eChapters

Introduction
Eye
Visual perception, eyesight, sight, or vision is the ability to interpret the surrounding environment using light in the visible spectrum reflected by the objects in the environment. The eyes are the sensory organs that are extension of the brain; they receive visual information from the environment and transmit them to the visual sensory area of the brain for interpretation.
The pineal and para-pineal glands are photoreceptive in non-mammalian vertebrates. Birds have photoactive cerebrospinal fluid (CSF)-contacting neurons within the paraventricular organ that respond to light in the absence of input from the eyes or neurotransmitters.
Accessory Structure of the Eye
Eyelids - (Palpebrae) The free margins of the eyelids form the palpebral fissure. The edges where the upper and lower eyelids meet are called the lateral and medial canthus. The palpebral margins are lined by eyelashes. The eyelids are supported internally by sheets of connective tissue that form the tarsal plate.
Glands associated with the eyelids
Glands of Zeis - These are sebaceous glands associated with the eyelashes.
Tarsal glands - (Meibomian glands) - These glands line the inner margin of the lid and
produce a lipid-rich product that prevents the lids from sticking together.
Lacrimal caruncle - This is a mound of tissue in the medial canthus that produces thick secretions.
Conjunctiva It is the epithelium that lines the inner surface of the eyelids and continueson to the outer surface of the eye.
Palpebral conjunctiva lines the inner surface of the eyelid.
Bulbar conjunctiva lines the anterior surface of the eye.
Lacrimal Apparatus It produces, distributes and removes tears. Tears reduce friction, remove debris, prevent bacterial infection and provide nutrients and oxygen for the conjunctiva. Lacrimal glands are located near the lateral canthus of the eye. Tears flow over the cornea and are drained into the nose by the nasolacrimal duct.

Introduction
Normal reproduction in the female depends on hormones, which specific chemical substances produced by specialized glands are called endocrine glands. These secretions pass into the blood and lymph fluids and are transported to various parts of the body, where they exert several specific effects. Reproductive hormones may originate in the hypothalamus, pituitary, gonads, uterus, or placenta. Hypothalamic hormones are produced
in the hypothalamus, a portion of the brain that is the neural control center for reproductive hormones. The role of hypothalamic hormones is to regulate the release of other hormones from the pituitary gland, and many hypothalamic hormones are therefore called releasing hormones. The primary releasing hormone of reproduction is gonadotropin-releasing hormone (GnRH). GnRH controls the release of follicle-stimulating hormone (FSH)
and luteinizing hormone (LH) from the pituitary gland, located at the base of the brain. These pituitary hormones regulate the production of estrogen and progesterone from the ovary. FSH stimulates the follicle’s growth, development, and function, while LH causes\= the follicle to rupture and the corpus luteum to develop. The female hormone estrogen is produced by the Graafian follicle on the ovary. Another hormone originating from the
ovary is progesterone, which is produced by the corpus luteum. Each has an important role in the female reproductive process.
A relatively new discovery in reproductive physiology is that follicular growth is not continuous in the bovine, but occurs in waves (2 to 4 waves per cycle). Each wave begins when the dominant follicle in the previous wave gains maximal size, at which time numerous small follicles begin a period of rapid growth. From this group of follicles, one follicle is allowed to grow to a much larger size than the others. This large follicle is called the dominant follicle, because it has the ability to regulate and restrict the growth of the smaller follicles. A few days after reaching maximum size, the dominant follicle begins to degenerate and die.

Bleeding disorders can be either congenital, present from birth, or acquired, developing later in life. Defects in blood clotting proteins typically result in delayed bleeding and deep tissue bruising, whereas platelet defects often lead to superficial bruises, nosebleeds, black stools, and prolonged bleeding at injection sites or during surgery. Blood clotting tests can identify animals with defective clotting proteins, but they are not very sensitive.
Congenital Clotting Protein Disorders
Congenital clotting protein disorders are present from birth, and severe deficiencies or defects in these proteins typically manifest early in life. Such severe defects can be fatal, with affected animals often being stillborn or dying shortly after birth. Additionally, a lack of clotting proteins or vitamin K in a newborn can exacerbate clotting issues. If the level of a specific clotting protein is only 5 to 10% of normal, the newborn might survive but is likely to show signs of illness before reaching 6 months of age.
Hypofibrinogenemia, characterized by an abnormal shortage of fibrinogen in the blood and severe bleeding, has been observed in Saint Bernards. Dysfibrinogenemia, which involves abnormally functioning fibrinogen, has been reported in an inbred family of Russian Wolfhounds. Affected dogs experience mild bleeding problems, such as nosebleeds, but may suffer life-threatening bleeding from injuries or surgeries. The best treatment for this condition is intravenous transfusion with fresh or fresh-frozen plasma.
Factor II (prothrombin) disorders are rare. Prothrombin is a key protein in blood clotting. In Boxer dogs, prothrombin is present in normal amounts but does not function properly. Affected puppies may experience nosebleeds and bleeding gums, which tend to improve with age. In adult dogs, easy bruising and inflamed skin are common. Treatment involves transfusions of whole blood or plasma Factor VII deficiency has been reported in several breeds, including Beagles, English Bulldogs, Alaskan Malamutes, Miniature Schnauzers, Boxers, and mixed-breed dogs. This condition can lead to prolonged bleeding after giving birth and is often diagnosed incidentally during clotting tests.

Introduction
The haematological system, essential for sustaining life and comprising blood and its components, is fundamental to human and animal physiology. Blood is a unique connective tissue that performs several critical functions, including transporting oxygen, nutrients, and hormones to cells and removing metabolic wastes. It also plays a pivotal role in immune response, haemostasis, and the regulation of body temperature and pH. This
section provides an in-depth overview of the clinical physiology of the haematological system, covering the composition of blood, haematopoiesis, haemostasis, and common haematological disorders. Blood is composed of two main elements: plasma and blood cells. Plasma, the liquid component, constitutes approximately 55% of blood volume and consists predominantly of water, electrolytes, proteins, waste products, and dissolved gases. Plasma is the medium for transporting nutrients, gases, hormones, and waste products throughout the body. It contains important proteins such as albumin, which maintains osmotic pressure; globulins, which are involved in immune responses; and fibrinogen, which is crucial for blood clotting. The blood cells include erythrocytes (red blood cells), leukocytes (white blood cells), and platelets. Erythrocytes are the most abundant cells in the blood, with the primary function of transporting oxygen from the lungs to tissues and carbon dioxide from tissues back to the lungs. This is facilitated by haemoglobin, an iron-containing protein within erythrocytes that binds to oxygen. The lifespan of an erythrocyte is approximately 120 days, after which it is phagocytosed by macrophages, which are a type of myeloid phagocytic cells in the spleen and liver. Leukocytes are integral to the immune system, protecting the body against infections and foreign pathogens. They are categorized into granulocytes (neutrophils, eosinophils, and basophils) and agranulocytes (lymphocytes and monocytes).

Introduction
The testicle is a unique and important reproductive organ that serves two main purposes. The primary purpose is the development of mature spermatozoa that are able to fertilise the egg.The production of hormones, which plays a role in ensuring that mature spermatozoa are delivered to mature eggs where fertilisation may take place, must be considered a supplemental function to the development of germ cells. The induction of behavioristic
reactions—also referred to as sex drive or mating instincts—and the provision of a means of transportation for spermatozoa, as well as the regulation of ejaculate—either its release into the aquatic medium surrounding the egg in the case of lower vertebrates or its introduction into female passages through an organ of intromission—are the two concrete necessities involved. The animal loses its ability to reproduce as long as either the production of germ cells or the propensity to mate is impaired, even though the two processes undoubtedly work in tandem to achieve the end result.

Introduction
The nervous system in animals is a complex group of highly specialized cells capable of collecting and transmitting information in response to external stimuli via receptors and highly specialized sensory organs. It aids in the regulation of muscle coordination, the release of hormones, neurotransmitters, and other chemical mediators, all of which facilitate numerous bodily activities.
The nervous system is divided into two systems: the central nervous system (CNS), which includes the brain and spinal cord, and the peripheral nervous system. Within these systems, there is another autonomic nervous system (ANS), which is distinguished by higher centers of the hypothalamus, midbrain, pons, and medulla, as well as tracts and nuclei in the spinal cord. The ANS is further divided into sympathetic and parasympathetic
systems, which help maintain homeostasis and activate emergency mechanisms in response to external stimuli. The brain is normally covered by three meninges: piameter, arachnoid, and durameter. These meninges create three spaces: the subarachnoid space (between pia mater and arachnoid), the subdural space (between arachnoid and dura mater), and the epidural space (between dura mater and the ligamentum flavum in the spinal canal). The subarachnoid space includes cerebrospinal fluid, which is isolated from cerebral blood by the morphological and enzymatic activity of cells with tight junctions that regulate intercellular diffusion and solute exchange inside the cells. These cells form a barrier known as the “blood-brain barrier”.
The blood-brain barrier works as a selective permeable membrane, allowing only certain chemicals and medications to pass through while excreting essential components from the central nervous system via energy-dependent efflux pumps like p-glycoprotein. These proteins are encoded by genes such as ABCB1, and mutations in them can result in severe effects such as Ivermectin poisoning in the Colie breed of dogs. Similarly, it aids in the relative isolation of the neurological system from the immune system by establishing an immune-suppressive parenchymal milieu. However, various infections, trauma, and developmental defects can result in underdevelopment or damage to different cerebellar structures. As a result, depending on the portion implicated, it might cause changed behavioral changes in animals such as muscle incoordination, depression, and paralysis. These clinical symptoms may be excitatory.

Introduction
Respiratory diseases are a common clinical issue in dogs, particularly in those housed in environments like pet shops, shelters, breeding and boarding kennels. Puppies and senior dogs are at a higher risk of developing respiratory infections compared to adult dogs. The respiratory system is one of the body’s four major systems, comprising the upper airways (pharynx, larynx, and trachea and the lower airways (bronchi, bronchioles, and
alveoli). The pharynx, which serves as a common passageway for both the respiratory and gastrointestinal systems, explains the relatively high incidence of aspiration pneumonia. The luminal diameter of the pharynx is the widest, followed by the larynx and trachea.
The ratio of tracheal diameter to thoracic inlet height (TD:TI) remains relatively constant, regardless of the animal’s size or respiratory phase. The respiratory tract is typically protected from harmful pathogens by physical, chemical, and immunologicbarriers, including mucus, mucociliary clearance, innate antimicrobial factors, alveolar macrophages, and the pulmonary immune response. The entire respiratory tree is lined with ciliated epithelial cells, except for the bronchioles, which are lined by non-ciliated granular secretory cells known as club cells. The respiratory system’s primary function is achieved through four major processes: pulmonary ventilation; diffusion of oxygen and carbon dioxide between the alveoli and the blood; transport of these gases in the blood and body fluids to and from the body’s tissue cells; and regulation of ventilation and other respiratory factors. The pulmonary alveoli, the main sites for gas exchange between air and blood, are highly vulnerable to injury if the body’s defense mechanisms are compromised, underscoring the importance of prompt emergency treatment for respiratory diseases

Introduction
The skin, also known as the integumentary system, is the largest organ of the human body and protects animals from external factors. It consists of different tissues (epidermis, dermis, hypodermis, glands, hair and nails) and plays an important role in maintaining homeostasis, especially in regulating body temperature, protecting the body from damage and sensing the outside world. The skin consists of three main layers: epidermis, dermis and subcutaneous tissue; each has its own specific function. The epidermis is the outermost layer of keratinocytes that produce keratin as a protective layer. The dermis, beneath the epidermis, is rich in collagen and elastin, which give the skin strength and elasticity. The subcutaneous tissue beneath the dermis consists of fatty tissue and acts as an insulator for the body. Dermal fibroblasts are the primary cells that synthesize and maintain the skin’s extracellular matrix, contributing to its structural integrity and function. The integumentary system also plays an important role in regulating temperature, providing sensation, synthesizing biochemicals, absorbing nutrients, and protecting the body from various types of damage. In general, the integumentary system plays an important role in the body’s overall health and function by regulating body temperature, providing a sense of well-being, producing important biochemicals, absorbing nutrients, and protecting the body from external factors.

Introduction
The renal system is primarily responsible for the filtration of waste products from blood plasma through urine production. The kidneys, along with the ureters, bladder, and urethra, are part of the urinary system responsible for removing waste products from blood and eliminating them in urine. They filter around 120 ml of blood plasma per minute and perform homeostatic roles such as regulating blood volume and pressure, pH and electrolyte
composition, stimulating erythropoiesis, and supporting vitamin D biosynthesis. Nephrons, with around 1-1.3 million per adult kidney, are primarily cortical, with 80-85% of them located in the renal cortex. The remaining 15-20% are called juxtamedullary nephrons. The kidneys remove nitrogenous compounds like urea, uric acid, and creatinine, as well as metabolic waste products, toxins, excess hormones, water, and electrolytes. Urine formation involves three main stages: glomerular filtration, tubular reabsorption, and secretion. The kidneys produce renal filtrate, which contains blood components that can be filtered out, and the body recovers 99% of the water and electrolytes from the filtrate. The renal corpuscle, comprising the Bowman’s capsule and glomerular capillaries, is responsible for filtration of blood plasma and producing renal filtrate. Its structural elements allow
for efficient filtration, with glomerular capillaries having a 100-fold greater permeability to water, small ions, and solutes. The glomerular capillaries also have increased pressure due to the smaller diameter of the efferent arteriole. The filtration membrane consists of endothelium, basement membrane, and podocytes. The proximal convoluted tubule in the kidneys plays a crucial role in reabsorption of water and electrolytes, including sodium,
chloride, potassium, calcium, and bicarbonate. It reabsorbs approximately 80% of filtered bicarbonate, with further reabsorption from the loop of Henle and distal convoluted tubule. This reabsorption regulates the body’s acid-base balance, contributing to the acidic nature of urine. The proximal convoluted tubule is the only region able to reabsorb glucose. The loop of Henle is a crucial region in the kidney, responsible for concentrating urine and facilitating water and electrolyte reabsorption. It regulates fluid volume, blood pressure, and acid-base balance through bicarbonate reabsorption. The loop consists of two main regions: the descending limb and the ascending limb.

Creatinine Clinical significance Creatinine is produced at a steady rate due to muscle catabolism and is not reabsorbed by the kidney tubules after filtration. Its measurement provides an indirect assessment of the glomerular filtration rate (GFR). Unlike urea it is not markedly affected by diet or any aspect of liver function and therefore the test is more specific for renal dysfunction

Sodium Clinical Significance Compared to potassium, sodium is distributed differently throughout the body. Due to the sodium pump mechanism, most sodium is extracellular. Compared to this, just 2% of potassium is extracellular; the remainder is intracellular. Regarding the plasma concentrations of sodium and potassium, renal function is the single most significant homeostatic mechanism.

Clinical Significance The primary aim of laboratory diagnosis is to assess the carbohydrate metabolism impairment in diabetes mellitus, inducing the following: 1. Determination of glucose concentration in fasting blood and demonstration of postprandial glycosuria. 2. Assessment of glucose tolerance

A. Triglycerides Clinical significance To form lipoproteins, triglycerides combine with cholesterol, phospholipids, and plasma proteins. To determine whether hypertriglyceridemia may be present, the serum triglyceride concentration is measured (increased blood and serum levels of triglycerides). Chylomicrons and very low density lipoprotein (VLDLs), which cause the extensive lipaemia frequently observed in serum or plasma samples, are both mostly composed of glycerides.

Calcium Clinical Significance Calcium is an essential mineral which is involved in many body systems. These include the skeleton, enzyme activation, muscle metabolism, blood coagulation and osmoregulation. In the blood calcium exists as 50% ionized, 40% protein bound and 10% complexes with anions such as citrate and phosphate. Only ionized calcium is biologically active in bone formation, neuromuscular activity, cellular biochemical processes and blood coagulation. Factors governing the total plasma concentration are complex and include interaction with other chemical moieties, proteins and hormones. Calcium, phosphorus and albumin metabolism are interdependent.

The liver produces the entire albumin and most of the globulin; a small amount of gamma globulin is produced by retculoendothelial tissue. The production of albumin is subject to a mechanism regulating colloidal osmotic pressure and the secondary to alterations in globulin concentration. The liver synthesizes lipoproteins, glycoproteins, mucoproteins, fibrinogen, prothrombin and clotting factors VII, VIII, IX and X.

• Nutritional diseases

 • Viral diseases

 • Prion, Mycoplasmal, Rickettsial, Chlamydial, Spirochaetal and Bacterial

diseases

 • Fungal diseases

 • Parasitic diseases

 • Toxic conditions

 • Miscellaneous conditions

Cloud computing and Edge AI provide complementary infrastructure for intelligent livestock management. Cloud platforms offer scalable storage, centralized analytics, model training and integration of data from sensors, cameras, automated feeders and farm-information systems. Edge AI processes information close to the farm, reducing latency, bandwidth consumption and response time. This chapter explains their architectures, workflows and applications in dairy, poultry, swine and small-ruminant production. Uses include disease detection, estrus prediction, behavioural monitoring, feeding and environmental control. Hybrid cloud-edge systems balance centralized intelligence with local autonomy. Challenges involving connectivity, interoperability, cybersecurity, cost, model reliability and ethical animal surveillance are also critically examined.

Total Intravenous Anaesthesia
Maintenance of anaesthesia, conventionally, is done either with inhalants, or as intermittent boli of injectable anaesthetics. The pharmacological complexity of the uptake and elimination of inhalant anaesthetic agents, and the need of technical and functional knowhow, of inhalant anaesthesia machine, either restricts its use in majority clinical practice, or is not used in an ideal manner. Injectable anaesthetic drugs as intermittent boli “as and when needed” is the practice by majority practitioners for maintenance of anaesthesia. Intermittent bolus injections of anaesthetic drugs creates intermittent peaks of anaesthesia and thereby increased side effects due to high doses. Instead, a continuous rate infusion of the anaesthetic drugs, in smaller quantities is employed in TIVA, providing balanced anaesthetic maintenance. These drugs act through different pathways, providing analgesia, muscle relaxation and unconsciousness, in a synergistic manner. TIVA is thus a technique in which anaesthesia is maintained solely through the use of intravenous drugs, without reliance on inhaled anaesthetics (Kennedy, 2016). Total intravenous anaesthesia is commonly achieved using a combination of sedative-hypnotics, analgesics and even muscle relaxation drugs, often administered via continuous rate infusion (CRI) to maintain stable drug levels (Verma et al., 2020). The key advantage of TIVA is that it provide stable haemodynamics because it maintains the sympathetic tone well. Also, this procedure promises less environmental contamination avoiding exposure to anaesthetic gas in the operating rooms. TIVA is emerging as a popular option in a range of surgical procedures due to its benefits in patient comfort, recovery, and control over anaesthesia depth. Few examples of anaesthetic cocktails for total intravenous anaesthesia in dogs through constant rate infusion are mentioned below. Easy understanding on how to calculate and prepare CRI is mentioned later.
1. Dexmedetomidine (2 mcg/kg/hr), midazolam (3 mcg/kg/min), lignocaine (50 mcg/kg/min) and ketamine (40 mcg/kg/min) as a cocktail intravenous infusion in normal saline. Anaesthesia is induced by intramuscular administration of a cocktail of DBMK mentioned in earlier chapter, followed by an intravenous loading dose of lignocaine at the rate of 2 mg/kg prior to the cocktail intravenous infusion (Verma et al., 2020).
2. Xylazine (1 mg/kg/hr), midazolam (3 mcg/kg/min), lignocaine (50 mcg/kg/ min) and ketamine (40 mcg/kg/min) as a cocktail intravenous infusion in

Introduction
At the end of gastrulation, the mesoderm of the developing embryo differentiates into three regions: paraxial, intermediate, and lateral mesoderm. These regions play crucial roles in the formation of various body structures. As development proceeds, clefts form in the lateral mesoderm, which later coalesce to form a cavity. This cavity splits the lateral mesoderm into two layers: the somatic (outer) layer and the splanchnic (inner) layer. The space between these layers on each side of the midline becomes known as the coelomic cavity. These left and right coelomic cavities extend cranially, meet in front of the developing neural and cardiogenic plates, and fuse to form a horseshoe-shaped coelomic cavity. The walls of the developing coelomic cavity have two layers. The outer layer consists of somatic mesoderm, which fuses with ectoderm to form the somatopleure. The inner layer consists of splanchnic mesoderm, which fuses with endoderm to form the splanchnopleure. The mesodermal cells lining the coelomic cavity differentiate into a simple squamous epithelium called mesothelium. As cranial, caudal, and lateral folding occurs during embryonic development, the convex region of the horseshoe-shaped coelom eventually takes a ventral position to the foregut and developing heart, forming the primordium of the pericardial cavity. The developing coelomic cavities, initially continuous with one another at the umbilicus, become separated into intra-embryonic and extra-embryonic regions. The intra-embryonic coelom gives rise to the pericardial, pleural, and peritoneal cavities, while the extraembryonic coelom is associated with the developing fetal membranes. As the embryo folds laterally, the coelomic cavity divides into two separate components. The pleural cavities, which surround the developing lungs, are initially part of the pleuropericardial cavity, alongside the developing heart. As mesodermal folds, known as pleuropericardial folds, grow medially, they enclose the common cardinal veins and the phrenic nerves. These folds eventually separate the pleuro-pericardial cavity into two parts: the pleural cavities dorsally, and the pericardial cavities ventrally. The developing lungs grow

• These are the injuries occurred to male animal at the time of natural mating. These injuries do not occur only to genital organs but also to other organs or muscles. • Most coital injuries occur to male animal with good libido (high testosterone level) but having aggressiveness and poor experience of mating. Such animals tend to quick response in the presence of estrous female. Some of the coital injuries are: 1. Balanitis and Posthitis • Trauma to the penis and prepuce which later on leads to infection and inflammation. • This occurs especially in young inexperienced bulls with great sexual desire • Adhesion may lead to phimosis or paraphimosis condition • IBR-IPV infection from cow genitalia after mating results in pus formation and necrosis of the penis and prepuce. • Prepucial eversion leads to laceration and bleeding.