eChapters

1. Introduction

Protein–protein interactions serve as the hub of the functioning of a living cell, coordinate biological processes as well as form core for interactomics system of living organisms. Various biological processes as signal transduction, cell-cell communication, ingestion or expulsion of any macromolecule, host parasite interaction, diseases as cancer and many other metabolic networks employ protein–protein interactions. During such a process two or more proteins interact transiently with each other or form complex for a long period of time. Thus attempts have been made for years to study comprehensive mechanism of such protein–protein interactions by various branches of sciences such as biochemistry, quantum chemistry, molecular dynamics, chemical biology and signal transduction. The availability of three-dimensional (3D) structure of proteins is a prerequisite for understanding functions of protein complexes at a molecular level as well as amino acid interactions within a complex.

Key words : CAVD, Drug Design, Bioinformatics, CADD, Co-factor, Vaccinology, infectious diseases, Jenner, immunity, Molecular modeling, Immunoinformatics, Antigen, Antibody, Live Vaccine, Alive Vaccine, Protein-peptide, Enzyme, Tools for Vaccine design,
 
Vaccine – Prevention is Better than Cure

A vaccine is a biological preparation that improves immunity to a particular disease. A vaccine typically contains an agent that resembles a disease-causing microorganism, and is often made from weakened or killed forms of the microbe, its toxins or one of its surface proteins. The agent stimulates the body’s immune system to recognize the agent

Introduction

Data Mining is a complex subject that describes a type of database application used to search large amounts of data for patterns using specific tools. Advanced statistical methods and tools such as classification, association rule mining and cluster analysis search large volumes of data for previously unknown relationships within the data. Data Mining can be used to decipher trends in a wide variety of fields such as computer science, the marketing and advertising of goods, services or products, artificial intelligence research, biological sciences and high-level government intelligence. Data mining is a logical process that is used to search through large amounts of information in order to find important data.

Databases

A database is a collection of information that is organized so that it can easily be accessed, managed, and updated. Databases can be classified according to types of content: bibliographic, full-text, numeric and images and by their application area, for example: accounting, music compositions, movies, banking, manufacturing, or insurance. The term database may be narrowed to specify particular aspects of organized collection of data and may refer to the logical database, to the physical database as data content in computer data storage or to many other database sub-definitions.

Abstract

Last few decades have witnessed an immense technological advancement in the education sector in India. With an advancement of technology, new gadgets are flooding the Indian market continuously bringing an immense opportunity for the education sector to improve upon the course delivery system. Higher education sector in India is adopting such new technologies in course delivery at a slow pace; however, there remains still a far way to traverse for the Indian education sector in order to achieve a perceptible and effective technology-infusion in the academic delivery arena. This paper is devoted to present an expository review on the usefulness of new gadgets, like smart phones, e-book reader as well as tablet PC, in both class-room education-delivery segments as well as in distance education sector in India.

Abstract

Fusion is a well known entity in various fields (e.g. medical imaging, weapon detection, flood monitoring etc.) that surmises information originating from several modalities. This chapter is an attempt to assort the various image fusion techniques available for human face recognition and to put a review of the advancements being made by the different researchers. The various types of fusion those have been used or may be used for face recognition have also been discussed here.

1. Introduction

With the fairly recent advent of inexpensive, rapid sequencing technologies that continue to improve sequencing efficiency and accuracy, many species of animals, plants, and microbes have annotated genomic information publicly available. It is important to use this genomic information for the identification and isolation of novel and superior alleles of important genes from gene pools of the organisms

Abstract

The study of computational toxicity prediction is very crucial and necessary, as it is quite time consuming and expensive to measure the toxicity via experimental techniques (Quan Liao et al., 2006). The use of computational approaches particularly to reduce the time and cost for the evaluation of the kinetic and toxic behaviour of any drug has been increased tremendously in recent time period (Richard Judson et al., 2004). Machine learning is a powerful tool to discover new complex combinatorial relationships in various in vitro and in vivo data information (Richard Judson et al., 2004) and has been successfully used in many diverse fields with numerous applications such as pharmacodynamics properties prediction (Czerminski et al., 2001; Livingstone et al., 2003), protein function prediction (Cai et al., 2003), medical decision making (Veropoulos, 2001), spam categorization (Drucker et al., 1999), detection of oil spills (Kubat et al., 1998), and speech recognition (Nuttakorn et al., 2001).

Introduction

The capabilities and effort to collect the geographic data has increased dramatically in the last decade to cope up with the increasing demand for the support of decision making and planning process in the state, national and global level.  From the Government sector, there is a need for spatial data to make quick responses to natural disasters, industrial accidents and environmental crises as actions will be decided based on geography. There is constant pressure to make wise decisions in a more time and cost effective and efficient manner. Accurate and current geospatial data are critical to these decisions.

1. Machine Learning

Learning denotes changes in a system that enable a system to do the same task more efficiently the next time (Simon, 1983)or Learning is constructing or modifying representations of what is being experienced (Ryszard Michalski et al., 1986). Machine learning is a scientific discipline concerned with the design and development of algorithms that allow computers to evolve behaviors based on empirical data, such as sensor data or databases. A learner can take advantage of examples (data) to capture characteristics of interest of their unknown underlying probability distribution. Data can be seen as examples that illustrate relations between observed variables. Discover new things or structure that is unknown to humanseg. data mining.A major focus of machine learning research is to automatically learn to recognize complex patterns and make intelligent decisions based on data.

Abstract
    
The amount of data being collected across a wide variety of fields today far exceeds our ability to reduce and analyze without the use of automated analysis techniques. In addition, the whole data may not be of user interest and imperfect. Therefore, it is very challenging to organize this data in formal system, which provides outputs in more relevant, useful, and structured manner. There are many techniques available to retrieve knowledge from this voluminous data. This paper discusses different rough computing based information retrieval techniques to obtain meaningful knowledge from large amount of datasets. We also discuss a real life example to show the viability of proposed research.

Abstract

Currently, computers are changing from single, isolated devices into entry points to a worldwide network of information exchange and business transactions called the World Wide Web (WWW).Current web contains billions of documents and has many administrative problems and limitations; in addition to that the web content is still accessible only to humans. For this reason, support in data, information, and knowledge exchange has become a key issue in current computer technology. The success of the WWW has made it increasingly difficult to find, access, present, and maintain the information required by a wide variety of users. In response to this problem, many new research initiatives and commercial enterprises have been set up to enrich available information with machine processable semantics.

Introduction

The role of knowledge management as the key source for competitive advantage in our organizations has become a hotly debated topic. Indeed, it is a core competency for creating competitive advantage. In this environment that knowledge management is vital, therefore, at first we should determine knowledge management situation, and then to achieve a desired point, formulate a knowledge management strategy.

Abstract

Cloud computing is becoming a technology mature enough for its use in genome research experiments. The use of large datasets, its highly demanding algorithms and the need for sudden computational resources, make large-scale sequencing experiments an attractive test-case for cloud computing. So far I have seen cloud computing demonstrated using R. However, it remains to be seen a rigorous comparison of its performance using a BLAST search and its ability to cope with ever-increasing databases and open source frameworks such as bioperl or bioconductor.

“Knowledge Management is the process by which an organization identifies, creates, manages and delivers information to enhance workforce performance. The purpose of knowledge management is to provide information collected from employees, best practices, clients, competitors and other sources in a format that employees can use to the productivity and quality of their work”

Before attempting to address the question of knowledge management, it’s probably appropriate to develop some perspective regarding this stuff called knowledge. Consider this observation made by Neil Fleming [1996] as a basis for thought relating to the following points.

Now days, in every walk of our life, we deal with a lot of information. It can be for personal use or family matters or for official or business matters. We store, process and retrieve variety of information. Information is basically the collection of various facts, records, statistics, formula or methods, which we use for our official work, for our research or for other use. When all these (information, we keep/ accumulate, for possible future use) are put in an organized manner, we find it convenient to use and easy to remember/ apply. Today, as it is rightly said, information is power; information is our knowledge-strength. It is thus important to organize and manage this knowledge that mostly depends on (and derived from) an information pool.

Introduction

Individual bits or “bytes” of “raw” biological data (e.g. the number of individual plants of a given species at a given location) do not by themselves inform the human mind. However, drawing various data together within an appropriate context yields information that may be useful (e.g. the distribution and abundance of the plant species at various points in space and time). In turn, this information helps foster the quality of knowing (e.g. whether the plant species is increasing or decreasing in distribution and abundance over space and time). Knowledge and experience blend to become wisdom—the power of applying these attributes critically or practically to make decisions. This quotation is from the Atlantic Canada Conservation Data Centre, a non-profit organization established in 1999.Thus, we are led to think about Data, Information, Knowledge, and Wisdom as we explore the capabilities and limitations of IT systems.

ABSTRACT

This paper presents few measures to be taken up by academic institutions, professional societies, industrial bodies and governmental agencies for the propagation of information of IPR in terms of encouragement of publication of books on IPR, establishment of IPR cells in academic and professional institutions and making IPR education as part of curriculum in Universities and institutions of higher learning.

ABSTRACT

This paper is an attempt to draw the attention of readers of this volume to understand the importance of documentation and preservation of earth’s resources.  

Introduction

Earth has innumerable treasures that were and are being exploited by mankind. Geo-resources in the form of minerals, non-renewable hydrocarbons, paleontologic relics and related evidences indicate earth’s evolutionary history. Continuum of biological activity albeit varying rates of proliferation had resulted in accumulation of natural resources embedded in Earth and distributed at specific geographical niches. Biological perspective of earth history is significant in unraveling bio-geo-sphere interactions through geological time. Fossil records of invertebrates, vertebrates and plants are signals of major changes in earth’s evolutionary history. These constitute unparalleled windows to understand continental separation. Intercontinental and intra continental migration of living forms are also traced through fossil study.

ABSTRACT

The concept and nature of intellectual property have undergone a paradigm shift during the last few decades. The importance of effective IPR governance has attracted the attention of its stakeholders. Hence, this paper focuses on the role of IPR governance and management practices for improving the quality of relationships among stakeholders besides documenting current and future trends of IPR governance and management.

INTELLECTUAL PROPERTY RIGHTS – AN INTRODUCTION

Intellectual property rights refer to the privileges granted by the government to any individual or organization for creative prowess. In recent years, such rights have gained immense importance. The laws in existence for protection and enforcement of these rights are meant to foster innovation and for regulating the use of inventions.

ABSTRACT

This paper discusses IPR concepts in the light of Indian culture and issues emanating from enforcement of those concepts in developing countries such as India.

INTRODUCTION

The adage “Knowledge is wealth” suits the present era well than any other period. India is known for its innovative thoughts since ages. However, it never monopolized the knowledge it possessed. In India, the knowledge of a person is thought to be utilized for the benefit of the society as an obligation of the knowledge holder. Does this mindset of Universal humanity (Vasudevo Kudumbagam) and common good (Sarva Sugino Bavandu) would benefit us in the materialistic society? This paper is an attempt to answer this query.

ABSTRACT

This paper is an attempt to analyze the plausible impacts on the economy and social issues of developing countries with reference to enforcement of IPR.

Introduction

From commodity based nature, business has changed during the past hundred years in a way that ideas and knowledge have taken higher value than commodities. Today, many companies find their most valuable assets being intangible and they are therefore dependent on functioning IPR systems. But does the rigid protection of IPR serve all the people in our globalized world? The purpose of this paper is to discuss the impact of the introduction of IPR protection on developing and under developed countries in the light of TRIPS Agreement.

ABSTRACT

This paper attempts to portray prevailing scenario of IPR in the light of globalization with special emphasis on harmonization of IPR systems and laws of different countries. 

INTRODUCTION

The globalization of information, facilitated by the Internet, has significant implications for intellectual property regimes of national and international levels. Assessment of these implications and their probable outcomes is unavoidably value-driven. Globalization represents ever-increasing influence of developed nations and transnational entities over developing and less developed nations. The process has also brought in significant changes in understandings of sovergenity. An analysis of the implications of globalization of information on international and domestic intellectual property rights and legal regimes is a complex endeavor.

ABSTRACT

This paper takes cues from the previous paper on the evolution of IPR concepts and attempts explaining the nuggets of TRIPS and analyzes the current trends in its implementation.

Introduction

As the TRIPS Agreement signifies stronger protection of conventional and new areas of intellectual property, the question that how implementation of TRIPS could influence developed and developing countries is to be addressed. The implications of such influence have far reaching consequences in terms of socio-economic development of Nation States, including geopolitical strategies and hence, a proper understanding on the plausible influence is essential.

ABSTRACT

This paper provides an account on the origin of the concepts of IP, gradual development and their culmination at the TRIPS.

Introduction

Intellectual property rights form the most prominent and ever-expanding category of rights in the 21^st Century. It differs from other proprietary rights in many respects and prevails in most articles of law, which influence our daily life. The economic significance of intellectual property rights has made it a subject of global political interest. In the broader sense, the term “intellectual property rights” connotes different categories of rights such as patents, copyrights, trademarks, designs, plant varieties, semiconductors, geographical indications, trade secrets and data exclusivity with varying scope

ABSTRACT

This paper provides an overall view on the history, structure and functions of World Intellectual Property Rights Organization.

Introduction

Human genius is the source of all works of art and invention. These works are the guarantees of a life worthy of men.  It is duty of the state to ensure with diligence the protection of the arts and inventions,” reads an inscription on the copula in the WIPO Headquarters building in Geneva. True to this inscription, WIPO functions through various mechanisms fostering judicious utilization of human intellect.  This paper intends presenting an overview on WIPO.

Abstract

Intellectual property right (IPR) is the most serious, new branch of law and a legal right conferred by federal government in accordance with International conventions and treaties. IPR protects some of the finer manifestations of human achievement. IPR safeguards the application of ideas and information that are of commercial value. The exploitable ideas become more sophisticated and hope for a successful economic future depends increasingly upon the superior corpus of new knowledge and fashionable conceits.  Copyright law is one of the effective tools of IPR. Copyright law provides an incentive to creative activity of author and permits the society to benefit from those inventions. However, the technological advancement has made violation of copyright very easy and regulation very difficult. This paper aims at familiarizing  copyright laws and the powers enshrined in copyright laws.

ABSTRACT

This paper presents an outline on the patenting system prevailing in India. 

INTRODUCTION

Ideas and knowledge are increasingly important parts of trade. Most of the value of new medicines and other high technology products lies in the amount of invention, innovation, research, design and testing involved. Hence, protection of such values is paramount. This paper details how these values are protected in India.

ABSTRACT

This paper provides an overview on existing IP protection and registration systems of India and adds information culled from publicly available sources pertaining to modernization efforts of Government of India towards establishment of foolproof IP protection in accordance with international treaties, conventions and bilateral and multilateral agreements.

ABSTRACT

The law of intellectual property has assumed utmost importance the World over, in the recent past and it is being considered as one of the most important subjects of law in view of its implications on economic, social and cultural realms. The term “intellectual property” has come to be internationally recognized as covering, patents, industrial designs, copyrights, trademarks, know-how and confidential information or trade secrets. This paper presents an overview on nature and scope of these elements of IPR.

ABSTRACT

Concomitant with paradigm shift from agrarian and brick and mortar economy to knowledge and service based economy, India needs to adhere to the international conventions for the benefit of enriching its knowledgebase with which economic development and social welfare could be achieved. Although geoscientific research has been at the forefront and contributed immensely to our country’s economic development, number of applications for patents, copyrights, etc., on geoscientific concepts, databases, innovations, designs or processes has been negligible when compared with other branches of science. This paper intends drawing the attention of geoscientists on this lacuna and provides information on fundamental aspects of IPR that may be of help to geoscientists whose innovations are waiting to be filed for patents or copyright.

In factorial experiment it may sometime happen that certain factors require bigger plots than other for convenience of operation of the experiment.  For example, in an agricultural experiment involving two factors, say, irrigation and fertilizer, it is organizationally very inconvenient to apply different levels of irrigation to small neighbouring plots.  But there is no such difficulty for the application of different levels of fertilizer. To meet such situations it is desirable to have different sizes of the experimental units in the same experiment.

In the foregoing experiments performed either in CRD or RBD or LSD. We were primarily concerned with the comparison and estimation of the effects of a single set of treatments like varieties of paddy, different methods of cultivation etc., and such experiments which deal with one factor only may be called simple experiments. In factorial experiment the effects of several factors of variation are studied and investigated simultaneously in a single experiment, such experiments are known as factorial experiments. In these experiments an attempt is made to estimate the effects of each factors and also the interaction effects i.e. the variation in the effect of one factor as a result to different levels of other factors.  These experiments provide an opportunity to study not only the individual effects of each factor but also interactions.  In many biological and clinical trials factors are likely to have interaction. Therefore, factorial experiments are more informative in such investigations.

In many situations, experiments may not known in advance which contrasts they wish to compare, or they may be interested in more than (m – 1) possible comparisons.  In many exploratory experiments, the comparisons of interest are fixed only after preliminary examinations of the data.
 
13.1 Scheffe’s Method for Comparing All Contrasts

Scheffe (1953) has proposed a method for comparing any all possible contrasts between treatment means.  In the Scheffe method, the type I error is at most a for any of the possible comparisons.

12.1 Introduction
 
The design of the experiment includes (i) planning of the experiment (ii) obtaining the relevant information from it regarding the statistical hypothesis under study and (iii) making a statistical analysis of the data. Design of experiment may be defined as the logical construction of the experiment in which the degree of the uncertainty with which the inference is drawn may be well defined. It may also be redefined as the choice of treatments, the method of assigning treatments to experimental units and arrangement of experimental units in varies patterns to suit the requirement of particular problems, are combined known as the design of experiment.

11.1 Introduction

The analysis of variance is a powerful statistical tool for tests of significance.  The test of significance based on t-distribution is an adequate procedure only for testing the significance of the difference between two sample means. In a situation when we have three or more samples to consider at a time an alternative procedure is needed for testing the hypothesis that all the samples are drawn from the same population, i.e., they have the same mean. For example five fertilizers are applied of four plots each of wheat and yield of wheat on each of the plot is given we may be interested in finding out whether the effect of these fertilizers on the yields is significantly different or in other words, whether the samples have come from the same normal population. The answer to this problem is provided by the technique of analysis of variance. Thus basic purpose of the analysis of variance is to test the homogeneity of several means.

10.1 Introduction

In previous lessons we have been dealing with problems connected with variation occurring in any one variable, say the income of a person, the height or weight of an individual, the wage of a worker in a factory, the sales of a shop, demand of a commodity etc.  The values of a single variable were obtained from every member of the population and the different characteristics were described by certain descriptive constants after grouping into frequency distribution.  In this lesson, we shall be dealing with problems wherein there are paired variables and every individual or member of the population exhibits two values, one for each of the variables under consideration.  Example of the two variables which are to be studies together are (i) the income and expenditure of a household, (ii) the price and demand or supply of a commodity, (iii) the height and weight of a student, and (iv) the grain yield and straw yield of paddy, (v) Height of father and height of son, etc.

We have seen the procedures of testing hypothesis about population parameters in chapter 11. Frequently our interest is to test whether a set of observed values are in agreement with those which would occur if some specified hypothesis were true. The X² statistic provides a measure of agreement between such observed and expected frequencies.

The X² distribution has a number of applications in testing of hypotheses. It is used to test, (1) the independence of attributes, (2) the  goodness of fit, (3) the homogeneity of variances, (4) the homogeneity of correlation coefficients, and (5) the linkage in genetic problems. For applying X² test procedure we have to use only the actual observed frequencies and not the percentages or ratios. Further, the samples should be independent and the observations within a sample should be non-overlapping. The expected frequency in each category should be more than 5. The number of observations should be large, say, more than 50.

8.1 Statistical Hypotheses

in attempting to reach decisions about the populations, it is useful to make assumptions or guesses about the populations involved. When the assumption or statement about a phenomenon occurring under certain conditions is formulated as proposition it is called a scientific hypotesis. We can construct criteria by which a scientific hypothesis may be ‘the  yield of a new paddy variety will be 3500 kg per hectare’. In statistical language it may be stated as ‘the random variable (yield of paddy) is distributed normally with mean 3500 kg/ha’. Such a statement or proposition about the probability distribution of a random variable is called the statistical hypothesis.

7.1 Meaning of Sampling
    
Before we consider sampling theory, we first define the terms population and sample.
 
The word ‘population’ or ‘universe’ in statistics is used to refer to any collection of individuals or of their attributes or of results of operations which can be numerically specified. For example the assemblage of heights of all the individuals in the population is called a population of heights.  Similarly we may consider the population of weights, wages, yields of grain; prices of wheat, mileages of automobile tyres, etc. a population containing a finite number of individuals or members is called a finite population.  For instance the population f ages of the workers in a factory constitute a finite population of ages. A population with infinite number of members is known as infinite population.  For example the population of pressures of temperatures at various points in the atmosphere is an infinite population. 

It has been a general notion that if an experiment is conducted under identical conditions, values so obtained would be similar. But the experiences of people have dispelled this belief. Observations are always taken about a factor or character under study, which can take different values, and the factor or character is termed as variable.
Hence, we have a set of outcomes (sample points) of a random experiment. A rule that assigns a real number to each outcome (sample points) is called random variable. The rule is nothing about a function of the variable, say, X, that assigns a unique value to each sample point of the sample space.

In day-to-day life, one comes across many statements which create doubt about certain happenings and one may want to determine the chance of occurrence of a particular happening, e.g., if one desires to know the chance of rain based on some metrological observations.  In the case of coin tossing, one wants to know what will be the chance of winning if a person always stakes for head in a fixed number of tossing. There can be innumerable such queries which one would like to make and meanwhile evaluate mathematically the chance of the occurrence of such possibilities.  This invoked the need of probability theory. The theory of probability came in existence when problems of games were referred to mathematicians like Karl Pearson, Laplace and others. Complicated applications involving advanced theory of probability and axionmatic approach of probability are not dealt within this book.

4.1 Introduction and Measuring

A measure of central tendency exhibits only one of the important characteristics of distribution, namely they typical representative figure to the whole set of its values. This measure alone will not adequately describe a set of observation unless all the observations are alike. Moreover one cannot understand completely about the data set with a measure of central tendency.  Because in real practical situation there may exits a number of sets of observations (or different distributions) whose measures of central tendency are same but they may differ individually from each other in a number of ways.  In particular two sets of values have the same mean but whilst one set of data is grouped close to the mean the other one is more spread out.  The following examples will illustrate this view point clearly.

3.1 Introduction

One of the most important objectives of statistical analysis is to summaries the information contained in the data which may be considered either as a population or as a sample (or sub-population). If the set of data consists of all conceivably possible (or hypothetically possible) observations of a certain phenomenon or a variable, we call it as population. If a set of data contains only a part of these observations, that is selected values of a variable, we call it as sample. Frequency distribution and graphical representation summarize to some extent.  They reduce a mass of data to a more understandable form but not to a single value. The aim of this lesson is to determine descriptive measures or statistical constants which will describe the nature of the data.

2.1 Quantitative Classification

It the data are classified on the basis of phenomenon which is capable of quantitative measurement like age, height, weight, prices, production, income expenditure, sales, profits, etc., it is termed as quantitative classification. The quantitative phenomenon under study is known as variable.  For example the daily incomes of different retail shops in a town may be classified as under.

1.1 Definition of Statistics

Statistics has been defined differently by different ‘Statisticians’ from time to time. These definitions emphasize precisely the meaning, scope and limitations of the subject.  The reasons for such a variety definitions may be stated as follows:

    i.    The field of utility of statistics has been increasing steadily and
    ii.    The word statistics has been used to give different meanings in singular (the science of statistical methods) and plural (numerical set of data) senses.

In order to have a clear grasp of the subject, we give below some selected definitions of statistics which are grouped under two main heads: ‘Statistics as numerical data’ and ‘Statistics as Methods’.  The former one is in plural sense and the latter singular sense.