, PG and Ph.D, Extension teachers, Field extension workers and farmers). Data were collected by using schedules regarding the important contents of present curriculum and most important for extension workers in the present situation to be included in curriculum

Identify main reasons and purpose of curriculum development and key areas needed by stakeholders for curriculum change. This can be done by adopting participatory methods like Focus group discussion/ field level workshops. Carry out stakeholder analysis and identify specific potential areas suggested by stakeholders to be included in the curriculum for better performance at the f ield level and their likely role in the process. In order to encourage greater stakeholder involvement invite stakeholders such as staff and students from various farm universities, field extension workers and farmers.

The recent concept of intellectual property emerged in England in the 17^th & 18^th centuries. The term Intellectual Property came in use in the 19^th century and in the late 20^th century. As of now the Intellectual Property has occupied common position in the global legal systems. There are different forms of Intellectual property rights which include patents, copyright, industrial design, trademarks, plant variety rights, trade dress, geographical indications and in some jurisdictions trade secrets too

Major International Treaties Related to IPR & TRIPS

There are different forms of intellectual property like Patents, Copyright, Trademarks, Industrial design, Plant Varieties etc. Various meeting and conventions were also convened for the protection in these intellectual properties at international level from time to time and to bring uniformity and coordination among member countries. These were reflected in different treaties, which are mentioned below. Among all these treaties/conventions the agreement on Trade related aspects of intellectual property rights (TRIPS), which runs under aegis of World Trade Organization is most influential, comprehensive and inclusive of all.