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In the past, there was no targeted development of biomaterial based on scientific criteria. Instead devices consisting of material that had been designed, synthesized and fabricated for various industrial needs (the textile, aerospace, and defense industries) were tested in a trial and error fashion in the bodies of humans and animals. These unplanned and sporadic attempts had modest success. Most frequently, the results were unpredictable, mixed, and confounding both in success and in failure. In addition to traditional medical devices, diagnostic products, pharmaceutical preparations and healthcare disposables, now the list of biomaterial application includes smart delivery systems for drugs, tissue cultures, engineered tissues and hybrid organs. Undoubtedly biomaterial have had major impact on the practice of contemporary medicine and patient care in both saving and improving the quality of lives of the humans and animals4.

Health care is an important way of making sure that rabbits stay productive. Every rabbit keeper should know how to recognize and, if possible, prevent and cure illnesses which can affect rabbits.

It is always better to prevent disease incidence than to let animals get ill and then try to treat them. Allowing rabbits to get sick is expensive for several reasons, sick animals stops growing and reproducing so money is lost with this decrease in production, some disease results in the death of rabbits, replacing the dead rabbits is expensive , treatment for the ill rabbits is usually expensive.

Introduction

In agriculture, plant diseases have always been a major problem, as they cause crop quality to decrease, resulting in yield. Plant disease has a range of effects from minor symptoms to serious damages in whole crop areas, which lead to high financial costs and significantly impact the agricultural economy, particularly in developing countries dependent on a single crop or on a few crops.

Various approaches have been developed to detect disease in order to avoid significant losses. Causal agents have been precisely defined by methods developed in molecular biology and immunology. However, for many farmers these techniques are inaccessible and require detailed knowledge of the field or substantial time and energy to be used. According to the United Nations Food and Agriculture Organization, most farms in the world are small and family-owned in developed countries. Such families provide food for a significant proportion of the population of the planet. However, hunger and food insecurity are not rare and there is restricted access to markets and services. For the above reasons, a great deal of work has been undertaken in order to establish methods that are sufficiently reliable and available to most farmers. Where Plant disease is an essential factor contributing to a major decline in plant production quality and quantity. Plant disease identification and classification are a significant role in improving plant production and economic development.

Introduction

Most common improvement of host resistance to almost any pathogen is brought about by improving the genetic resistance of the host, that is by breeding and using resistance varieties.

Genetic engineering technology made possible the isolation of individual resistance (R) genes from resistant plants and the transfer of such genes into susceptible plants in which they induce the hypersensitive resistant response.

Thus, genetic engineering technology combined with Conventional plant breeding, will provide one of the most effective tools for controlling plant diseases.

Introduction

Food is the most basic necessity for man. Plants are primary producers of food. Plants are the very pivot of our existence on earth and without plants the earth would be without life. The success or failure of crop production relies on interaction among varieties/genotypes, inputs used, environment and management factors. Plant diseases caused by fungi, bacteria, viruses, phytoplasmas and nematodes reduce crop yields (Khoury and Makkouk, 2010). Arid fruit crops like ber, aonla, date palm, pomegranate and vegetables like watermelon/mateera, kachri, snapmelon, muskmelon, ridge gourd and sponge gourd are mostly grown in Central and Western India. Horticultural crops can be infected by wilt, leaf spots (due to excessive moisture), mosaic and post harvest fruit rots. These diseases are major challenges in the cultivation of horticultural crops in India. Disease incidence in a crop is governed with the seed materials used and environment surrounding seed/plant.

A management tool for anticipating the onset of diseases in plants is called plant disease forecasting. This management method makes use of data on the past, present, and predicted weather in a particular area to forecast the onset and severity of disease in the future. In this sense, a plant disease forecasting system notifies farmers ahead of time whether or not to modify their crop protection strategies to ward against pests. The disease forecasting method lowers financial costs, farmer production loss, and negative environmental effects when it is timely and precisely forecasted. These systems ought to be prepared for diseases like these, which don’t happen often but rather manifest destructively during opportune weather.

Requirements for Disease Forecasting

Systems for forecasting plant diseases are based on the “disease triangle,” which describes how the environment, host, and pathogen interact. Therefore, information on these variables is necessary for the accurate forecasting of a disease outbreak in the future. Following questions and answers cover various aspects of disease forecasting and pathometry, including their impact on integrated disease management, environmental considerations, and specific challenges in different agricultural settings.

Abstract

Climate change is a long-term change in the statistical distribution of weather patterns over periods of time that range from decades to millions of years. It may be a change in the average weather conditions or a change in the distribution of weather events with respect to an average. Climate change may be limited to a specific region, or may occur across the whole Earth.Since, time immemorial human beings have attempted to predict the disease occurrence informally by mere observing the changes in pattern of weather parameters. But the present scenario has been very much altered with the incessant and irrational use of natural resources exposing the atmosphere to the enormous encumbrance. Excessive CO₂ emissions, deforestation and injudicious use of chemicals in agricultural fields have ultimately led to the climate change, which needs an absolute engrossment. Climate change has also invited the emergence and resurgence of many of the pest and diseases posing a grave challenge to manage them. So there is a need for immediate action through Government policies and scientific community to combat the situation. Disease forecasting models may be one of the rescuing options to mitigate the problems of agriculture.

8.1 Disease Prevention and Control in Aquaculture

Aquaculture, the farming of aquatic organisms such as fish, shellfish, and plants, faces significant challenges related to disease management. Diseases in aquaculture can result from viral, bacterial, fungal, or parasitic pathogens, and their outbreaks can lead to substantial economic losses and environmental impacts. Effective disease prevention and control strategies are crucial to sustainably manage aquaculture operations and ensure the health and welfare of cultured species.

Key Strategies for Disease Prevention and Control

1. Biosecurity Measures

Biosecurity is foundational in preventing the introduction and spread of diseases within aquaculture facilities. It involves a set of management practices aimed at minimizing the risk of pathogen transmission through various pathways:

• Quarantine Protocols: New stocks should undergo quarantine periods before introduction to production systems. This allows for health screening and observation to detect and isolate potentially diseased individuals.

1. DISEASES OF MANGO

Mango is considered to be the king of fruit. India is the largest producer and exporter of mango in the world. Mango possess unique nutritional and medicinal qualities apart from being a rich source of vitamins A & C, besides its attractive form and appearance, delicious taste and appetizing flavor, the ripe mango fruit according to nutritional experts is also highly invigorating, fattening, laxative and diuretic. Every part of mango from root to tip is used in a variety of ways. This crop is affected by many fungal, bacterial and other non parasitic diseases.

1. Mango Malformation Disease (MMD)

Mango Malformation Disease is a fungal disease of mango caused by several species of Fusarium, some yet to be described. Mango is the only known host of the disease. The disease spreads on a tree very slowly, but if left unchecked, can severely reduce yields. The main method of spreading MMD to new areas is through infected vegetative planting material. There is no evidence that the disease can spread on fruit or the seeds, or that it affects human health. It usually associated with the bud mite, Aceria mangiferae but the mites have been shown to spread the disease within a tree and not between the trees. Mango malformation, also known as bunchy top, is a very serious threat to the mango industry, particularly in northern India. The Etiology of the disease still remains obscure and diverse claims have been made about its causes, e.g., physiological, viral, fungal, acarological and nutritional.

Importance of fruits in human diet is well recognized since time immemorial. They are important part of a healthy diet as natural sources of energy, essential vitamins, minerals and antioxidants ever since the beginning of humancivilization. Our country is bestowed with varied climatic conditions, which had made it possible to grow diverse group of fruits from its temperate to tropical, to subtropical and even to arid niches. The cultivation of fruit crops is, presently, one of the most important and profitable proposition. Growing fruit crops translate into realization of more yield/ income from a unit area of land than any of the agronomic crops. However, there is need to considerably increase the yield of fruit crops, particularly under changing environmental conditions as under such conditions diseases are getting more prevalent. Therefore by adoption of proper protection practices, yield of fruit crops can be improved.

Plant diseases caused by fungi, bacteria, viruses and phytoplasmas reduce crop yields (Khoury and Makkouk, 2010).Adoption and support for using participatory approaches help to farmers in disease management of fruit crops, reducing costs and improving production efficiency. Fungal, bacterial and viral diseases pose serious threat in the cultivation of fruit crops in India. To reduce the losses caused by plant disease, a complete knowledge of disease management strategies of fruit crops are essential which are as follows:

All lagomorphs (meaning ìhare-shapedî) are small to medium-sized terrestrial herbivores. They superficially resemble rodents and in older classifications were even included in the order Rodentia, as both possess a set of continuously growing incisor teeth. It is now recognized that these two orders have long separate evolutionary histories.

Wildlife diseases have gained some good momentum in the recent years due to the complex-linkage with zoonosis, conflicts between wild fauna and homo sapiens in an ascending manner, environmental health care measures etc. Due to this, considerable pressure is there on zoo veterinarians or the field veterinarians working in free ranging areas of forests like national parks, wildlife sanctuaries etc.

Resistance of some plants against a pathogen is due to their belonging to taxonomic groups which are outside the host range of the pathogen. Such resistance is called non host resistance. It is attributed either to genes for resistance (R genes) against the avirulence genes of the pathogen (true, race specific, cultivar-specific, or gene-for-gene type resistance), or to the plants escaping or tolerating pathogen infection due to various reasons (apparent resistance). There are two kinds of true resistance: partial (also called quantitative, polygenic, or horizontal resistance) and R gene resistance (also called race specific, monogenic, or vertical resistance). Several examples of true resistance attributable to, biochemical underpinning or genetic transformation of host plants of major fruit crops viz., apple, pear, apricot, plum, cherry, almond, mango, grapes, banana, citrus, papaya, guava and pomegranate against important plant pathogens are known. Much greater efforts need to be invested, however, for incorporating resistance to diseases in horticultural species because of their huge relevance to socio-economic well being of farming community of the hill regions. The effort in this chapter will be towards synthesizing information which officials of the administrative and development departments can use for drafting plans and policies for promoting protection and up gradation of livelihoods of hill farmers.

Abstract

Palms are generally grown commercially in tropical climate. But some of the palms like coconut, areca nut and palmyra palm are cultivated successfully in West Bengal, Orissa, Assam, and some pockets of Bihar that lies under sub tropics of India.Due to unsuitable climatic factor their production is more affected by abiotic and biotic stress including different kinds of diseases. The important disease are bud rot, basal stem end rot, nut shedding,stem bleeding in coconut, mahali disease, foot rot, stem breaking in arecanut and palmyra palm in the region have negligible incidence of diseases. These destructive diseases are the major constrain in production and causes severe yield loss in these palm fruits. Therefore effective management strategies are required by continuous monitoring the incidence and severity of these diseases caused by different pathogens.

Integrated disease management is the most accepted strategies for sustainable crop production that involves the holistic approach integrating cultural, physical, mechanical, chemical and biological means to control the disease. However, results of the disease management trials depend upon soil condition, age of the crop, stage of disease development and weather parameters of that particular area. Although it is impossible to manage a field free of pathogen but considerable reduction of the disease can be achieved through a proper integrated disease management system. Thus the causes and remedy of the diseases prevalent mainly in palms particularly in subtropical conditions has been reviewed for better management and sustainable production.

Types of Chemicals Used in Disease Management
1. Fungicides: Used to control fungal pathogens, fungicides can either prevent infection (protectant fungicides) or cure infections after they
occur (systemic fungicides). Examples include copper-based fungicides like copper oxychloride and sulfur-based compounds.
2. Bactericides: These are designed to control bacterial pathogens. Common examples include streptomycin and copper compounds, which act against bacterial blights and spots. However, bactericides are less widely used than fungicides due to limited availability of effective products.
3. Nematicides: These chemicals target nematodes, which cause root diseases in crops. Carbofuran & oxamyl are commonly used nematicides.
4. Fumigants: These are volatile chemicals applied to soil to kill a wide range of soil-borne pathogens, including fungi, bacteria, and nematodes. Examples include methyl bromide and chloropicrin.
Contact vs. Systemic Chemicals
1. Contact Pesticides: These chemicals remain on the surface of plants and must come into direct contact with pathogens to be effective. They are most effective as preventative measures.
2. Systemic Pesticides: These are absorbed by the plant and move through its tissues, offering protection from within. Systemic fungicides, such as triazoles, are curative, meaning they can halt an infection after it has started.

When a plant is unable to perform its functions normally, then it is diseased. The two major causes of disease in crops and trees are pathogens and environmental conditions. There are many kinds of disease pathogens: viruses, bacteria, fungi, nematodes, mycoplasma-like organisms, and parasitic higher plants. Fungal pathogens are the most common type. They cause seed rots, seedling damping-off, root rots, foliage diseases, cankers, vascular wilts, diebacks, galls and tumors, trunk rots, and decay of aging trees. Deterrents to establishment include unfavourable weather and environmental conditions such as Temperature and moisture extremes, high winds and ice may directly injure a tree and predispose the trees to pest attack.
Biodiversity plays multiple roles in development as well as ecological sustainability. It has received increased attention in agricultural ecosystems for the past few years regarding the reduction of plant diseases; however, the knowledge of using biodiversity to manage plant diseases is Still incomplete. For crop diversification, the interaction of genetic diversity per se in host populations with identifiable resistance and other functional traits of component genotypes to mitigate disease epidemics is not well understood, and neither is the best way of structuring mixed populations. The mixing of crop varieties can significantly reduce disease epidemics in the field. To achieve the best disease mitigation, growers should include as many varieties as possible in mixtures or, if only two component mixtures are possible. The many strategies, tactics, and techniques used in disease management can be grouped under very broad principles of action. The differences between these principles are often not clear. The simplest system consists of two principles, prevention (prophylaxis in some early writings) and therapy (treatment or cure). The first principle (prevention) has to do with disease management practices applied before infection-that is, the plant is protected from disease.

Abstract

The disease is an output of the interaction among host, pathogen, and the environment over a period of time. Given that a susceptible host and an aggressive pathogen are available, weather determines the intensity of the disease over time. To capture the dynamics of the interactions among these biophysical variables, efforts have been made in the past to understand the variables per se and their interactions through modeling approaches.  The important weather parameters are temperature; rainfall/dew; leaf wetness period, wind, bright sunshine hours all of which are in turn influenced by soil properties. The important parameters of host that can influence disease development are susceptibility; growth stage and form; structure and density of the plant population and overall health. For pathogen, to cause disease, it should be present in the vicinity, pathogenic, adaptable with reproductive fitness and possess efficiency of survival and dispersal. 

Introduction
Vegetable crops are highly susceptible to biotic stresses indicated by disease causing micro-organism (fungi, bacteria, virus and phytoplasma). Indiscriminate use of chemicals for the control of diseases, insect pest have
several disadvantages, particularly increased cost of cultivation, residual toxicity in food chain and development of resistance against pathogen. Management of diseases involves use of resistant varieties and integration of cultural and chemical control measures. Of the biotic stresses much of the breeding efforts have been directed towards developing resistance against diseases. In fact, breeding for resistance, has been one of the most important objective of vegetable breeder in the last half of the century. Genes that contribute to pathogen tolerance/resistance can be obtained from local germplasm resources, or through exotic lines, wild species or genera, or lines from other breedingprograms. In the biotechnological approaches for vegetable breeding also,  most of the achievement has been to generate transgenic plants resistance to disease. Often breeding for resistance has assumed greater importance in a number of vegetable crops.
Major Diseases of Tomato
Early blight: The casual organism is Alternaria solani. The symptoms appears as small, black spots with enlarged and concentric rings in a bull’s eye pattern in the center of the leaves. Tissue surrounding the spots may turn yellow. On fruits, dark brown concentric rings are seen that affects the market quality.

The disease , referred as the disorder of crop plants caused by fungi, mycoplasma, bacteria and viruses. Plant resistance is one of the most effective and ideal approach to combat diseases and insect-pest. Resistance is the capacity of plants to resist, withstand and overcome the attack of pathotypes.

Mechanism of Disease Resistance

Different mechanism of disease resistance are as under:

1. Disease escape

The ability of susceptible host plants to avoid attack of disease due to environmental factors like early maturing varieties, shift in the date of planting, change the field, balanced application of NPK etc. Example., early maturing varieties of groundnut and potato may escape from ‘Tikka’ and ‘Late blight’ diseases respectively.

2. Disease tolerance

The ability of the plants to tolerate the attack of the pathogen without loss or little loss in the yield. This endurance is brought about by the influence of external characters. Generally, tolerance is difficult to measure since it is confounded with partial resistance and disease escape. Disease tolerance is of three types:

Climate change in particular global warming affect the health of the animals both directly and indirectly. Direct effects include temperature associated diseases like heat stroke and death and morbidity of animals during extreme weather conditions. Indirect effects include those deriving from attempt to adapt to changing environment or influence of climate on microbial populations, distribution of vector borne diseases, host resistance to infectious agents, feed and water shortages or food borne diseases. Among infectious diseases vector borne diseases and diseases caused by agents who have a stage in the environment are more likely to be affected than other diseases. The assessment of impact of climate change on animal diseases is challenging because there are several factors affecting the disease dynamics. But once the risk of potential diseases and their transmission routes are identified, the disease forecasts can be generated and control measures can be implemented to reduce the risk of such diseases.