eChapters

Introduction

Microencapsulation is a process of entrapping solid particles, liquid droplets or gases in thin polymeric coatings. The outer film (wall) protects the encapsulated material (core) and allows for its controlled release. Application of this technique is wide spread in several industrial fields, including the manufacture of foods, pharmaceuticals, cosmetics and pesticides. Common food ingredients subjected to microencapsulation include probiotic bacteria, acidulates, flavours, colours, sweeteners, minerals and vitamins. A number of coating materials are employed in production of microcapsules, such as gums, starch, and starch derivatives, cellulosic materials, lipids, proteins and inorganic materials.

Actually the development of the formation of micro-encapsulates was partially inspired by the nature. Eggs, seeds, grains, nuts, fruits etc. are typical examples of the food encapsulation and natures own way of conserving and protecting natural products against its own deteriorating elements. Taking clue from this, man adopted this technology of protection of some of the foodstuffs as sauces, puddings etc. Microencapsulation can improve the convenience of food. The shell provides a barrier between reactive components (for instance, delaying the release of leavening agents for fluffier bread products or protecting oxygen-sensitive materials during processing and storage). Microcapsules can help fragile and sensitive materials survive processing and packaging conditions and stabilize the shelf-life of the active ingredient.Karel (1994) described various methods of encapsulation of food ingredients.Inaddition, microencapsulation can simplify the food manufacturing process by converting liquids to solid powder, decreasing production costs by allowing batch processing using low-cost, powder-handling equipment. To improve food safety, the technology can be used to indicate product tampering, thermal spoilage, and freeze-thaw cycles.

Probiotics have been newly defined as ‘live microbes which passage the gastrointestinal tract and in doing so benefit the health of the consumer differing from the earlier definitions which focused on probiotic interfaces with original intestinal microbes (Fuller, 1989). These definitions of probiotic bacteria generally agree that probiotic bacteria should be living organisms toward consult health benefits. Probiotics have been reported to play a therapeutic role by modulating immunity, lowering cholesterol, improving lactose tolerance and preventing some cancers (Kailasapathy and Chin, 2000).

This chapter introduces the major textile and non-textile applications of wool and relates end-use requirements to fibre properties. It examines apparel, carpets, blankets, upholstery, knitting products, interiors and technical textiles. The chapter considers how fineness, length, strength, crimp, colour, resilience and thermal behaviour influence product selection. It also highlights the continuing importance of wool in premium and specialized markets and explains how processing technology enables wool to meet different performance and design requirements.

ABSTRACT

In Ayurvedic system of medicine, the word Astavarga represents eight endangered Himalayan herbs, which includes four orchids Habenaria intermedia D.Don, Platanthera edgeworthii Hook.f., Crepidium acuminatum D.Don, Malaxis muscifera Lindl., three liliaceae members (Lilium polyphyllum D.Don, Polygonatum verticillatum L.,Polygonatum cirrhifolium Wall.) and one zingiber (Roscoea purpurea Sm.). These herbs are popular in various ayurvedic formulations, as for instance, Chyawanprash which is well recognized for strengthening vital force to the body, help in cell regeneration, and build immune system. These plants are repository of various bioactive ingredients such as diosgenin, β-sitosterol, catechin, p-coumaric acid and many more which shows positive biological functions such as anti-microbial, anti-oxidant, antiinflammatory and other associated health promoting activities. In traditional system, different parts of these plants are used for different purpose, and mainly rhizomes are used as herbal formulations. In terms of ecology, these plants are growing wild in Himalaya belts between the elevation ranges of 1200-4000m above mean sea level. Subtropical, temperate and alpine environment provide condusive adaptation and habitat for these species to grow and florish. Due to lack of proper documentation and certification, the identification of most of the species became difficult and illusory. Considering the medicinal importance and endangerment status, attempts have been made in the present communication to provide a comprehensive account on phytochemistry and pharmacological activities associated with astavarga species. The data presented in this communication will put door open for various research activities related to discovery of new drugs and nutraceutical products for human welfare in days to come.

Using the FAO criteria, Bargur and Siri cattle breeds and Attapadi goat breeds were categorized under vulnerable status of risk; Krishna Valley, Mewati, Pullikulam and Punganur cattle breeds, Chilika and Toda buffalo breeds and Karnah and Poonchi sheep breeds under endangered status of under risk and Vechur cattle under critical status of risk. All these breeds need immediate steps for rescue by using suitable conservation methodology. Breed-wise census should be continued in future so that trends in breed populations may also be estimated for fine tuning of risk assessment of breeds.

Rate of inbreeding in Indian livestock breeds: The rate of inbreeding estimated for different breeds of cattle was well below 0.5% (needed for a breed ‘not at risk’) except for Mewati (1.193%), Pullikulam (0.72%) and Vechur (17.893%). The rate of inbreeding in buffalo breeds was also well below 0.5% except in Chilika buffalo, where it was 0.731%. The rate of inbreeding of these breeds may be reduced by increasing the number of breeding males and in Vechur also the breeding females. The rate of inbreeding in all the breeds of sheep (Indian or exotic), goat and pig were estimated to be less than 0.5%. In these species, a good balance of breeding males and females is always expected.

Introduction

Status of Tuberculosis : Tuberculosis is a complex and multispecies disease since the origin of human civilization. Evidence of tuberculosis (TB) exists in 3000 years old Egyptian mummies and about 17,000 year old fossilized bison (Fareed et al., 2024). Now, every year, 10 million people fall ill with tuberculosis. Out of 10 million people currently with new active TB, 1,40,000 (range, 69,800–235,000) are estimated to be new cases of zTB (1.4%) of which an approximately 11,400 (8.1%, range 4,470-21,600) died (WHO, 2020).Despite being a preventable and curable disease, 1.5 million people die from TB each year – making it the world’s top infectious killer (WHO, 2023). Disease is still in an increasing scenario as evident that in 2018, an estimated 10 million people fell ill with TB and 1.5 million died of the disease whereas in 2021 there were an estimated 10.6 million new cases of TB and 1.6 million TB deaths (Ayalew et al., 2023). COVID-19 has further increased the projection of TB and increased the expected case number. As it is predicted that between 2020-2050, 31.8 million will have died of TB, More than half million cases of TB annually are classified as drug resistant, as a result, TB is becoming more difficult to diagnose and treat.

1. Prosthogonimus pellucidus is found in

a) Fowl

b) Duck

c) Both

d) None

2. Heterakis gallinarum is found in

a) Fowl

b) Pea fowl

c) Guinea fowl

d) All

Endocrine glands are organs which secrete chemical substances called hormones into the blood stream. Hormones are substances produced by specific glands, secreted directly into the blood and transported to various organs and tissues where they exert their effects. The term hormone is derived from the Greek root meaning to excite. The organs/cells where there hormones bring about their actions are called target organs/cells. The target organs (hormone binding receptors) posses specific receptors for bringing about the action of these substances. The term neurosecretion signifies the production and reiose of hormones by nerve cells that have the cytological characteristics of secretory cells.

Several hormones are the product of nervous mechanisms hence the term neurosecretion is used and neurohumour for such substances.

Hormones act as a mode of transmitting information in the body in addition to the nervous system. Their mode of action is slow but more prolonged. Chemically the hormones are either proteins or steroids. Hormones are secreted in very small amount but their actions are profound. Early investigators were hampered by the non availability of suitable methods for their estimation. The availability of radioimmunoassay, radio-receptor assay, enzyme linked immunological assay have greatly facilitates researches in the field of endocrinology.

The mode of action of these hormones has been elucidated in several instances. Involvement of membrane permeability and cyclic AMP has been implicated in several cases.

Most of these hormones have been of therapeutic interest for several decades. The mode of administration of steroid hormones can be both oral or parenteral while protein hormones are active only when injected. Several of these hormones are used for increasing the production potential of meat animal, for improving the reproductive efficiency of domestic animal, hence are of direct economic importance to the farmers. Chemical characterization and their synthesis including their more potent analogues in several cases, have greatly facilitated their widespread application in the animal production and animal health strategies.

Endocrinology is the study of the structure and function of the endocrine glands and their secretory products, including the consequences of excessive or deficient production of these hormones.

Pituitary gland (Hypophysis cerebi)

The pituitary gland (hypophysis cerebri) lies at the base of the skull and is housed within a bony structure called the sella turcica in the body of the besisphenoid bone. It is a small pea shaped gland which is attached to the hypothalamus by the pituitary stalk. The pituitary gland has two distinct parts called the lobes. These are the anterior lobe (adenohypophysis) and the posterior lobe (neurohypophysis). The anterior lobe which is also called as anterior pituitary consists of five types of cells, each of which secretes different hormone or hormones. The types of cells, the hormones secreted by each type and the functions performed by them are narrated below.

The thyrotrophs secrete thyroxin called as Thyroid Stimulating Hormone (TSH). It stimulates production of thyroid hormone.

The gonadotrophs secrete leuteinizing hormone (LH) and Follicle Stimulating Hormone (FSH). The LH stimulates the production of oestrogen and progesterone by the ovaries in female and testosterone by the testes in male. The FSH stimulates the production of oestrogen and the growth of egg cells (oocytes) in the ovaries in female and sperm cells (spermatozoa) in the testes in male.

The corticotrophs secrete the Adreno-Cortico-Trophic Hormone (ACTH) which stimulates the production of cortisol and adrenogenic hormones by the adrenal cortex.

The somatotrophs secret Growth Hormone (GH). The GH is a growth promoting hormone which regulates the growth and differentiation of the skeletal system.

The lactotrophs secrete the Prolactine Hormone. The prolactine hormone is responsible for initiation of milk secretion by the acinar cells of the mammary gland.

The defined endocrine glands include the pituitary gland, the pineal gland, the adrenal glands, the thyroid gland and the parathyroid glands. The organs which contain groups of endocrine cells include the pancreas, the testis, ovary and placenta. The Hassall's corpuscles of thymus secrete hormone which contributes to the maturation of T-lymphocytes. Hence the thymus can be considered as having an endocrine function.

Pituitary : Refer to Part II, Chapter 2

Thyroid gland : Refer to Part II, Chapter 2

Pineal gland (Epiphysis cerebri) : Develops as a dorsal neuro epithelial diverticulum of the caudal part of the roof of the diencephalon. After its formation the gland remains attached to the diencephalon by a stalk. The neuroepithelial cells differentiate into pinealocytes and glial cells. The developing gland is surrounded by a thin layer of piamater.

Pituitary gland

The pituitary gland (hypophysis) lies at the base of the skull and is housed within a bony structure called the sella turcica in the body of the basisphenoid bone. It is a small pea shaped gland which is attached to the hypothalamus by the pituitary stalk. The pituitary gland has two distinct parts called the lobes. These are the anterior lobe (adenohypophysis) and the posterior lobe (neurohypophysis). The anterior lobe which is also called as anterior pituitary consists of five types of cells, each of which secretes different hormone or hormones. The types of cells, the hormones secreted by each type and the functions performed by them are narrated below.

Healing of fracture is a consequence of cellular behaviour in a living organism and as such can be modified by almost all endogenous or exogenous factors that affect the metabolic function of cells. These factors include transforming growth factor-β, bone morphogenetic proteins, hormones, vitamins and prostaglandins. The anabolic hormones like thyroxine and insulin accelerate bone formation in experimental animal. Hence, this chapter is proposed to evaluate the effects of thyroxine and insulin therapy in the management of tibial metaphyseal fracture in dogs.

Clinically healthy, adult mongrel dogs (15) of either sex are randomly divided into three groups (A₁, A₂ and A₃) of 5 animals each. In all the animals, unilateral metaphyseal fracture is created in the proximal tibia and then immobilized with cross intramedullary pinning with interfragmentary wiring under thiopental (5%) anaesthesia. All the animals are administered broad-spectrum antibiotic (streptopenicillin @ 1 g intramuscularly /dog/day) and analgesic (5 ml I/M daily) and surgical wounds are dressed daily with Povidone iodine and Lorexane cream for 5 days postoperatively. In group A₂, thyroxine sodium tablets (0.013 mg/kg body wt, orally) and in A₃, insulin injection (2 IU/kg body wt, s/c) are given on day 7 and then on every alternate day till day 45 postoperatively, at one specific time. Group A₁, is remained as control, in this group no hormonal therapy is given.

Craniocaudal and mediolateral radiographs of the fracture site are taken immediately after surgery and subsequent on days 15, 30, 45 and 60 postoperatively. The radiographs are observed for status of fracture reduction and fixation immediately after surgery and subsequently for the maintenance of reduction, progress of fracture healing and complication, if any, at different intervals.

Endocrine glands secrete their products into the bloodstream and body tissues in conjunction with the central nervous system to control and regulate a variety of body functions (Fig. 26.1). Various endocrine glands described below have been discovered in fish that are associated with various tasks and functions.

26.1 Pituitary Gland

26.1.1 Introduction

The pituitary gland (=Hypophysis) is a central and discrete organ of the neuro endocrine system in fish playing critical roles in various physiological processes such as stress response and behaviour.

Endocrine glands are organs which secrete chemical substances called hormones into the bloodstream. Hormones are chemical substances that are produced in one tissue, released into the bloodstream, and carried to other tissues, where they act through specific receptors to bring about changes in cellular activities. The term hormone is derived from the Greek root meaning to excite.

• In male animals, endocrine regulation of reproduction is mainly controlled by pituitary gonadotrophins and gonadal androgens. It is not the same as in females as there is only negative feedback controls in case of male while it is positively as well as negatively feedback control in females. In other words, the synchrony of pituitary gonadotrophins with gonads in male is non cyclic while in female it is cyclic i.e. even after castration (absence of androgen) the pulse frequency of LH and FSH is retained. • Sex Hormones are sex specific e.g. estrogen and progesterone work primarily in females and testosterone in males but sex specificity is limited as far as sexual behaviour is concerned. As estrogen injection in castrated ram recovers the maleness while testosterone injection in ovariectomized female maintain the receptivity for male up to a certain extent.

Introduction

Fruits play a vital role in improving human health which are called as protective foods rich in vitamins, minerals, fats, oils, proteins and improves in economy of producers, exporters and industrialists. Fruit crops can be classified into two broad categories i.e. ever green and deciduous trees.

1. Evergreen fruit trees grow under tropical and subtropical climate and they are not dependent on chilling requirement for floral bud differentiation and flowering. Ex: Mango, Citrus, Guava, Sapota, Papaya etc.,
2. Deciduous fruit trees require dormancy during winter season and chilling units for floral initiation and have specialized modifications to protect sensitive growing tissue from unfavourable conditions. Ex: Apple, Pear, Peach, Plum, Apricot, Cherry, Grapevine, Walnut, Almonds etc.,

Endometritis in cow is actually the inflammation of endometrium that is inner lining of the uterus. It occurs after bacterial contamination of uterus at calving, during A.I. following dystocia, retention of placenta, abortion etc. There is expulsion of white or whitish-yellow muco-purulent discharge from vagina. The animal does not shows systemic signs like increase in temperature, increase in respiration rate, anorexia, toxemia etc as in metritis. However, the animal fails to conceive even after repeated inseminations.

Abstract

Variously defined endophytes are highly diverse in plants in natural ecosystems, and most of them are symbiotic with of them are Asymptomatic presence of endophytic fungi in internal tissues on healthy host plants are able to play vital roles in physiology and biochemical processes. As a result of this interaction endophyte produces chemical substances having various applications. This chapter provides a brief review of certain grass and non-grass endophytes capable to extend beneficial impacts on host plants to sustain the unfavourable conditions of abiotic stresses. However, biotic stresses are also a matter of great concern, where endophytes can play important roles in combating the unfavourable situation. Endophytic fungi used in bio-control and other agriculture related sectors are also  highlighted in this review. Endophytic fungi producing volatile organic compounds reported from all over the world and their various applications find place in this article which has opened new frontiers of bioprospecting of endophytic fungi.

Introduction
Antimicrobial resistance (AMR) is a critical public health problem globally, which can shake the foundation of modern healthcare. Infections caused by drugresistant organisms could lead to increased mortality and prolonged duration of hospitalization, causing a huge financial burden to the affected persons, healthcare systems and hinder the goals of sustainable development. With rising AMR, antibiotics are increasingly becoming ineffective for treating diseases.The post antibiotic era is not a dreadful imagination but a potential reality unless effective global actions are initiated now (1). AMR is not the only problem of human health, it widely affects the animal husbandry as well as environment. In India in 2019, there were 297,000 deaths attributable to AMR and 1,042,500 deaths associated with AMR. India has the 145th highest age-standardized mortality rate per 100,000 population associated with AMR across 204 countries.The number of AMR deaths in India is higher than deaths from neoplasms, respiratory infections and tuberculosis, enteric infections, diabetes and kidney diseases and maternal and neonatal disorders.Out of 10 million projected human deaths in 2050, one-fifth may be from India (2).Annually, more than 50 000 new-born are estimated to die from sepsis due to pathogens resistant to first-line antibiotics. The median cost of treatment of a resistant bacterial infection in India is estimated to be more than a year’s wages of a rural worker. There are five pathogens to be aware of in India (number of deaths associated with AMR in parenthesis): Escherichia coli (152,700), Klebsiella pneumoniae (123,200), Staphylococcus aureus (111,400), Acinetobacter baumannii (103,500), and Mycobacterium tuberculosis (98,600).If there is no timely containment, AMR is likely to cause nearly 10 million deaths by 2050 and resulting in significant economic losses. It would also impact nutrition security, livelihood and hinder the attainment of the Sustainable Development Goals. In 1928, penicillin was developed and socalled magic drug was subsequently commercialised and used globally. When antibiotic resistance ?rst emerged, novel antibiotics to treat these bacteria were developed. However, it is dif?cult to develop effective new antibiotics every time as it is time consuming and costly and if developed a new resistance mechanism emerges in bacteria. There is a demand for new strategies to treat bacterial infections, such as endophytes therapy, phage therapy, antimicrobial peptides, CRISPER cas and so on.

Microbes that live inside plant tissues without causing disease are termed as endophytes. Endophytes have been found in all parts of plant viz., seeds, roots, stems, leaves, fruits etc. Within these organs, there is evidence of endophytes living in apoplastic intercellular space within parenchyma tissues and xylem vessel apoplast. Endophytic bacteria have been isolated from both monocotyledonous and dicotyledonous plants, ranging from woody tree species to herbaceous crop plants. Further, a single plant may be a host for several different bacterial species. They are consistently present in the root, stem, leaf, fruit and tuber tissues of a wide range of agricultural, horticultural and forest species. All plants in nature harbor a diverse community of endophytic bacteria which can positively affect host plant growth.

The potential of endophytic bacteria to fix nitrogen, promote plant growth and suppress plant diseases has renewed interest in such associations. It is advantageous to have the endophytic plant growth promoting organisms safely inside the plant, which could supply substantial amounts of nitrogen and other nutrients, growth hormones and other beneficial effects to the crop plants without the interference of the rhizosphere soil environment. Furthermore, plant growth promotion is often greater when it is induced by endophytes rather than by rhizosphere bacteria.