eChapters

Histomoniasis is a protozoan disease.

Etiology

Histomonas meleagridis.

Hosts

Mainly disease of turkey but has also been reported in chickens, peafowl, grouse, quail and gallinaceous birds.

Mammary tumours arise from the ducts are called as ductal or ductular carcinoma. Some include other tissues such as the myoepithelium and connective tissue between the glands. These have a number of different names including carcinosarcoma, carcinoma or sarcoma in benign tumour, complex adenocarcinoma and malignant mixed tumour. Tumours are also classified by the type of epithelial growth because this influences the probability of recurrence. Tumours that only have myoepithelium or connective tissue are called sarcomas.

• General considerations

 • Scope

 • Microscopic examination techniques

 • Smear

 • Vital staining

• Routine histopathological techniques of sectioning

 • Collection of tissues

 • Fixation

 • Washing

 • Dehydration

 • Clearing

 • Impregnation

 • Casting of blocks

 • Trimming

 • Section cutting

This chapter introduces the historical development and fundamental concepts of immunology. It highlights the contributions of Edward Jenner, Louis Pasteur, Elie Metchnikoff, Paul Ehrlich, Emil von Behring and other pioneering scientists. Important discoveries related to vaccination, phagocytosis, antibody formation, cellular immunity, ELISA, radioimmunoassay and hybridoma technology are addressed. The chapter also explains antigens, immunogens, epitopes, haptens, adjuvants and the desirable characteristics of an effective immunogen. Questions concerning smallpox and rinderpest eradication, vaccine development and primary and secondary immune responses help readers understand the scientific milestones that established immunology as an essential discipline within veterinary and biomedical sciences.

In pigs, making a diagnosis of disease is no way different from that of other species. It is based on assessing the owner’s complaint, history of the farm and the ailing pig, signalment factors, detailed observations of the ailing pig, the other pigs in the group and their environment, detailed physical examination. These observation may lead to a provisional diagnosis. Further clinical tests, clinical pathology and a post-mortem examination of the dead pigs are to be taken up to confirm or refute the provisional diagnosis. Because pigs are kept in groups and owing to infectious nature of many diseases, the health of other pigs in the group should also be taken into account. History and General Examination General examination of swine is conducted without handling them. The physical examination of swine includes history taking, examination of environment, examination of group of swine, post mortem examination

Study of animal diseases at patient bed side for diagnosis, prognosis, monitoring and treatment comes under

a) Veterinary Epidemiology b) Preventive Medicine

c) Veterinary Jurisprudence d) Veterinary Clinical Medicine

Veterinary Clinical Medicine is a subset of Veterinary Medicine, and refers to study on animal diseases at the patient bed side for diagnosis, monitoring,
prognosis and treatment of the disease. The Veterinary Medicine is that branch of veterinary science that deals with diagnosis, treatment, prevention and control
of diseases, disorders and injury in domesticated, pet, wild, zoo, captive, freeliving animals and birds.

History and History Taking History in medical/ veterinary terminology is a record of information about the health, illness (past and present), diet, feeding, management,preventive health schedules (vaccination,deworming, dipping, sprays) and hygiene etc. History taking and physical examination is the important step in making a correct diagnosis as it provides valuable information to determine the cause of clinical manifestations. The main purpose of taking history is to get detailed information about the animal, its activities, behavior, diet, health care practices, nutritional status, housing, development of abnormal signs and treatment given, if any. The animal may be cared by owner himself or by an attendant. In the event of animal care given by an attendant, information obtained from the attendant may not be complete and fully reliable as sometimes attendant may not provide correct events and complete picture to hide his mistakes. For obtaining right information a good rapport is to be made with the owner or the attendant. A complete history not only suggest diagnostic possibilities but can also suggest diagnostic probabilities. For example a calf or heifer is unlikely to have Johne’s disease or an adult cow is more likely to suffer from parturient paresis than a first calf heifer. History can also provide a lead for further examination or which system is to be paid special attention.

Making a correct and an early diagnosis is very much important for undertaking rational and effective treatment for fast recovery, avoiding unnecessary medication, reducing the load of so many drugs on body metabolism, reducing environmental pollution and the cost of treatment. There are four important pillars for making a correct diagnosis viz. the history, the systematic clinical examination, the correct clinical diagnostic techniques and the laboratory support. History Taking Clinician’s first step in making a diagnosis is through asking the owner’s complaint. Accurate and complete history may be obtained from focusing on the details of the patient (name, number, species, breed, age, sex and weight), vaccination status, deworming schedule, nutritional history, past and present medical history and environmental history.

History and thorough physical examination is crucial procedures in making diagnosis in horses. Mental attitude of a horse may help in understanding whether it has a localized problem or is systemically ill. Horse is better approached by its left side, keeping himself/herself next to the shoulder. Examination of the horse should be started in a non-threatening, easy, and quiet way. Generally physical examination starts at the head to prevent possible injury to unfamiliar examiner. Abnormalities in demeanor and mentation can be assessed by watching the horse’s initial response to the environment. The locomotor and neurologic systems are examined by observing the horse’s movements and gait at walk and trot, both on straight line and in turns, and backing. Horse weight should be taken. General inspection of the horse should be conducted by standing back keeping a safe distance and looking at the horse for it condition, abdominal shape, muscle symmetry,

Small ruminants are grazing mammals and this group consists of sheep (Ovis aries) and goats (Capra hircus).Advantage of these animals is their low cost, small size and marginal land use, which convert into high quality animal products. Sheep is a grazing animal and goat is a browsing animal. They are generally kept in flock. Therefore flock management is more important than the individual animal. Though, procedure of history taking and physical examination is almost similar to other animals, some peculiarities warrant a separate discussion. Sheep The general methods of history taking and physical examination of sheep are similar to cattle and goat starting from owner’s complaint (history), signalment of the patient, history of the ailing

Synonym – Cutaneous ancylostomiasis

Etiology

Hook worm dermatitis is uncommon or rare skin disease due to larval migration of the normal life cycle of Ancylostoma braziliensis and Ancylostoma caninum. It is mainly due to hypersensitive reactions against migrating third stage larvae in the distal extremities.

Introduction

During transition period and lactation, the high-producing dairy cows undergo a period of extensive tissue catabolism because of negative nutrient balance. Homeorrhetic mechanism at this stage ensures that nutrients are partitioned to favour the growth of fetus prepartum and meet the demand of nutrients in early lactation. Simultaneously the homeostasis secures survival of the animal body functions. However, a decline in feed intake in transition period leads to metabolic disturbances and low milk production in early lactation. The postpartum negative nutrient balance impairs immune and reproductive functions in dairy cows and buffaloes. The increased demand for nutrients and decreased dry matter intake results in low circulating glucose and insulin levels and elevated non-esterified fatty acids (NEFA) and ketone bodies postpartum. The energetic status of a cow or buffalo modulates the secretion of hormones that play key roles in growth of ovarian follicles, ovulation, corpus luteum (CL) formation, and oocyte competence. The NEBAL not only limits milk production potential but also has a detrimental effect on immune cells. Negative nutrient balance is associated with changes in the pattern of ovarian follicle growth and oocyte quality and alteration in endocrines. In addition, cows under negative nutrient balance have extended periods of anovulation. These changes could be minimized by supplementing energy rich supplements like prilled fat or any bypass fat preparations.

The aim of any good zoo should be to recreate the habitat from which the animal came as accurately as possible, with enough space to move around and enough stimulation so that they can behave naturally. Monkey cages should have plenty of branches for them to swing from and bird cages should have enough room so that they can fly. Some zoos hide the lionís or tigerís food so that they have to use their senses to explore and find it.

Duck farming in India is characterized by nomadic, extensive, seasonal, and is still held in the hands of small and marginal farmers. Traditionally Assam, West Bengal and Kerala are the major consumer states for duck egg and meat and one of the reasons is that duck egg and meat highly suits and impart taste for their fish based culinary preparations.

Different housing system for Duck rearing

In general, ducks do not require elaborate houses. The house should be well ventilated, dry, and rat proof. In semi-intensive system of rearing, the house should have easy access to outside run as the ducks prefer to come out during the day time, winter and rainy time. 

This chapter introduces hybridoma technology and its application in producing monoclonal antibodies. It explains the fusion of antibody-producing B lymphocytes with immortal myeloma cells, selection in HAT medium and the roles of HGPRT and polyethylene glycol. The survival and cloning of hybrid cells and the advantages of monoclonal antibodies are considered. The chapter also discusses tissue and organ transplantation, including autografts, isografts, allografts and xenografts. The immunological mechanisms of acute graft rejection, donor histocompatibility antigens and the involvement of T lymphocytes are addressed. These questions connect laboratory antibody production with transplantation immunology and its diagnostic, therapeutic and research applications.

Etiology

Group 1 adenovirus. First reported in Pakistan in 1987, where it caused a devastating effect on broiler industry. It has spread to all continents.

This chapter explores the four types of hypersensitivity reactions described under the Gell and Coombs classification. Type I immediate hypersensitivity, Type II cytotoxic reactions, Type III immune-complex disease and Type IV delayed hypersensitivity are examined in detail. The roles of IgE, mast cells, basophils, antibodies, complement and T lymphocytes are highlighted. Clinical examples include anaphylaxis, milk allergy, haemolytic disease, transfusion reactions, serum sickness, glomerulonephritis, farmer’s lung and the blue-eye condition associated with canine hepatitis. Diagnostic applications, including the tuberculin and Coombs tests, are also addressed. The chapter explains how exaggerated or inappropriate immune responses can damage tissues and produce disease.

Definition

Hypersensitivity is an altered reaction to a specific antigen that results in pathologic reactions upon the exposure of a sensitized host to that of specific antigen.

Explanation

Hypersensitivity reactions are inappropriate or misdirected responses to a specific antigen that result in harmful reactions upon exposure of a sensitized host to that specific antigen.

Affected animals require a sensitization phase in which the animal must have had either a previous exposure or a prolonged exposure to the antigen so that it can develop an immune response to the inciting antigen.

The harmful effects resulting from hypersensitivity reactions occur in the effector phase and are most commonly manifested through inflammation or cell lysis.

Key Points

• Physical cooling is more effective in managing hyperthermia.

• Heat stroke occurs when the cause is solely physical.

Introduction

Hyperthermia is an unusually high body temperature (also known as overheating) caused by the body absorbing or producing more heat than it can discharge. Simply said, it is the increase in temperature above the critical point. Heat stroke is most common in animals when they lose control of their body temperature.