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Synonyms : Catarrhal fever, Sore mouth, Epizootic catarrh, Sore muzzle, Pseudo foot and mouth disease, Malarial catarrhal fever.

It is an infectious, noncontagious arthropod borne viral disease of domestic and wild ruminants namely sheep, goat , cattle, camels, llamas, deer and antelopes. This is predominantly a disease of sheep but occasionally cattle and  goats are subclinically affected. The disease is characterized by high fever, catarrhal stomatitis, rhinitis, enteritis and lameness due to inflammation of the coronary bands and sensitive laminae of the feet. There are at least  25 serotypes of bluetongue virus worldwide within the BTV serogroup. Genetic variability occurs within a group due to genetic drift of individual gene segments and genetic reassortment when ruminants or other vectors are infected with more than one strain.

Body condition scoring (BCS), although subjective in nature, is the only practical method of evaluation of body energy stores in dairy cows. The method of body condition scoring, originally proposed by Edmonson et al. (1987) and recommended by the NRC (2001) is described here. This method uses a 5 point scale, with BCS of 1 being extremely thin and a score of 5 being extremely fat. This system includes a combination of both visual appraisal and manual palpation on 8 separate body locations. Figure 1 shows the suggested BCS chart based on these locations. The assessor can score the cows using this chart with a fair accuracy, without much previous experience of scoring the cows. The scoring method is recommended for HF and Holstein crossbred cows.

Loss of BCS is expected during early lactation when a cow is mobilizing body fat in support of energy needs for lactation. Typical observed changes in BCS range from 0.5 to 1.0 condition score units during the first 60 days postpartum. A 1-unit decrease in BCS for a cow weighing 650 kg at calving (BCS 4) would provide 698 MCal of ME.That amount of ME is sufficient to support 564 kg of 4 per cent fat corrected milk.

The body condition scoring (BCS) is a subjective estimate of the energy reserves in adipose tissues of an animal. It is an acceptive, non-invasive, quick and inexpensive method to estimate degree of fatness. It is a means of accurately determining body condition of dairy cows, independent of body weight and frame size. It is evinced that the profile of lactating cows in milch barn is different e.g. some may be in early lactation and the others may either be in mid or late lactation. The observations on body condition status of animal will help the manager to adopt corrective management measures, thus enabling to improve the production profile of an animal. Hence, body condition scoring may be used as an efficient tool in this regard. Although many may consider this as a nutritional management practice, but changing BCS have implications on milk yield, health, reproduction, longevity and overall profitability of an animal. Body Condition Scoring (BCS) is a system used to evaluate the overall health and nutritional status of animals by 

Water : Importance of Water in Physiological Functions of the Body

A large proportion of the body of mammals including domestic animals, is made up of water. This water is an essential attributes for the life of the animals. Animals deprived of food but provided water will survive much longer than the animals provided with food but deprived of water. Water is the basis of the liquid environment of the cells, which Claude Bernard called the milieur interieur, and Cannon the fluid matrix. Its most important biophysical qualities are its solvent properties, its ionization and its heat of vaporization. Water is essential for metabolic processes, as most of these reactions must occur in aquatic environment. Water provides the medium for the transport of nutrients from their sites of absorption to the site of metabolism. Water also provides the medium for the transport of waste products from their sites of production to their sites of final excretion. Together with the main electrolytes, water forms an excellent buffering medium. Moreover, water is an essential substrate or end product of many biological reactions. Water due to its high latent heat of evaporation or fusion is an excellent insulator for the loss of body heat and is essentially required for the loss of heat to maintain body temperature, through the evaporation of water from the skin and the respiratory tract. Water also acts as a vehicle for the transportation of nutrients, hormones, waste products and gases etc.

Body water is derived from several sources which include the water drunk, intake of water through food and metabolic body water. Water is lost from the body through several routes which include loss of water through the feces and urine, evaporation of water from the skin and respiratory tract.

The concentration of water in the body varies from one tissue to another, being least in the dentine of teeth and greatest in the grey matter of the brain. The amount of water in the body also varies considerably with the age of the animal. The younger animals contain considerably more water than the older animals. This effect is mostly due to increase in the fatty tissues in the body, which contains relatively much less water, as the relative composition of tissues of the body other than fat remains relatively constant. The proportion of water in ruminants is higher as compared to nonruminants.

The two different compartments of the body fluids are extracellular fluid (ECF) and intracellular fluid (ICF) with variation in solute concentrations.
The extracellular fluid is the fluid in the cardiovascular system or in between the cells, called interstitial fluid.

Centre of gravity

It is most commonly located is the middle of the rib cage, just caudal to the line separating the cranial and middle third of the body because the CG & located more cranially. The forelimbs bear 60-65% of body weight. This causes an increased stress of forelimb and increase incidence of lameness. The horse that is taller over the group than the wither has an additional disadvantage, because PTS CG is shifted further forwards.

1. Long backed horses may develop a swing in the gait that alters the movement of their limbs. Such horses are prone to speedy cutting. Cross firing & back problem due to muscle ligament strain.

2. Short backed horses may develop a swing in the gait that alters the movement of these limbs. Such horses are prone to speedy cutting, cross firing & back problem due to muscle and ligament strain.

1. Bone grafts

Bone grafting represents one of the earliest devised reconstructive approaches to the musculoskeletal system and remains among the most commonly used orthopedic procedures. Bone is the second most frequently transplanted tissue. The first recorded attempt to use bone graft is by the Dutch surgeon Job Van Meek’ren in 1668.

Definition

A graft is a living tissue that is transplanted to another site either within the same individual or into another individual for repair of a defect. An implant is a non viable material placed in a living system. Implants are composed of bone cement, metal or ceramic material. Grafts are structurally important for mechanical stability, but their use evolved to include the stimulation and enhancement of bone in response to injury.

Indications

Bone grafts are used, in general as framework, both to provide stability and to augment healing. It is used in the management of non union, delayed union, treatment of pseudoarthrosis, filling of osseous defects or cavities, arthrodesis, stabilization of spinal segments and addition of bone stock in total joint displacement.

Bone marrow is a soft, gelatinous tissue that fills the medullary cavities of bones. It plays a crucial role in the production of blood cells. It makes up about 3% of body mass in rats, 2% in dogs, and 5% in humans. Bone marrow develops in the embryo during the second trimester of pregnancy. This tissue is vital because it contains stem cells that can differentiate into various cell types. Bone marrow is of red and yellow types. In young mammals, the marrow is red and active (with minimal fat). With aging, accumulation of adipose tissue, and long bones transition turn bone marrow to yellow, fatty, inactive. In adult mammals, active hematopoiesis continues in flat bones, such as the sternum, ribs, pelvis, vertebrae, and skull, as well as the epiphyses of long bones. Erythropoiesis in these regions contributes significantly to red blood cell production, with the axial skeleton accounting for about 35% and the appendicular skeleton for 65%. In birds, hematopoiesis is mainly restricted to bone marrow, while in reptiles, it occurs in the bone marrow, spleen, liver, and thymus. Indications

In 1965, Urist demonstrates that the implantation of demineralized bone at extra skeletal sites induced de novo formation of cartilage and bone and proposed that the decalcified bone matrix possess high osteoinductive property and the inductor is a unique chemical that differentiates mesenchymal type cells (pericytes) into new bone. Urist and Starates (1971) reported that the inductor is a protein and termed it bone morphogenetic protein (BMP) . BMP is the bone induction principle.

Sources: Bone morphogenetic protein isolate from bovine as well as human bone and designated as bBMP and hBMP respectively. The molecular cloning of the bone morphogenetic proteins and their subsequent expression in recombinant system, resulted recombinant bone morphogenetic protein designated as rhBMP. BMP has been extracted from dentin and bone matrix, as well as from bone tumours, by enzymatic and nonenzymatic methods. The sources of BMP, thus far explored are rabbit dentin, rat, rabbit and bovine bone, human bone, mouse or human osteosarcoma and human placenta.

BMP circulates in the blood and it can be detected by BMP-radioimmunoassay. BMP levels higher in growing children (20-72 ng/ml) and patients with Paget’s disease (over 259 ng//ml) than in normal adults (14-18ng/ml). Crude and partially purified BMP has been extracted with the aid of collagenase, ethylene glycol, calcium chloride urea and Guanidine hydrochloride (GuHCL) solution. Wang et al (1988) purified BMP factor that induces bone formation> 300,000 fold from Guanidine chloride extracts of demineralized bone. As littlie as 50ng of this factor can induce the formation of cartilage and bone in an in vivo assay, though only 40µg could be obtained from 400kg of bovine bone powder.

DIGITS

Four digits are presents in the ox of these two the third and forth -are fully developed and have three phalanges and three sesamoid each.The second and fifth are vestiges.

FRIST PHALANX- (Fig.No.1)

The interdigital surface is flattened and its volor parts bears a prominence for the attachment of the interdigital ligaments.

The proximal extremity is relatively large and somewhat compressed from side to side.

The articular surface is concave from before backword and is divided by sagittal groove in two areas, of which the aboxial one is the larger and higher.

Behind tese are two facets for articulation with the sesamoid bones.

The distal extremity smaller than the proximal.

Aim

To know the various level of fracture & their appropriate method of immobilisation for large animal fracture.

Definition

Fracture is a disolution of bony continuity with or without displacement of the fragments.

Bone is an integral part of musculo-skeletal system of body. In the living animal it is bluish pink, whereas, fresh dead bone is yellowish-white in colour. It is hard and resistant to pressure but also have certain amount of elasticity. Its tensile strength is equal to the cast iron, though bone three times lighter and ten times flexible to cast iron.

Number of bones: The number of bones of the skeleton varies with age and species. Number of bones in cattle-210; Horse-208; Dog-271; Fowl-166 and human-208 (207-212)

Composition of bone: Bone contains different bone cells, organic and inorganic matrix and water. Organic matrix is about one-third and Inorganic matrix is two-third weight by volume. The organic material consists of 90% collagen [type-I (maximum), type V and type XII] and 10% non-collagenous glycoprotein and bone specific proteoglycans (osteocalcin, osteonectin, sialoprotein, bone phosphoproteins and small proteoglycans) and bone growth factors [TGF-beta family; Insulin-like growth factor-1, 2; bone morphogenetic protein (BMP); platelet derived growth factor (PDGF); Interleukin -1 (IL-1); Interleukin-6 (IL-6); colony stimulating factor]. Organic matrix of bone resembles the matrix of dense fibrous tissues such as tendons, ligament and joint capsule. It is not certain whether all of these proteins are synthesized by bone cells or whether they are synthesized by cells outside of the bone and then incorporated into the bone matrix. However, their presence within bone and their potential to affect the activity of bone cells suggests they have important role in controlling bone cell functions. Inorganic matrix of bone or mineral component of bone serves as an ion reservoir and gives bone of its stiffness and strength. It reserves 99% of body calcium, 85% body phosphorus and 40-60% body sodium and magnesium. Inorganic matrix of bone is composed of 85% calcium phosphate, 12% calcium carbonate, 3% of magnesium phosphate, calcium fluoride and magnesium carbonate. It also contains traces of chlorine, sodium, potassium. These minerals remain as hydroxyapatite crystal form within bone. However, bone mineral crystal is not pure hydroxyapatite, instead they contain both carbonate and acid phosphate groups (HPO₄) and bone crystal does not contain OH groups. Bone matrix has such great durability and stability that it can remain essentially unchanged and retain much of its strength for centuries after death. Removal of organic matters renders the bone fragile, brittle and shattered, whereas, decalcification renders bone soft and pliable and resistant to fracture.

Bone

Bones provide the rigid framework of the body of animals and man. The skeletal system serves three main functions. (1) It supports and protects the soft tissues and organs of the body. (2) It helps to maintain, through homeostatic regulation, the constancy of the ionic environment within the organism. (3) It helps in locomotion with the help of muscles and tendons.

The ends of long bone is called the epiphysis: the long, compact shaft, the diaphysis where it joins the epiphysis, the metaphysis. The diaphysis is composed of a hollow cylinder which contained the medullary cavity and bone marrow. During postnatal life, erythropoiesis occurs mainly in the bone marrow. In the adult, bone contains on wet weight basis approximately 25% water, 45 Percent ash and 30 percent organic matter. With increasing age, the ash content progressively increases as the water content decreases; the organic fraction remains relatively constant. Calcium constitutes about 37% of the ash content, and phosphorus about 18.5%.

FEMUR

The femur has a relatively small shaft, which is cylindrical in its middle. The trochanter minor has the form of a rough tuberosity.

The trochanteric ridge connects it with the trochanter major. The third trochanter is absent. The supracondyloid fossa is shallow. The proximal extremity is very wide.

The fovea capitis is a small depression on the middle of the heacKfor the attachment of the round ligament.

The trochanter major is very massive and is undivided; its lateral surface is very rough. The trochanteric fossa is deep. The ridges of the trochlea are less oblique.

The ilia are almost parallel to each other and form a much smaller angle with the horizontal plane than in the horses.they are relatively small. The glutei line is prominent and nearly parallel to the lateral border,it joins the ischiatic spine.A rounded ridge separates the two parts of pelvic surface.The surface for articulation with sacrum is triangular. The tuber coxae is relatively prominent and not so oblique as in horses, wide in middle,smaller at either end.Shaft is short and compressed from side to side.

Ischium is large.Its long axis is directed obliquely upward and downward forming an angle of 5o to 60 degree with horizontal plane.The transverse axis is obliquely downward and inward at similar angle so concave from side to side.Ventral surface has rough ridge for muscular attatchment. The ischiatic spine is high and thin and bears a series of vertical rough line. lschiuatic arch is narrow and deep.The tuber ischii is large and three sided bearing dorsal ,ventral, lateral tuberosities.The symphysis bears a ventral ridge which fades out at ischial arch.The acetabular branch of pubis is narrow and is directed laterally,and a little forward.The anterior border is marked by a transverse groove which ends below rough iliopectineal eminence. The symphyseal branch is wide and thin. The acetabulum is smaller than in horses. Rim is rounded and usually marked by two notches. One is directed to deep acetabular fossa and and converted to foramen. The other is anteromedial and small also replaced by foramen or absent.

Bones of the animal body makes a skeleton system and helps in locomotion and support soft tissues. The proportion of bones in animal body varies with the animal species as they contribute 12-28 percent in cattle and buffalo, 17-35 percent in sheep and lambs, 50percent in bobby calves, 25 percent in veal calves, 12-20 percent in pigs and 8-17 percent in poultry. As the age advances bones becomes rigid due to ossification of cartilages but in older age bones becomes brittle and fragile due to reduction in bone organic matter.

to be coccobacillary.They are strict aerobes and do not attack carbohydratesbut derive energy by the oxidation of amino acids. B. avium and B. bronchiseptica are motile by peritricholls flagella but B. pertussis and B. parapertussis are non-motile. All are catalase-positive and oxidase-positive. B. bronchiseptica and B. aium willgrow on MacConkey agar.
The genus Bordetella contains four species, B.pertussis, B.parapertussis, B. bronchiseptica and B. avium. Bordetella pertussis, the type species, and B.parapertussis are human pathogens associated with whooping cough in children. Bordetella bronchiseptica infects a wide range of animal species including man, while B.avium is a pathogen of avian species. The bordetellae are occasional pathogens which have an affinity for ciliated respiratory epithelium.
Bordetella bronchiseptica and B.avium are small (0.2 to 0.5 x 0.5 to 1.5 pm), Gramnegative rods with a coccobacillary appearance. They are catalasepositive, oxidase-positive aerobes and are motile peritrichous bacteria. Because they cannot utilize carbohydrates, they derive their energy mainly from the oxidation of amino acids and have no special growth requirements. They grow on MacConkey agar.
Natural Habitat
The bordetellae are inhabitants primarily of the upper respiratory tract of healthy and diseased humans, animals and birds. B. pertussis and B. parapertussis are human pathogens causing whooping cough and a mild form of whooping cough, respectively. B. bronchiseptica can be present in the upper respiratory tract of pigs, dogs, cats, rabbits, guinea-pigs, rats, horses and possibly other animals. B. avium inhabits the respiratory tract of infected poultry, principally turkeys. Mammalian infections are mainly transmitted by aerosols but in turkeys indirect spread can occur via water and litter.

Borreliae, which are longer and wider than other spirochaetes, have a similar helical shape. In addition to a linear chromosome, which is unique among bacteria, borreliae possess linear and circular plasmids. Although these spirochaetes can cause disease in animals and humans, subclinical infections are also common. Borreliae are transmitted by arthropod vectors.
Usual Habitat
Borreliae are obligate parasites in a variety of vertebrate hosts. Although these organisms persist in the environment for short periods, they depend on vertebrate reservoir hosts and arthropod vectors for long-term survival.
Differentiation of Borrelia Species
Borreliae can be differentiated from other spirochaetes by their morphology, by the low guanine and cytosine content of their genomic DNA and by ecological, cultural and biochemical characteristics. Identification of Borrelia species depends mainly on genetic analysis. At least nine genospecies or genomic groups of B.burgdorferi sensulato, have been identified using DNA-DNA hybridization, 16s rRNA sequencing and other molecular techniques.
Clinical Infections
The species of particular veterinary importance are B. burgdorferi sensu lato, the cause of Lyme disease in animals and humans, and B. anserina which causes avian borreliosis. The significance of two other species, B.theileri andB.coriaceae, as animal pathogens, is uncertain.
Lyme Disease
This condition, also known as Lyme borreliosis, was first identified in 1975 following investigation of a cluster of arthritis cases in children near the town of Old Lyme, Connecticut. The causative agent, a spirochaete, was named Borrelia burgdorferi.