eChapters

Fracture healing is a complex process in which damaged bone restores its original architecture through a cascade of molecular and cellular events. The process of fracture healing is unique, in that it does not form a poorly organized replacement matrix, otherwise known as scar tissue, but rather regenerates the original matrix and retains its mechanical properties. Normal fracture and bone repair follows a known sequence of events includes: haematoma formation, inflammation, angiogenesis, osteogenesis, and bone remodeling.

For the repair of bone defects, a tissue engineering approach would be to combine cells capable of osteogenic (i.e. bone-forming) activity with an appropriate scaffolding material to stimulate bone regeneration and repair. An ideal tissue-engineered bone substitute should possess 3 elements: osteoprogenitor cells, osteoinductive factors, and an osteoconductive scaffold, and is considered as a potential substitute for autologous bone transplantation. Tissue engineering approaches have proven very effective in bone regeneration recently, and the successful repair of bone defects has been demonstrated in larger animals like canine, goat and sheep.

Stem cells from adult tissues are attractive materials for cell therapy, gene therapy, and tissue engineering. These cells generally have restricted lineage potential when compared to embryonic stem cells, and this may be advantageous in certain therapeutic applications. Till and McCulloch in 1961 describes the presence of hematopoietic progenitor cells in bone marrow. After this, the concept of MSCs is brought to light by Friedenstein and co-workers who demonstrated the osteogenic potential of BM cells by heterotrophic transplantation.

The most important use of R programming lies in importing of data files which serves as input for the analysis work. After the analysis is over by using R codes, operators and functions, the output result must also be exported in form of files. The files are imported in form of csv files (comma separated variable), text files or excel files.

Before going to the actual content of the chapter we have to have an idea about csv files. CSV stands for Comma Separated value. It is used to store tabular data, such as a spreadsheet or database. CSV is delimited text file in which the values are separated by commas. CSV files occupy much less space than excel files and also gets imported in a program at a much faster rate than Excel files. CSV Files also does not manipulate data and stores as it is.

Let us consider that an excel file named as ‘plant’ which stores three variables, named as ph, pd and yield is created inside the folder named as ‘My Data’ which is placed in the desktop. Thus the path of the file is “C:\\Desktop\\My Data\\plant”

To import excel file the package will be readxl and the command will be library(readxl)

Real benefits are obtained when we use a participatory approach to curriculum development and reorientation. Primarily, the course contents we provide and the learning will become more effective. If students participate actively in the learning process, then they are more likely to learn and teaching is more likely to be effective. They will have more ownership in the teaching, because their needs will have been identified and hopefully they will also be involved in deciding how their needs can be met. This will increase their motivation, which will help them to learn more effectively.

Incentives are a powerful stimulus to transfer of technology. They can encourage researchers to get their results to market, a new career path for many of them. They can create a culture that attracts and retains entrepreneurial staff, scientists, students and technology transfer professionals (TTPs) that view the university as a career path and a vehicle for making a contribution to society. Working in a pro-entrepreneurship team of colleagues can also lead to getting people to think in terms of making a connection between their work and its application. Incentives can be short-term or long-term in nature, and can be tailored to individual or collective requirements. As it is likely to be challenging for universities to design incentives that cater to every researcher’s or TTP’s desire, they can design incentive programs to cater to various aspects of human. Nature.
12.1 Why incentives matter in this ecosystem
Incentives can be either financial and non-financial. These are needed to ensure that researchers and TTPs remain motivated, aligned with institutional goals, and committed to the long-term process of technology transfer and commercialization. Incentive programs serve several important purposes:
• Motivation: Incentives energize individuals to pursue innovation and commercialization, often over long- and uncertain-time horizons.
• Retention: By offering recognition, rewards, and career advancement opportunities, institutions can retain high-performing researchers and skilled TTPs.
• Alignment: Well-designed incentives ensure that the personal goals of stakeholders align with institutional and societal objectives.

8.1 Learning Objectives
After completing this chapter, you should be able to:
i) Understand the concept and significance of index numbers;
ii) Identify different construction methods;
iii) Understand the importance of selecting appropriate base and current periods;
iv) Recognize the properties and tests of adequacy;
v) Recognize the challenges and limitations of index numbers;
vi) Stay informed of recent advances;
vii) Synthesize practical examples and calculations for creating index numbers.

8.2 Introduction

In this chapter, we embark on a journey through the intricate world of index numbers, a cornerstone in the realm of statistics. We will explore what index numbers are; their various types; and the methodologies employed in their construction. Delving into real-world applications, we’ll uncover how these numerical tools are pivotal in measuring economic trends, informing policy decisions, and shaping our understanding of complex data sets. By the chapter’s end, you’ll gain insights into not only the mechanics but also the profound impact of index numbers in our data-driven society.

An index number is a statistical measure designed to show changes in a variable or group of related variables with respect to time, geographical location or other characteristics like: income, profession, etc. A collection of index numbers for different years, months, locations, etc. is called an index series. Since index number are usually used to measure the level of business and economic activities over a period of time, so they are rightly called barometers of economic activities or simple called economic barometers. The various problems faced in the construction of an index number are to known the specific purpose of index number, selection of items, data for index numbers, choice of base periods, choice of an average, selection of weights and choice of a suitable formula.

Methods of Constructing Index Numbers

A number of formulae have been developed for constructing index numbers, which may be grouped into the following categories:

• Unweighted index numbers

• Weighted index numbers

• Unweighted index numbers: In this case, weights are not expressly assigned. 

Abstract

The main aim of the article is to identify the strengths, weaknesses, opportunities and threats of current IPR system in context to Indian regime and also to understand overall planning as well as important tactics and means to use IP legal protection system to fully safeguard one’s legitimate rights and interests, obtain and maintain competitive edges, restrain competitors and seek optimal economic performance by selection of appropriate IP strategies. This article also proposes ways to select IP strategy based on BCG matrix and product mix.

The history of Patent law in India starts from 1911 when the Indian Patents and Designs Act, 1911 was enacted. The present Patents Act, 1970 came into force in the year 1972, amending and consolidating the existing law relating to Patents in India. The Patents Act, 1970 was again amended by the Patents (Amendment) Act, 2005, wherein product patent was extended to all fields of technology including food, drugs, chemicals and micro organisms. After the amendment, the provisions relating to Exclusive Marketing Rights (EMRs) have been repealed, and a provision for enabling grant of compulsory license has been introduced.

Dairy farming has been the backbone of the agriculture and rearing of livestock for milk/milk products and draft power has been the tradition of ancient rural India. Whenever the crops have failed miserably attributed to natural calamities, the livestock has emerged the savior of farmers providing livelihood security in rural India. India is a country of villages (640930 villages) and 68.84% population of India is living in villages as per the All India Census, 2011. Further, 41.8% rural population is below poverty line as compared to 25.7% urban population (Basic Animal Husbandry Statistics, 2012). The marginal and small farmers are rearing 71.7% of total livestock revealing that livestock has been the source of sustainable livelihood security for rural poor majority of which falling under the category of population below poverty line.

I. INTRODUCTION

Information technology has heralded a new era of Communication System. It has revolutionized the whole commercial world. The mother earth looks like a global village where people sitting thousands of miles away can talk face to face, like people sitting across the table. Business men and consumers are using computer to create, transmit and store information in the electronic form. Traditional form of paper documents are being discarded for the reason that electronic method is Cheaper, easier to store, retrieve and communicate. Though these advantages are obvious but people were reluctant to transact business in electronic form due to lack of legal frame work, validating these transactions. All the paper transactions involved writing and signature to conclude them. These writings and signatures posed a great hurdle for electronic governance and electronic commerce for validating and enforcing them. The law of Evidence is based on paper made documents which should have been signature. Since electronic commerce eliminates the need for paper based transactions, hence to facilitate e-commerce the need for legal change has become an urgent necessity. International trade, though the medium of e-commerce, is growing by leaps and bounds for the past few years. Many countries have switched over from traditional paper based commerce to e-commerce. The instantaneous means of communications through internet have been a great menace to copy right in different areas David Teather from London has reported that the International Federation of the Phonographic Industry say that the market in year 2000 was worth $36.9 billion, a fall of 1.3 per cent on the previous year. The biggest decline in the sale of C.D. singles was 39% and globally it fell by 14%. The growth in popularity of Napster and to contain the damage. Napster is in the process of removing copyrighted material from its site.¹ But the powers of the computer are so great that the law enforcement agencies are facing a real challenge to contain its onslaught. Internet telephony is a common sight at cyber cafe, despite the fact that it is illegal.2 B.B. Nanda and R.K.Tewari observe that “ internet paedophilia, computer network break-ins, industrial espionage, Child pornography password sniffling, spoofling, telecommunications fraud, software piracy, e- mail bombing and spamming, and the availability of illicit or unlicensed products and services are offences already making themselves felt. Emerging problems include credit card fraud, cyber terrorism, cyber laundering and criminal use of secure internet communications. The huge growth of internet will breed cyber fraud with great ease especially in the area of share-holdings of companies.3 The present weak electronic system of payment without adequate safeguard is posing a serious risk for unauthorised withdrawals from banks and counter money laundering operations. Software piracy is a boom business and video and phonographic industries are sinking day by day globally.4 The UNCITRAL Model law provides for equal legal treatment of users of electronic communication and paper based communication. In pursuance of a declaration made ‘by Member Countries, the World Trade Organisation (WTO) is about to form a work programme to handle its work in this area including the formation of multilateral trade deals through the medium of electronic commerce. The paper discusses, briefly, the meaning of cyber space the origin and development of intemet and e commerce its uses and abuses. Certain provisions relating to Information Technology Act, 2000 have been briefly discussed to apprise oneself about its effectiveness in meeting the challenges posed by e commerce in different areas.

VIVEK M. PATIL

The term “information” has a diversity of meanings, from everyday usage to technical interpretations. Generally speaking, the concept of information is associated with knowledge derived from study, experience, or instruction. Technology, on the other hand, refers to the application of knowledge to the practical aims of human life, or to changing and manipulating the human environment. Technology includes the use of materials, tools, techniques and sources of power to make life easier or more pleasant and work more productive. Technology began to influence human endeavour as soon as people began using tools. Technology also started being used for managing information when the amount and variety of information grew to such vast proportions that the human brain could neither store nor process it efficiently.

Definition

The term Information Technology (IT) was coined by Jim Domsic of Michigan in November 1981. Domsic created the term to modernize the outdated phrase “data processing”. Information Technology is a general term that describes any technology that helps to produce, manipulate, store, communicate and/or disseminate information. Presumably, when speaking of Information Technology as a whole, it is noted that the use of computers and information are associated. “Information Technology” as defined by the Information Technology Association of America (ITAA), is “the study, design, development, implementation, support or management of computer-based information systems, particularly software applications and computer hardware.” IT deals with the use of computers and computer software to convert, store, protect, process, transmit and securely retrieve information.

India is bestowed with a wide variety of livestock species which forms the backbone of the economy of majority of the farmers. Cattle are one of the important species domesticated by man mainly for their draftability in agricultural operations. Rearing of cattle is an integral part of the Indian agriculture as it is always considered as a subsidiary enterprise of the agriculture farming. The indigenous cattle are well known for their adaptability to the harsh tropical climatic conditions, ability to thrive in the resource poor production systems, better feed efficiency and disease resistance. Barring few dairy breeds, majority of the Indigenous cattle breeds are poor in their genetic potential for milk production. Considering the ever increasing demand from milk , the country has implemented many cattle improvement programmes like Central Herd Registration Scheme (CHRS), Intensive Cattle Development Programme (ICDP), All India Coordinated Research Project (AICRP) on Cattle National Programme for Bovine Breeding and Dairy Development (NPBBD), National Livestock Mission, National Project for Cattle and Buffalo Breeding (NPCBB), Rashtriya Gokul Mission (RGM) etc., for improving the milk productivity of cattle.

Energy is essential for each and every single biological reaction in the body of an individual. Production, reproduction and physiological functions of an animal depend on its body state and utilization of energy from dietary source and its body reserves. Energy reserves are determined primarily by the relative amount of fat accessible as an energy source and are indicative of health condition. Adipose tissue (AT) is a primary reservoir of energy and recognized as an immunologically and endocrinologically active tissue. Cattle have the ability to utilize body reserve to meet energy demand due to negative energy balance during peripartum period, which is crucial for maintaining their health lactation and neonates. There are several methods to measure tissue reserves like body weight, metabolic and hormonal factors, respiratory calorimeter body water by dilution with D2 O, estimation of fat cells diameter, ultrasound techniques etc. Body weight is not a good indicator as it is affected by different factors such as; age, parity, gestation, body frame, gastrointestinal contents weight of vital organs and shows a greater variation in measuring fat stores. Other methods are inapplicable in field conditions as they are costly, time consuming and need laboratory facilities and skilled technicians. However Body Condition Score (BCS) is an easier and the most practical method, which is an assessment of thickness of fat cover, prominence of bone of tail and head region.

Introduction

Coordinated and innovative efforts of government agencies and milk producers’ has immensely increased milk production and ushered in White revolution in India leapfrogging the country to the leading position in milk production (102 million tonnes) in the world. With an annual rate of 4-5% and with a share of 18% in the agricultural gross domestic product; milk is largest agricultural commodity in India (Economic Survey, 2007-08). However, the improvement in milk production in past few decades has not necessarily resulted in proportionate increase in profits to dairy farmers as animals with high milk production have increased frequency of health disorders.

Modern biological systems cannot be fully understood through a single molecular layer. This chapter examines the integration of genomics, transcriptomics, proteomics, and metabolomics to obtain a comprehensive systems-level understanding of biological processes. It explains the role of each omics discipline and shows how their combined analysis can connect genetic information, gene expression, protein activity, metabolic states, and phenotypic outcomes. The chapter discusses the need for multi-omics integration, computational and network-based analysis, and systems biology workflows. Applications include disease diagnosis, precision medicine, crop improvement, stress tolerance, biotechnology, metabolic engineering, synthetic biology, and environmental research. Multi-omics integration provides improved biological interpretation, biomarker discovery, pathway prediction, and therapeutic target identification.

Poultry industry in India has a strong standing globally, being third highest egg producer with more than 50000 million eggs and fifth highest broiler producer with 2.25 million tones of broiler meat. Largely, Indian poultry industry is chicken dominated and the rearing of high yielding varieties under intensive rearing system is the backbone of its present face. Analysis of trend of egg production in last five years i.e. 2001-2006 revealed that annual growth rate in egg production is about 5-6 %, except a much lower rate of 3 % during 2003.

I. PUBLIC POLICY CONCERNS

The working of the Trade Related Aspects of Intellectual Property Rights Agreement (TRIPS) Agreement, 1995 along with World Intellectual Property Organization (WIPO) and the jurisprudence developed for the last twenty years is a testimony to the fact that although TRIPS is geared to promote the protection of intellectual property rights internationally, yet some controversial public policy issues need to be addressed and solutions devised for addressing these public policy issues otherwise there is a possibility of seeing the demise of TRIPS Agreement or sidetracking it by some other methods which may not be conducive for maximizing the welfare of the international trading community. As all of us know that intellectual property and international trade are mutually inclusive and the minimum standards set forth in the TRIPS Agreement are economically value oriented. The trade offs among and between the members of the WTO need to be balanced on an even keel, otherwise the possibility of camaflouging the TRIPS Agreement and the attendant jurisprudence becomes real. The TRIPS Agreement addresses seven categories of IP rights such as; Copyright and related rights; Patents; Trademarks and Service marks; Geographical Indications; Undisclosed Information or Trade Secrets; Industrial Designs ; and Layout Designs of Integrated Circuits and read with other WIPO Treaties obligates the members of the World Trade Organization (WTO) to reduce distortions and impediments to international trade by taking into account the effective and adequate protection of intellectual property rights as well as the procedures for the enforcement should not become barriers to international trade. The TRIPS Agreement also recognizes the need to cater to the special needs of the developing and least developed countries.

Intellectual property (IP) encompasses creations of the human intellect, including inventions, artistic and literary works, as well as symbols, names, and designs. Intellectual property rights (IPR) are legal mechanisms thaprovide creators with exclusive rights to use, manage, and profit from their creations. These rights help protect the interests of innovators and promote continued creativity and innovation.
Intellectual Property Rights refer to the legal entitlements granted to individuals or organizations over their creative and intellectual works, such as patents, trademarks, and copyrights. These rights grant exclusive control or usage privileges for a specific duration, often creating a temporary monopoly. While the concept of intellectual property began to take shape in the 19th century, it was only during the 20th century that it was formally integrated into global legal frameworks.
Intellectual Property Rights (IPR) safeguard the creations of the human mind, such as inventions, artistic and literary works, brand names, logos, designs, and images used in commerce. These rights help foster innovation by allowing creators and inventors to benefit economically from their work.
Key Points
1. Intellectual Property Rights are legal protections acquired by creators or owners of intellectual works.
2. Intellectual property encompasses intangible assets that result from human creativity and thought.

Decision Support Systems convert farm data into recommendations that improve livestock productivity, health and sustainability. This chapter explains data-driven, model-driven and knowledge-based systems and their principal components: data management, analytical models and user interfaces. Technologies such as IoT, artificial intelligence, machine learning and cloud computing support applications in feed optimization, disease prediction, reproductive management, milk production and animal-welfare monitoring. Dairy and poultry examples demonstrate how DSS can reduce operational costs and strengthen farm decisions. Implementation challenges include inadequate data quality, high costs, limited technical expertise and maintenance requirements. Future systems are expected to integrate blockchain, robotics, Edge AI and increasingly autonomous management technologies.