eChapters

Fruits represent a vital component of global agriculture, serving as not only a significant source of essential nutrients but also a lucrative sector of the economy. However, from the moment of their inception on the tree to their arrival on consumers’ tables, fruits undergo a complex journey influenced by a myriad of factors. Among these, pre-harvest practices wield a profound impact on fruit quality, enzymatic activities, texture, ripening, and ultimately, post-harvest transportation losses. Each pre-harvest practice, from mineral nutrition to harvesting methods, plays a distinct role in shaping the biochemical composition and physical attributes of fruits, ultimately affecting their marketability and shelf life. Mineral nutrition stands as one of the foundational pillars of fruit production, with essential minerals serving as building blocks for various biochemical processes. Irrigation practices represent another critical aspect of pre-harvest management, as water availability profoundly impacts fruit development and composition. Different irrigation regimes can influence enzymatic activities, fruit texture, and the timing of ripening, necessitating strategic water management to achieve desired fruit quality while minimizing post-harvest losses. Canopy regulation, achieved through training and pruning techniques, offers growers a means to manipulate light penetration and airflow within the orchard. Moreover, the application of plant growth regulators (PGRs) emerges as a tool for fine-tuning fruit development and ripening processes. By modulating hormonal signals, PGRs can alter enzymatic activities, influence fruit texture, and mitigate transportation losses. However, judicious application is paramount to avoid adverse effects on fruit quality and safety. Harvesting decisions, including the determination of optimal maturity and the timing and method of harvest, profoundly impact fruit quality and post-harvest losses.

Horticulture crops contribute significantly for the total agricultural production and productivity. World production of fruits accounted for the total volume of 933 million tonnes (FAO, 2023). India being second largest producer for majority of fruit commodities had a production total reaching 108.34 million tonnes in 2022-2023 from an area of 7.15 million hectares. It accounts for 33 per cent to the agriculture GVA (Gross Value Added) and plays an important role in the Indian economy. India is second largest producer of majority of fruits and vegetables. Diverse agro-climatic zones in the country make it possible to grow almost all varieties of fruits in India. Produced fruits are used for domestic consumption, processing and export purposes. During 2022 23, fresh fruits exports was valued at 6219.46 crores (APEDA, 2023). The fruits grown in India includes domestic fruits and nuts along with the exotic fruits contributing for the food and nutritional security. The growth of these economically important fruits provides scope for maintaining rich germplasm, enhance bio-diversity and maintain ecological balance.

Introdction

Fruits are an important supplement to the human diet, as they provide minerals, vitamins and fiber required for maintaining good health. Fruits are also rich in phytochemicals (7, xanthophylls, polyphenols, flavonoids, phenolic acids, organic acids etc.) which possess good antioxidant properties. India’s diverse climatic conditions ensure availability of almost all the varieties of fresh fruits and vegetables. According to FAO (2021), the country ranks first in the production of bananas (26.45%), mangoes (including mangosteens and guavas) (43.80%) and papayas (39.30%). The scenario of horticulture crops in India has become very encouraging. The percentage share of horticulture output in agriculture has become 33 per cent (Anonymous 2021). India has witnessed increase in horticulture production over the last few years. Significant progress has been made in area expansion resulting in higher production. Over the last decade, the area under horticulture grew by 2.1 per cent per annum and annual production increased by 3.9 per cent. During 2020-21, the production of horticulture crops was 334.60 million tonnes from an area of 27.74 million hectares. The production of fruits has increased from 76.42 million tonnes in 2011-12 to 108.34 million tonnes in 2022-23 (Agricultural Statistics at a Glance 2022). The area under cultivation of fruits stood at 7.05 million hectares. The total production of fruits in the year 2020-21 was highest in case of Andhra Pradesh (17.70 million tonnes) followed by Maharashtra (11.73 million tonnes) and Uttar Pradesh (11.23 million tonnes) (Anonymous 2021). India now is the second largest producer of vegetables and fruits in the world. The country ranks at first position in the production of banana, mango, lime and lemon, papaya and okra. The area and production of fruits in India is presented in Table 1. The fruits namely banana, mango, citrus, papaya, guava, grapes, apple, pineapple and sapota account for more than 85 per cent of the total production of fruits. The other fruits which are produced in India are almond, walnut, jackfruit, bael, ber, custard apple, kiwi, passion fruit, peach, pear, plum, strawberry etc.

For effective and economic control of pests, besides selection of appropriate plant protection chemicals, application of the chemicals at the most vulnerable growth stage of the pests and use of chemicals at the correct dosage, selection of proper plant protection appliances to carry out the operation is also of vital importance, so as to ensure uniform application of the chemicals.

Plant protection chemicals are mostly used as sprays and dusts using sprayers and dusters respectively. However, in most of the cases spraying is preferred to dusting. Different types of sprayers and dusters are being used for these operations and in both, there are manually operated as well as power operated equipments and in sprayers there are both hydraulic and pneumatic types of sprayers.

The nature of the pesticide formulations to be used and the purpose for which they are used also determine the type of equipment to be used. Dusters are used for dusting insecticidal dust formulations. Sprayers are used for spraying insecticidal liquid formulations. Granular applicators are used to apply granular formulations. Fumigators are used to apply fumigants to fumigate godowns, warehouses, rat holes etc. Soil injectors are used to inject pesticides at a particular depth of soil under pressure. Flame throwers are used to throw f lames at specified targets.

The chemicals, which can destroy pests or prevent their occurrence by their chemical action are known as ‘Pesticides’. Pesticides include ‘insecticides’, acaricides’, ‘nematicides’, rodenticides’, molluscicides’ etc., which are used to destroy insect pests, mites, nematodes, rodents, slugs and snails respectively. Pesticides have been used even before the time when man never knew how to read and write. Even before 200 BC, several substances were known to control pests. Sulfur, arsenic poisons, fluorine poisons, as well as some plant extracts and oils were used to control pests. However, these substances could destroy only a few specific pests only to some extent.

Advances in the invention of pesticides

The invention of many of the present day pesticides started only after 1867. ‘Paris green’, a synthetic chemical was the first pesticide used to control the ‘Colorodo beetles’ of potato. Up to 1939, only a few inorganic chemical compounds and plant poisons were used as pesticides. Only after the Second World War much advances were made in chemical research. After the invention of DDT in 1939, a revolution had started in the field of pest control. Following the introduction of DDT, several other pesticides were identified and introduced for pest control. In 1941, BHC was invented by the British and French scientists. During the same period, organophosphorus pesticides were invented by the German scientists and parathion, malathion, demeton etc. were introduced.

‘Insect pest control’ includes all measures adopted to make the life of insects hard and ultimately to destroy them or to prevent their multiplication and spread. Such measures can be taken up before the appearance of the pests or after occurrence of the pests. To achieve this purpose , it is quite necessary to know the factors, which favor the occurrence of the pests and acquire enough knowledge about the nature and life cycle of the pests, the vulnerable growth stage at which they can be effectively destroyed and appropriate measures of control to destroy them Control measures may be either preventive or direct.

Need for pest control

Control measures for the control of pests have to be taken up as soon as the infestation reaches the economic threshold level. Failure to control the pests at this stage will result in further increase in the pest population and consequent loss in yield and economic loss.

The need for pest control is of two kinds :

i) For yield maximization. The only objective of pest control in this method is to maximize the yield. The cost incurred for pest control is most often more than the income accrued as a result of pest control. The method is adopted only with the object of increasing the yield as much as possible so that the country and the people may be benefited. In this method, pest control operations are taken up before the actual occurrence of the pest or before the pest infestation reaches the economic threshold level. Such treatments taken up to control the pests before their occurrence are known as ‘prophylactic treatments’

Pests

The English name ‘Pest’ is derived from the Latin word ‘Pestis’, which means causing destruction. Pests are defined as ‘those organisms, which compete with man in his food supply, damage his possessions and attack himself’. They are of vital concern to mankind in their everyday life, as they cause considerable damage directly as well as indirectly to crops, domestic animals, birds and to man himself. They are also responsible for causing or transmitting many serious diseases. Pests include thousands of invertebrates such as, insects, nematodes, mites, ticks, snails and slugs, crabs etc. and vertebrates such as, rats, squirrels, jackals, pigs and boars, porcupines, rabbits, deers, bats, some species of birds etc., which are destructive to plants and livestock. Several microorganisms such as, fungi, bacteria, viruses, mycoplasma, phytoplasma etc. are also pests in nature. Weeds and phanerogamic parasites are also pests in the true sense.

By 2050, the global population is projected to reach approximately 9.8 billion, requiring a 70% increase in food production to meet the growing dietary demands. The livestock sector will play a crucial role in addressing this rising need through sustainable animal production, contributing to food security, poverty alleviation, public health, and food safety. To tackle the challenges posed by population growth and to achieve the United Nations Sustainable Development Goals (SDGs), technological advancements and innovations will be essential in transforming the food and agriculture sectors.

In light of these challenges, Veterinary Services are more critical than ever. They are essential for enhancing livestock health and productivity, ensuring high-quality food that meets safety standards, and mitigating risks associated with animal diseases and public health. Additionally, Veterinary Services must contribute to global efforts in addressing issues such as food security, antimicrobial resistance, climate change, and the depletion of natural resources.

Introduction

As India is the leading global economy with livestock contributing 4.66% in total GVA to Indian Economy (PIB, 2024) and ranks 1st in Milk Production, 2nd in Egg production, 5th in meat production (BAHS, 2024). Being the largest exporter of milk and meat in the world , this has led to the intensification of animal production due to the increasing demand of major livestock products (MLPs), which has led to an increasing overall use of antimicrobials. Antimicrobials are invariably used to preserve animal and public health, but also as growth promoters at a sub-therapeutic level. The overuse and misuse of antibiotics can contribute to antimicrobial resistance. The growing resistance to antimicrobial drugs could reverse the therapeutic benefits; animals’ resistance to antimicrobial drugs, reduces productivity and leads to economic losses. Unwanted antimicrobials residues may be present in products of animal origins, in animal waste contaminating soil and water and the environment. Seventy-five to ninety percent of antimicrobials used in livestock are excreted, mostly unmetabolized. AMR poses a serious threat to the safety and quality of animal origin food, food security and livelihoods. Unhealthy and unproductive animals are no longer able to generate food products of acceptable safety and quality for human consumption and can no longer contribute to income generation. Insufficient standards for residues in animal food products, reduces the livestock sectors potential of access to trade and increases public health risks (https://www.fao.org/antimicrobial-resistance/key-sectors/animal-production/ en/).

Introduction

Wound is a disruption to the epithelial integrity of the skin, extended in-depth to subcutaneous tissue and other body parts such as ligaments, muscles, blood vessels, nerves, and bone (Robson et al. 2001). An appropriate wound healing is essential for the restoration of disrupted anatomical continuity (Begum, 2000). We have observed increasing interest in research based on traditional medicines of the world in the recent era (Medina-Franco et al. 2013). Traditional and complementary medicine regains popularity not only in developing countries but also in developed countries. Common and known practices across the globe of traditional medicines include Herbal, Ayurveda, Siddha, Unani, Iranian, Islamic, Vietnamese, Chinese, Acupuncture, African and other pseudo-medical knowledge (Dorai 2012). According to World Health Organization (WHO), traditional medicine ‘the health practices, approaches, knowledge and beliefs incorporating plant, animal and mineral-based medicines, spiritual therapies, manual techniques and exercises, applied singularly or in combination to treat, diagnose and prevent illnesses or maintain well-being’. Saxena et al. (2013) reported that phytochemicals present in plants are liable for preventing disease and promoting health. Antibiotics used in the treatment of wound infections are now proved to have adverse effects in the human body and in pathogens where resistance is emerging. Attention has, therefore, turned towards extracting biologically active compounds from plant species having wound healing property (Pattanayak and Sunita, 2008).

Introduction

Canine epilepsy, a prevalent neurological disorder, significantly impacts the quality of life for both dogs and their owners. Traditional anticonvulsant therapies often yield inconsistent outcomes, necessitating the exploration of alternative treatments such as homeopathy [1][2]. Homeopathy’s individualized approach aligns with the principles of unicism, focusing on holistic care tailored to each patient’s unique symptom profile [3]. However, the subjective nature of remedy selection and response assessment poses challenges for practitioners.

The integration of Artificial Intelligence (AI) and Machine Learning (ML) offers a promising avenue to address these challenges [4]. Predictive models can analyze complex datasets to uncover patterns that guide remedy selection and treatment strategies. This study evaluates the comparative performance of Logistic Regression, Random Forest, and XGBoost in predicting treatment outcomes for canine epilepsy managed with homeopathic remedies.

Introduction

Avian medicine is a rapidly growing field, with an increasing number of exotic bird species being kept as pets. However, the unique anatomy, physiology, and behaviour of these birds present several challenges as well as new opportunities for veterinarians and researchers.Now a day’s birds are gaining popularity over dogs and cats because of various reasons listed below:

a. They are more suited in present life style as can be suited well in small spaces.

b. They require low maintenance with relative low cost of maintenance and live longer life.

c. They form very strong bonds with their owners.

Birds can be classified into different families, such as Psittaciformes, Passeriformes, Columbiformes, Piciformes, Anseriformes, Galliformes etc. containing numerous species (>10,000). The first documentation of parrot as a pet was found in Rig Veda, written more than 3000 years ago. Evidence of bird keeping is observed in ancient civilizations of Greece, Rome, China and Egypt. In Greek mythology, Raven (a crow) was mentioned as a symbol of good luck and was associated with God Apollo (God of prophecy). Crows are also considered as ancestors in Hindu mythology and food (pinda) is offered to crows during ritual of paying homage to dead persons. In most of the countries psittacine and passerine birds are preferred as pet birds.

Introduction

Mithun (Bos frontalis), or ‘Gayal’ or ‘Eso’ or ‘Sial’ or ‘Sandong’ or ‘Wei’, is a rare bovine species, exclusively found in the northeastern hill region (NEHR) of India at an altitude of 300-3000 m. It plays an important role in the socio-economic and cultural life of indigenous tribes of Arunachal Pradesh, Nagaland, Mizoram and Manipur and is aptly referred to as the ‘Pride of Northeast India’ (Mukherjee et al. 2019). Besides India, mithun population is distributed to China, Bangladesh, Thailand, Bhutan, Myanmar, and Malaysia. The Indian mithun is a medium- to large-sized majestic ruminant with a characteristic jet-black body, an ash-colored forehead, and ‘white stockings’ on all the limbs. This unique animal has a special preference for salt feeding, is a skilled browser even in steep, hilly terrain, and does not need pasture land like cattle. Mithun is primarily reared under a free range system as an important source of lean meat, rich in amino acids, proteins, PUFA, etc. On September 1, 2023, the Food Safety and Standards Authority of India (FSSAI) officially certified the mithun as a food animal (Joshi et al., 2021; Lalchamliani et al., 2024; Ramesh et al., 2024). Compared to milk from other species, mithun milk has much larger quantities of fat, lactose, solids-not fat (SNF), calcium, important vitamins A, D, and E, essential amino acids, and polyunsaturated fatty acids (Devi et al., 2023).

Introduction

A complete neurological examination is warranted whenever an equine patient displays signs consistent with neurological disorder or to establish that the horse is neurologically normal (e.g., pre-purchase examination). Neurological examination of equine patient is challenging due to their large size, which prevents veterinarian from using many of the tests used for small animals. The key to a successful neurologic examination is to do the examination in a consistent and organized fashion. It is important to develop a routine, then do it the same way each time. This approach ensures that some parts of the examination are not forgotten and it also increases the consistency of the exam as you examine more number of equine patients. A standardized examination form is a valuable aid in this and can be concise. The goals of the neurologic examination are to determine whether disease of the nervous system exists, to localize the lesion to a particular area of the nervous system, and to describe and record the responses as a baseline for future evaluations. In this paper, a complete neurological examination is described with special emphasis on field conditions.

Asiatic Elephant (Elephas maximus) is the national heritage animal of India. This particular species now exists in 13 Asian countries including India. As per 2017 census, India is home to an estimated figure of 29,964 elephants that is >60% wild population of the globe. Once distributed across the country, now they are squeezed to 14 states grouped in four regions ie., southern (14,612), north-eastern (10,139), east-central (3,128) and northern regions (2,085). There are 2675 captive elephants across different states under both private and government custody. This largest terrestrial mammal is protected under Seclude I species of Indian Wild Life Protection Act, 1972.

Both central and state Government are implementing short- and long-term programmes for health and well-being of captive as well as free-range elephants. The Central Government has established an ‘Elephant Cell’ at the Wildlife Institute of India (WII), Dehradun to provide technical inputs to the ministry for strengthening the efforts towards conservation of elephants. Add-on, the ‘Project Elephant’ was launched in 1991-92 in the Ministry of Environment, Forests and Climate Change to restore the elephant habitats and reduce their sufferings. Elephant habitats are notified as Elephant Reserves that are basic management units for elephant conservation and managements. A total of 33 Elephant Reserves has been notified in the country. A book titled, ‘Caring for elephants: Managing health and welfare in captivity’ is edited for field officers, veterinary professionals and elephant handlers.

Learning objectives

1. Recognise inflammatory cell types

2. Recognise common skin pathogens

3. Diagnostic test are best for each case

4. Gain experience in interpretation

5. Recognise important artefacts

″The most crucial step towards healing is having the right diagnosis″. While approaching a case, a clinician should follow appropriate steps in a systematic way for accurate diagnosis of dermatological disorders. A careful history is a first step to choose appropriate diagnostic tests.

Introduction

Canine atopic dermatitis (CAD) is a chronic inflammatory skin disease marked by itching (pruritus), redness (erythema), and recurrent infections. While traditionally considered an immune-mediated condition, recent studies highlight the significant role of skin barrier dysfunction in its development. A key aspect of CAD is the compromised skin barrier, which increases permeability to allergens, irritants, and microorganisms, thereby worsening the disease. The skin barrier is a complex, dynamic structure essential for protecting dogs from environmental challenges. The stratum corneum—the outermost layer of the epidermis—serves as a crucial defense against environmental insults, allergens, and pathogens. In dogs with atopic dermatitis, this barrier often becomes impaired, leading to increased transepidermal water loss (TEWL), greater allergen penetration, and secondary infections. This dysfunction both results from and contributes to the condition, creating a self-perpetuating cycle of barrier disruption, inflammation, and immune dysregulation.

As the heart diseases in companion animals is becoming common as in humans, the research in canine cardiac diseases is one of the most extensive studies in the present scenario. As per the available literature, the overall occurrence of various cardiac abnormalities ranges from 0.37 percent to 1.67 percent in various parts of the country. Whereas, in western parts of the globe, nearly 8 million dogs suffer from heart disease accounting 10% of all dogs in the United States. Heart diseases are common among older dogs; up to 75% of senior dogs have some type of heart condition, and unfortunately, most go undiagnosed due to varied reasons. The recognition of canine cardiac diseases has been delayed, and ignored on account of lack of awareness and knowledge by the owner and inadequate diagnostic facility in our country. Physical examination, radiography, electrocardiography and echocardiography are most useful diagnostic procedures employed in diagnosing the cardiac diseases in dogs. However, majority of the acquired cardiac diseases are being managed medically with one or a combination of drugs. Improved diet management and health care of companion animals have led to increased life expectancy, as a result, cardiac diseases have become pivotal causes of death for both dogs and cats. For such reason, a major objective has become to increase the quality of life by reducing the expansion of cardiac diseases via early detection of diseases and provision of effective treatment.

Renal failure is one of the most commonly presented conditions in veterinary clinics world over. Although the potential for recovery is favorable, most animals die due to multisystemic effects induced by azotemia. Hence, extracorporeal removal of endogenous and exogenous toxins is very essential for expanding the window of recovery. Hemodialysis has been used in treatment of veterinary patients for the last 50 years and is still one of the most expensive and technically demanding treatment modalities in veterinary medicine. It is an advanced extracorporeal renal replacement therapy which has recently transitioned from a clinical curiosity to a more advanced standard for management of acute kidney injury (AKI) and chronic kidney disease (CKD) in companion animals particularly dogs and cats.

In addition to eliminating selective toxins that cause AKI, regardless of renal function, hemodialysis is also effective in the removal of pharmacokinetically active soluble uremic substances in CKD to enhance life expectancy and quality of life (Singh, 2021). Other common indications of hemodialysis in veterinary medicine include fluid overload, dysregulated body fluid composition, drug overdose or intoxications (Foster, 2020; Singh et al?, 2024). Medical management alone is often insufficient to control the clinical signs and metabolic abnormalities associated with uremia when AKI is severe or when there is involvement of acute on chronic kidney disease. Consequently, animals are at risk of death within a short therapeutic window, despite the potential reversibility of AKI and the improvement of life expectancy in CKD.

Introduction

One of the remarkable advancements in veterinary medicine recently is the application of interventional cardiology techniques to treat various congenital heart diseases. In dogs and cats, congenital heart diseases can be treated much more easily and with fewer complications using minimally invasive interventional approaches, rather than through traditional open-heart surgery. Among congenital heart diseases, treatment options are available for conditions such as PDA (Patent Ductus Arteriosus), AS (Aortic Stenosis), PS (Pulmonic Stenosis), VSD (Ventricular Septal Defect), ASD (Atrial Septal Defect), extrahepatic shunt, and stem cell applications. These diseases often cannot be significantly improved by medical treatment alone, making the use of the aforementioned interventional techniques essential for effective management.

Precision medicine and personalised treatment of systemic or tumour diseases gain their acceptance and application in veterinary care, too. The application of personalised medical protocols and companion diagnostics is easier and ethically well reasoned within the veterinary medical field – and it can offer many advantageous lessons to human clinical transformation, too [1]. In vitro companion diagnostics for testing the applicability and sensitivity levels of certain kinase inhibitor and immunotherapeutic drugs offer a greatly increased efficiency for veterinary cancer patients, too. As the understanding of cancer biology has advanced, the field of veterinary oncology has grown significantly, paralleling developments in human oncology. Precision medicine is an innovative approach to disease treatment and prevention that considers individual variability in genes, environment, and lifestyle. In the context of veterinary medicine, precision medicine aims to provide tailored therapies that are specifically designed for the unique genetic and molecular profile of each animal’s cancer. This approach moves away from the traditional “one-size-fits-all” model, instead focusing on targeted treatments that maximize efficacy while minimizing side effects. Companion diagnostics, such as molecular tests, help determine whether a dog or cat is likely to respond to a particular drug. For dogs and cats, precision medicine holds great promise in improving outcomes for cancers, which are among the leading causes of death in companion animals.

Tissue Doppler Imaging

Doppler echocardiography relies on detection of the shift in frequency of ultrasound signals reflected from moving objects. With this principle, conventional Doppler techniques assess the velocity of blood flow by measuring high-frequency, low amplitude signals from small, fast-moving blood cells. In TDI, the same Doppler principles are used to quantify the higher-amplitude, lower-velocity signals of myocardial tissue motion.

There are important limitations to TD interrogation. As with all Doppler techniques, TDI measures only the vector of motion that is parallel to the direction of the ultrasound beam. In addition, TDI measures absolute tissue velocity and is unable to discriminate passive motion (related to translation or tethering) from active motion (fiber shortening or lengthening). The emerging technology of Doppler strain imaging provides a means to differentiate true contractility from passive myocardial motion by looking at relative changes in tissue velocity.

Cardiomyopathies in acts can be classified broadly as Hypertrophic cardiomyopathy and non-hypertrophic cardiomyopathies. Usually, no alarming clinical signs are detected during routine examination in the preclinical stage except cardiac murmurs in some cats with HCM. This is because, that the cats are sedentary and excellent in hiding the signs of illness from the pet parents. Hence the onset is often acute with the sudden appearance of the clinical signs linked to congestive heart failure like severe dyspnoea, cardiogenic shock, aortic thromboembolism, arrhythmias and even syncope and death

Cats with CHF will be presented with severe dyspnoea, due to fulminant pulmonary oedema and or pleural effusion. The pleural effusion associated with CHF is usually a modified transudate, some cases it may be chylous .In echocardiography ,the size of the left atrium should be determined .If the LA size is normal ,then the dyspnoea may not be of cardiac origin .The presence of B-lines in the lung area in association with LA enlargement confirms cardiogenic pulmonary oedema. Stress, anaesthesia, I/V fluids and steroids leads to decompensation and fulminant pulmonary oedema. Thoracocentesis is will be helpful if there is dyspnoea due to significant pleural effusion. At least 300ml of effusion can be usually removed. The dyspnoeic cat is very fragile and should be handled carefully. Butorphanol may be given for anxiolytic effect. Oxygen administration is beneficial. Furosemide when given intravenously has an initial venodilator effect and should be repeated as required monitoring the sleeping respiratory rate (SRR). Addition of nitro-glycerine (vasodilator) reduces preload, decreases left atrial pressure and help in reducing pulmonary oedema. If the clinical signs are suggestive of cardiogenic shock or myocardial failure, Pimobendan I/V or Dobutamine CRI should be considered.

Cytauxzoonosis is an emerging tick-borne disease of domestic cats and wild felids caused by the protozoa of the genus Cytauxzoon. The common clinical findings in affected cats are similar to other hemoparasitic infections namely anorexia, depression, anemia, vomiting, icterus, and high fever. The first reporting of feline cytauxzoonosis with four fatal cases was done by Wagner in Missouri, USA in the year 1976.

Bobcats (Lynx rufus) are recognized as the natural wild reservoir of Cytauxzoon felis with prevalence reaching up to 100% in some enzootic areas (Zieman et al., 2017). This infection is highly fatal in domestic cats with 97% mortality without treatment (Meinkoth and Kocan, 2005). However, subclinical infection in some cats has also been evidenced i.e., they were infected with C? felis but did not display the acute clinical signs of the disease before diagnosis (Brown et al., 2010 and Rizzi et al., 2015).

Several other wild felids apart from bobcats and domestic cats have been found to be affected by fatal or nonfatal Cytauxzoon sp. infection. These include lions, jaguar, cougars, pumas, ocelots, Iberian lynx, meerkats, European wild cats and Asiatic wild cat, panthers, and tigers (Jakob and Wesemeier, 1996; Rotstein et al., 1999; Yabsley et al., 2006; Andre et al., 2009; Filoni et al., 2012 and Furtado et al., 2017).

The Central Nervous System not only consists of the Brain but also involves the Spinal cord.

The spinal cord is responsible for conveying information from the Brain to the rest of the body via the peripheral nervous system. The spinal cord can be divided into 4 functional segments.

1. C1-C5 (Upper Cervical Segments)

2. C6-T2 (Brachial Plexus)

3. T3-L3 (Thoraco - Lumbar)

4. L4-S3 (Lumbo-Sacral Plexus )

It is important to note that the motor and sensory function of the pelvic limbs are not only controlled by the Lumbo-Sacral plexus but also involve the Thoraco Lumbar segments (T3-L3) of the spinal cord. It is important to understand not only the neuroanatomy, but also the functional anatomy before approaching a neurological patient.

AMR is undoubtedly the most serious challenge ever faced by the world health community because of its multifaceted complex nature and its overwhelming impact over the human and veterinary communities. Livestock sector is no exception to have the serious and devastating impact from the emergence and spread of AMR. Because of a steady shift towards intensive farming and increased stocking density there has been increase occurrence of infectious diseases. Growing world population, rapid urbanization, and deforestation, shrinkage of grazing land all aided to this process. This leads to increased usage of antimicrobials in food animals – cause of concern for the scientific community as AMU is known the single most important driver of AMR.

Punjab, known as the “breadbasket of India,” relies heavily on livestock, particularly cattle and buffalo, for its agricultural prosperity. These animals play a crucial role in the region’s dairy industry, contributing significantly to milk production and rural livelihoods. However, like all livestock, cattle and buffalo in Punjab are susceptible to a range of diseases that can impact their health, productivity, and overall well-being. Timely and accurate diagnosis is essential for effective treatment and prevention. This article explores some of the most common diseases affecting cattle and buffalo in Punjab, along with the diagnostic procedures used to detect and manage these health issues, ensuring the sustainability and growth of the dairy sector.

Hydatidosis

Hydatidosis is a zoonotic disease caused by metacestode stages of parasite Echinococcus granulosus and is recognized as a major public health problem worldwide. This tapeworm is found in small intestine of the canid (definitive host) where it produce proglottids containing eggs. Upon shedding through faeces the later are ingested by the cattle, buffaloes and other intermediate hosts including man. These hatch in their intestine and the oncosphere invade circulatory system and lodge in various organs (liver, lung, brain etc.) where they develop into large thick walled unilocular cavity called hydatid cyst, which expands and can reach very large size and buds hundreds and thousands of protoscoleces endogenously. In a survey on hydatid cysts, a prevalence rate of around 5% has been recorded in more than 4000 meat samples of different animals in Punjab.

Introduction

Climate change, a global phenomenon of present time, has emerged as the greatest challenge of the world in the twenty-first century. Rising earth’s surface temperature is one of the most threatening factors coming into view. The substantial changes in the earth’s climate have an impact on ecosystems, economics and societies in a variety of ways (Sharma et al., 2024). It is one of the important environmental, agricultural, human and animal health issue. Climate change is an association of multidimensional effects involving physical characteristics, causes and consequences (Visschers, 2018). The climate change has resulted in to increasing global average temperature of air and ocean, melting of snow, rising of ocean level, change in the rainfall pattern and extreme whether events such as drought, flood, heat waves, storms etc.

Being polytocous animal, sow give birth several (8-14) piglets in each farrowing, mother pig find several deficiencies and disorders during gestation, farrowing and postnatal conditions. Prior to birth intrauterine competition amongst the feotus piglets for nutrition and gas exchange is a big stress for abortion. Several infectious and non-infectious causes may hamper proper growth and pathological conditions resulting mortality (15-20%) in piglets than weaner and adults (Sarma, et al, 2012). Several risk factors are also responsible for piglet mortality.

Prenatal factors: Insults during pregnancy can impact a piglet’s ability to survive after birth and regulate their body temperature. Some maternal aspects that affect survability and mortality amongst piglets are prolong farrowing duration more than 4 hours, number of parity of sow, usually first and second parity show high mortality than subsequent parities and also older sow lose more piglets.

Veterinary Nuclear Medicine (VNM)

Veterinary Nuclear Medicine (VNM) is a specialized field that uses radioisotopes to detect, diagnose, and treat diseases. Gamma scintigraphy involves injecting radioactive tracer pharmaceuticals into the animal’s body and imaging them as they move through the body using a gamma radiation-sensitive camera. This technique provides a 2D or 3D image of the whole body or a specific organ, allowing for the estimation of the quantitative distribution within the region of interest (ROI). Advancements in gamma scintigraphy have allowed for the acquisition of information about both static and dynamic high-resolution images, such as heart wall motion, blood flow, and myocardial perfusion. Unlike other diagnostic modalities viz X-rays, ultrasonography, and CT; gamma scintigraphy offers functional information of specific organs. The most commonly used gamma radiation-emitting isotope is 99m-Technetium (99mTc), which emits a gamma energy of 98% 140-keV photon with only 10% internal conversion. Other radionuclides used in veterinary nuclear medicine facilities include iodine (123I and 131I), Gallium (67Ga), and Thallium (201Ti).

Rabies is an ancient, dreadful disease known to mankind from the vedic ages. It is a zoonotic disease caused by Rabies virus, genus Lyssavirus family Rhabdoviridae, affecting all mammals including man. The WHO categorizes rabies as a neglected zoonotic disease that causes around 59,000 human deaths globally annually after onset of symptoms. It is a vaccine preventable disease reported from over 150 countries and territories barring the island nations like Australia, Brunei, Japan, Maldives, New Zealand, Papua New Guinea, Singapore, Timor Leste and the Pacific Island Countries. The Indian islands of Andaman Nicobar and Lakshadweep are rabies free so far.

On the other hand, Africa and Asia has the highest burden of human rabies including South-East Asia: Bangladesh, Bhutan, DPRK, India, Indonesia, Myanmar, Nepal, Sri Lanka, and Thailand. The Asia Pacific region having 60% of the world’s population includes the world’s most populous countries – India and China. Asia alone shares almost half of the global rabies deaths annually.

Opportunities

India is home to largest milch animal population, totalling around 100 million cattle and buffalo (out of total population of 300 million) spread over 6.5 million census villages. India is the largest milk producer with CAGR of 4.5%, likely to go up to 5%, which is likely to create around 20 million jobs every year. The most significant factor is that dairy industry is likely to exceed IT industry in employment generation. In year 2018, India produced 146 million tonnes of milk contributing 26% of the agriculture GDP.

But the foundation of dairy industry is economically vulnerable as per animal productivity and fertility are very low leading to meagre profits and frequent demands to enhance procurement price. National schemes like Operation Flood, National Dairy Plan-I and National Dairy Plan II, largely focussed on milk collection, processing, distribution and organising farmers but the animal component has been neglected. Enhancing per animal productivity by empowering farmers to scientific management and breeding to achieve genetic improvement needs urgent attention. Although numerous technologies to improve health and genetics are available but the single most important gap is failure to deliver these to farmers. Unlike western world, India has not been able to develop modern veterinary service delivery models. In order to cater to breeding and health services of cattle and buffalo (300 million in numbers) and also pet animals in rural areas and small towns, huge manpower and infrastructure will be required.

Veterinary oncology is an upcoming field in recent years due to the integration of the importance of spontaneous canine cancers in understanding and developing novel strategies for human cancer management. We are stepping towards a very exciting era in veterinary oncology, where comparative oncology has played a significant role for many decades in understanding the molecular basis of cancer in companion animals. The comparative animal models have generated remarkable interest in both academia and industry. Studies have demonstrated the utility of comparative oncology in understanding drug resistance and tumor biology, contributing to the translational research[1]. This has yielded breakthrough discoveries, from advanced diagnostics to novel therapies, providing opportunities to improve the longevity and quality of life of the pets. These inputs have led to advancements such as the first conditionally approved chemotherapeutic agent for lymphoma, novel BRAF testing for canine urothelial carcinoma, tyrosine kinase inhibitors for mast cell tumors, updates in stereotactic/FLASH radiation, and novel immunotherapeutics. As the understanding of cancer biology has advanced, the field of veterinary oncology has grown significantly, paralleling developments in human oncology. Veterinary oncologists treat a variety of cancers in domestic animals, particularly dogs and cats, but also in exotic animals, horses, and even zoo animals. While the types of cancers in animals share similarities with human cancers, treatment strategies can differ significantly due to species-specific differences in anatomy, physiology, and response to therapies [2, 3].

Introduction

In the last decade, digitalization has transformed every aspect of life and society, changing almost every area of our day-to day lives. Not just that; the rate of change that is happening is astonishing and only going to accelerate further. From the way, we work and communicate to how we organize our lives, digital tools and technologies are everywhere including the veterinary sector. Veterinarians are recognizing the need to depart “the analog island” and increasingly willing to embrace digital solutions. Undoubtedly, digitalization is crucial when it comes to boosting efficiency and quality in veterinary medicine and delivery of animal healthcare to masses across various geographies and resource poor setups. Uniquely these digital tools helps vets also to focus on the needs of patients and animal owners.

14.1 NEED FOR ANIMAL DISEASE INFORMATION SYSTEMS

Once the animal disease data are gathered, a few things need to be done with the data so collected. First, they must be managed and quality checked; Secondly, they must be analyzed to be understandable; and thirdly, they must be acted upon. For data to be analyzable and useful for decision-making, they need cautious management and quality control. An information system is the collection of data, people, procedures, hardware, software, files, and data required to accomplish an organized set of functions.

The constituents of an information system are:

• People – those who gather data, those responsible for data input and those responsible for data analysis

• A storage / retrieval / analysis system – which consists of computer hardware and appropriate software

• A feedback delivery system – mechanisms to ensure that processed data are fed back to data gatherers

There are three types of disease occurrence namely, endemic, epidemic and outbreaks. Martin et al. (1993) described the term endemic as the disease occurrence in a predictable pattern. There can be low, moderate or high levels of endemicity. Although many times the terms epidemic and outbreak are used synonymously, the term epidemic is used when there is an unexpected incidence of a disease. Thrusfield (1995) defined an outbreak as the occurrence of a disease involving one or more animals.

Animal disease prevention and control activities offer valuable benefits for food production, food security and safety, animal and human welfare, and alleviation of poverty. The effectiveness of disease prevention and control policies depends on the good governance and quality of the veterinary services, in compliance with OIE standards and guidelines on animal disease control. The apex body in each country is the core system that takes care of the prevention and control of animal diseases. This body is responsible for early detection of diseases and rapid response to outbreaks. The veterinary services in developing countries require adequate human and financial resources and capacity building to carry out the tasks of disease prevention and control and to protect animal health and thus public health, including food security and food safety.

Programming techniques are used the mathematical tools by the scientists, economists, and planners to specify the optimum combination of resources and enterprises in farms and firms, to identify the profit maximizing mixes of commodities to be produced, to specify the cost minimizing methods of production and transportation of goods, to identify the least cost locations from which raw materials can be purchased, to determine the locations of production at which a particular commodity should be produced and the consumption centres to which it should be shipped, and to specify the least cost ingredients of a feed or ration which must meet the specified nutritional requirements. Programming techniques can be either linear or non-linear. Although several non-linear programming techniques (like quadratic, integer, separable, dynamic programming, etc., which are very complex to work with) are available, we will largely deal with linear programming technique and to a certain extent will brief the theory of dynamic programming.

An animal disease is an economic process in the farming system, as it consumes a considerable amount of scarce economic resources that would have been otherwise productively utilized by the animals and results in negative benefits to society. Hence, while measuring the losses attributable to animal diseases, the manifestation of such losses and the factors influencing such losses may also be identified, which require modelling the ways by which the negative effects of the diseases are exhibited. A description of such models and their procedures is essential to understand the comprehensive effects of diseases. We will list and describe such models and tools in this chapter.

11.1 CORRELATION ANALYSIS

While simple descriptive statistical tools are adequate to estimate the economic effects of animal diseases, these tools cannot measure the nature and strength of the relationships between two or more variables. However, the statistical knowledge can effectively be used to understand Various statistical measures studied so far, like measures of central tendency and dispersion and skewness, relate to one variable only. However, there are many situations where there are several problems involving the use of two or more variables. Although correlation analysis is only a bivariate technique like t-test, ANOVA, and Chi square test, we will briefly see about correlation in this chapter, as it is also a part of multivariate analysis. The first step is to determine which bivariate analytical tool we need to adopt to test the study hypothesis.

After assessing the prevalence or incidence of the disease concerned, the next step is to quantify the economic losses due to that disease by classifying and presenting all the information available on the losses, expressing these in monetary values, and identifying and quantifying the indirect losses attributable to a disease, to the extent possible. Usually, most of the negative effects of diseases can be conveniently estimated in terms of reduced output, mortality, reduced weight, delayed maturity, and treatment cost, directly. However, quantifying the indirect effects of the disease will be complex, but it is not impossible.

As we saw earlier, the economic impacts of animal diseases can be measured using statistical / epidemiological methods and economic methods. Economic methods of disease loss estimation include the Gross Margin Analysis, Enterprise Budgeting, Equi-Marginal Principle, Partial Budgeting, Cost Benefit Analysis, and Decision Analysis.

9.1 ECONOMIC LOSSES DUE TO ANIMAL DISEASES

Economic considerations are increasingly forcing their way forward in the decision-making processes of animal health management. With the continuing intensification of livestock production systems, the economic implications of livestock diseases have become increasingly important at both farm and national levels, as they represent avoidable waste of scarce resources (McInerney, 1988). From an economic point of view, an animal disease either destroys the basic resources, reduces the attainable output, dwindles the efficiency with which the resources are converted into products, or decreases the economic value of products (McInerney, 1995).

The effects of a disease present in an animal or herd may be manifested by stunted growth, lowered production, delayed maturity, delayed conception, mortality, reduced resource (especially feed) use efficiency, etc. These negative impacts of a disease demand more resource(s) than usual, resulting in higher expenditures for the same output and reduced farm income. Apart from these negative effects at the farm or herd level, animal diseases lead to economic losses at the regional, national, and global levels too by increasing animal mortality, reducing productivity, increasing disease control costs, swelling losses in animal trade, decreasing the market values of livestock and their products, and ultimately ending at food insecurity. These economic impacts of livestock diseases, besides their social impacts, have now been recognized globally, in both developed and developing countries, necessitating quantification of the economic impact of animal diseases as an urgent and important step to support the prevention and control decisions for improved animal health to ensure better rural and global economy.

8.1 NEED FOR ANIMAL DISEASE FREQUENCY MEASURES

The very essence of veterinary epidemiology is to measure animal disease occurrence and to make comparisons between the animal population groups. The animal disease frequency measures help us to understand the distribution of diseases in animal populations. Hence, the principal role of veterinary epidemiology is to describe and explain differences in the distribution of animal diseases between the populations.

Measures of the disease frequencies are used to describe how common an illness is concerning the size of the population (the population at risk) at a particular point in time. The major reason for determining the morbidity is to assess the extent of a disease problem in a population. This assessment is possible only when the number of diseased animals is calculated and compared with the total number of animals in the population. A report of 10 cases of mastitis in a dairy herd does not indicate the true extent of the disease problem, unless the report also indicates the total number of dairy animals in the herd or population. Thus, it is important to relate the number of cases of a disease to the population at risk of developing that disease.

Veterinary epidemiology is the study of disease within a livestock population, dealing with the investigation (including identification, quantification, and examination), of the direct and indirect determinants of disease distribution in animal populations. Any epidemiological investigation starts with whether there is an animal health problem in a population, which requires data collection on animal, management, economic, and environmental factors. These data are then analyzed descriptively to assess the frequency of disease occurrence. The results are then used to decide whether investigations of causal relationships between disease occurrence and potential risk factors are necessary for the development of control or prevention policies. Once the relationships are understood, necessary interventions for the disease are then planned and their impacts assessed. Hence, the goal of epidemiological investigations is the control and prevention of animal disease problems by integrating the available pieces of evidence into the decision-making process for disease control policy development.

A scientific experiment is a planned research to obtain new facts or to confirm or refute the results of previous experiments. Research is usually conducted in a controlled environment to study the effect of one or more variables on observations. The objective of research may be to answer a question, verify a hypothesis, or estimate the effect of an independent variable on a dependent variable. After stating the research problem, we need to outline the methodology (or materials and methods) of the research, which includes developing an experimental design.

Scientific experiments are conducted to study the causal relationships between independent variable(s) and dependent variable(s). The researcher manipulates one or more independent variables and measures their effect on one or more dependent variables. Designing an experiment is planning an experiment. It is a complete sequence of steps taken before experimenting to ensure that appropriate data are obtained to perform a data analysis to get valid inferences about the problem. It must be seen that the data collected are relevant to the problem investigated. E.g., studying the effect of breed, age, feed, etc. on milk output. Here, the objects like breed, age, feed, etc. are called treatments. That is, any specific experimental conditions (like the addition of feed additives, new feed formula, etc.) applied to the experimental units are called treatments. The basic objects on which the experiment is done are called experimental units (E.g., a bird, an insect, an animal). However, the responses in all the experimental units receiving the same treatments may not be similar, due to the inherent differences in the experimental units, called experimental error, caused by extraneous factors.

Before trying to understand Hypothesis Testing and Experimental Designs, we should be conversant with the concept of Probability Distribution.

5.1 PROBABILITY DISTRIBUTIONS

Let us look at an example to grasp the essence of a probability distribution. Let us rotate a pair of dice and observe the sum by totalling the numbers that turn upon in both the dice. Let us call this sum by a random variable X. When the first dice shows up number 1, the second dice could show 1, 2, 3, 4, 5, or 6. Likewise, when the first dice shows up number 2, the second dice could show 1, 2, 3, 4, 5, or 6. If we continue the experiment this way until all the possibilities are exhausted, the sample space will contain 36 elements. The distribution that can be observed will contain a sum = 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12. The starting sum will be = 2, because when both the dice show the number 1, the sum 1 + 1 = 2. Likewise, the maximum sum in the distribution will be 12, when both the dice show up a number 6. If we write the values of the random variable (sum) with associated probabilities, it is called a probability distribution.

For any statistical analysis, the required primary data are usually collected by the census or sampling methods. In the census method, the data are collected from all the individuals. E.g., If we want to study the weight of 100 cows, we have to make use of all 100 cows for data collection. That is, we collect data from the entire population or universe. However, in the sampling method, the data are collected from a small group of the population which is termed as the sample. A sample is a portion of the population selected to represent the population. E.g., we collect data only from a sample of cows, say 20 cows drawn from the population.

3.1 MEASURES OF CENTRAL TENDENCY (AVERAGES)

When data are presented in raw form or in the form of frequency distribution, they fail to provide a general idea of the data under study. The general idea of statistical methods is to condense the raw data into a form that can convey some meaningful characteristic(s) of the data. Though classification simplifies the data and improves the understanding of the main characteristics in the data, it is still difficult to remember. In any distribution of data, values of a variable may tend to cluster (or concentrate) around a central value. The data must be condensed into a single value. Such presentation of data is called a Central Tendency and the measures devised to consider this tendency are known as Measures of Central Tendency.

An average condenses a frequency distribution or raw data and presents it in a single representative number. It is that single value which is considered as the most representative or typical value for a set of values. Such a value usually lies somewhere near the centre of the group. That is why, an average is usually referred to as a measure of central tendency. It is located at a point around which most of the other values tend to cluster and therefore it is also termed as a measure of central location.

Statistics is defined as a discipline that includes procedures and techniques used to collect, process, and analyze numerical data to make inferences about the data. The word statistic is used as a singular, denoting the numerical data. Statistics are the numerical quantities calculated from sample observations. Here, the word statistics hence is plural. Basically, statistics is defined as the statistical data (in the plural sense) and also as statistical methods (in the singular sense). A clearer and more precise definition is that ‘statistics is the study of methods and procedures for collecting, classifying, presenting, analyzing, and interpreting data to make scientific inferences from it’. Bio statistics is the science dealing with the application of statistical methods to the problems of biological sciences.

2.1 FUNCTIONS OF STATISTICS

a) To present the facts in a definite form: If the data or results are given in numbers, rather than in qualitative statements, they will be more useful. The statements like ‘there is a considerable amount of unemployment in a country or the human population in a state is increasing at a faster rate’ are not in definite forms. The statements should be in definite form like there is a 15 percent unemployment in 2023 or the population is increasing by 5 percent every decade.

Human life on the earth has been intertwined with the fabric of crops and livestock for its sustenance, since time immemorial, for food and protection against the vagaries of nature. When agricultural and livestock production systems began to change in the 1950s, from traditional extensive systems to semi-intensive and intensive production systems, diseases of rural farm enterprises became challenging. Especially, the emerging diseases in livestock continued to demand more and more investments for ensuring food safety and security. Despite significant progress made in the recent past in reducing the prevalence of animal diseases, there is still an increasing concern over the losses associated with diseases of economic importance that result in production inefficiency. The scientific foundation for the discipline of animal health economics was laid by Morris (1969) and further steps were taken by Ellis (1972) to economically evaluate the Swine Fever eradication programme in Great Britain using cost-benefit analysis, Martin Hugh-Jones (1975) to specialize in GIS to model diseases and assessed the economic impact on production by infectious diseases, James and Ellis (1978) to use the same tool for FMD control programme, Renkema and Stelwagen (1979) to evaluate the replacement rates in dairy herds, Renkema (1980) to analyze the economic aspects of diseases in animals, Ellis and Putt (1981) to suggest the epidemiological and economic implications of FMD vaccination programme in Kenya, and McInerney (1983) to analyze the economics of animal diseases in dairy cattle, the multidisciplinary field of animal health economics was not amply exploited especially in developing countries to assess the extent of livestock disease losses (Ngategize and Kaneene, 1985).

Introduction

Virtual supply chain management is the digital representation of inventory data that the managers manage from anywhere in the world. In the 1980s, when the proliferation of computers gave more importance to the human resource, f inance, and manufacturing units communicating with each other for better quality work, that led to enterprise resource planning, and slowly each task of supply chain management started virtualizing in its full length.

A virtual supply chain has advantages such as better inventory control, shorter lead times, quicker order fulfilment, increased supply chain visibility, more accurate demand forecasts, and higher customer satisfaction. It gives businesses the ability to make the most use of their resources, cut expenses and lessen waste throughout the supply chain.

However, putting in place a virtual supply chain calls for thorough planning technology integration, and network-wide process alignment. Overcoming obstacles like data security, interoperability, and change management are all part of it. To fully reap the rewards of a virtual supply chain, businesses must also invest in technical infrastructure, training courses, and partnerships.

Introduction

Stocks from different firms can be traded and listed on the stock market. In addition, the stock market evaluates listed firms based on their worth, effectiveness, profitability, and capability. Anybody can trade shares on the stock market, which is an open global market. GDP is the total amount of profit produced in a country over a given period. To develop products and services in a country to a plausible degree, it is helpful to measure the monetary policy of completed goods and services that are acquired for a single end consumer. It comprises all earnings generated inside a country’s borders. The GDP of any nation may be used to determine the size and state of that nation’s economy. GDP is a measure of a nation’s total production and performance and is used as a gauge of economic health. Strong GDP growth frequently signals more consumer spending, corporate profitability, and company expansion, all of which are positive indicators of optimistic mood in the stock market. On the other hand, a slow GDP growth rate might undermine investor confidence and cause stock values to decline.