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Jaundice is a disease marked by a yellow discoloration in the skin, or in the whites of the eyes. This is due to excessive amounts of bile in the blood stream. Jaundice may arise from a number of different causes. Some types of jaundice arise from conditions outside the liver. Also in some cases the patient may have jaundice in a sub clinical form. That is, the bile pigment may be elevated but not sufficiently to actually discolour the skin.

Normally there is a certain rate at which the red blood cell are broken down and destroyed in the body. The average life of a red cell is about four months. But certain disease conditions may cause an excessive breakdown of red cells and this increases the bile pigment in the blood. Such a rapid breakdown of cells may be seen in haemolytic anaemia, sickle cell anaemia, pernicious anaemia, jaundice of the newborn child, as well as in malaria, pneumonia, yellow fever and certain bacterial infections of the blood.

Obstructive jaundice means that the bile is backing up into the blood stream because of some obstruction involving the larger bile ducts. The normal liver produces one pint of bile every twenty-four hours. This is transported to the gall bladder where it is concentrated and becomes green, or else passes directly to the small intestine where it acts as a lubricant. Bile is also necessary for the absorption of fats and for its laxative effect in the large intestine.

Worms and other intestinal parasites are found in every part of the world. They are more common in tropical and sub tropical areas and are more common during the rainy season. Most of these worms and parasites enter in the human body either through the mouth or through the skin of the feet.

Round worms, are the giant worms present in the intestines that cause the disease kwon as ascariasis. It is found in almost all the countries. These worms are off-white in colour, are long and thick and are most frequently seen in children. Eggs produced by them are passed in stools. When children play in the soil contaminated with the eggs, particularly children living under unhygienic conditions easily transfer them to the mouth via dirty fingers.

Roundworm eggs may remain alive in the soil for many months. There is always greater danger of contamination where human wastes are used in fertilizing vegetables. Great care must be taken to be sure all foods are thoroughly cleansed and sterilized by cooking before being used.

Inability to go to sleep or to get sleep for a period insufficient for the needs of an individual is known as insomnia. Chronic inability to sleep.

None of us can do without sleep. An infant sleeps 14 to 18 hours a day. This period is slowly reduced. An adult may be happy with 7 to 8 hours of sleep every night. There are people who require 5 hours or even 4 hours of sleep in 24 hours.

Sleep has a definite purpose and that is why all mammals sleep. Lack of sleep apparently does not cause any physical harm. But anyone who gets less than his normal sleep experiences a decrease of efficiency and concentration.

It is a contagious, infectious disease. It is of short duration usually sporadic, characterized by malaise, headache, severe pain in the body and catarrh of the respiratory passage.

Metrological conditions are predisposing causes. The bacillus of Pfeiffer is generally acknowledged to be the exciting cause. The bacilli enter the system through respiratory organs.

The disease is highly infectious. Incubation period is 1 or 2 days and one attack does not give any immunity, rather increases the susceptibility.

There is much discrepancy and disagreement among over authorities on the question. In a case of simple uncomplicated flu, but find no characteristic anatomical lesions other than congestion and catarrhal secretions of the mucous membranes of the respiratory and alimentary systems. Death is usually caused by some complication and post-mortems show all the changes found in the complicating diseases.

Many thousands of people today are heavy smokers, not by choice, but because they have found no way of escape. They are caught in the grip of a habit developed during their teen-age years when so many young people think it is 'smart' to smoke.

The strange thing is that most of these people never wanted to smoke in the first place. There was only doing what they thought everyone else was doing at the time. Yet there is another odd thing. Smoking in not a normal habit. A person has to learn to smoke.

Smoking is by and large, an acquired habit. People start smoking because they think it is fashionable to do so or because their friends and companions are able to persuade them to start smoking. Some smokers feel that they look more attractive to the opposite sex when they are smoking. Others hold that a social gathering becomes more intimate if people are smoking. In reality all this is a product of smokers imagination. Because he wants to justify his habit, he invents enough reasons for it.

Cholesterol is present in the diet of all people, and it can be absorbed slowly from the gastrointestinal tract into the intestinal lymph. It is highly fat soluble but only slightly soluble in water and is capable of forming esters with fatty acids.

Headache is the most common of all nervous complaints. The causes are varied and so also its mode of onset, duration, intensity and other conditions associated with it.

Structures of the head, which are sensitive to pain, are:

Inflammation of the mucous membrane of the stomach, sometimes accompanied by more or less severe constitutional manifestations.

Gastric Ulcer a well defined ulcer involving the mucous membrane of the stomach with a tendency to progressive destruction, beginning in the mucosa and sometimes extending to and even through the deeper layers of the walls of the stomach.

We have not been able to name a definite cause. "Altered composition of the blood and the resulting insufficient nourishment of the cells'⁷. Riegel says the ulcer is due "to a self-digestion of the stomach at the limited spot." He calls attention to the fact that the gastric juice is always hyperacid in these cases and thinks it is more than a mere coincidence. Virchow says the cause is emboli or thrombi, which form in the nutrient gastric arteries, which have lost their tonicity. He claims that an ulcer forms at the point of obstruction.

Gastric ulcers occur most frequently between twenty and thirty years of age. This is an average, which we arrive at from the fact that in females it is from fifteen to thirty and in males from forty to forty-five. The predominance of women over men as shown by clinical statistics is two to one, but pathologically the numbers are about equal in two sexes.

No occupation seems to grant exemption. Cooks seems to be more predisposed. Next come metal workers in those factories where there is much dust. Some claim that shoemakers and tailors are also prone to the condition.

The gall bladder is a small/pear shaped, muscular organ closely attached to the under surface of the liver. Its only function is to store and concentrate the bile between meals so there will be a plentiful supply when needed. Bile from the liver is a clear, golden colour when formed, but after being concentrated in the gall bladder it turns a deep green. This concentrating process sometimes results in the formation of stones in the gall bladder, particularly following pregnancy in commonly over weight women. Many people with gallstones seem to have no problem at all, especially if there is one large stone. But when a number of smaller stones are present in the gall bladder, the patient may feel sharp, cramp like pains all over the upper abdomen.

The predisposing causes are stagnation of bile, due to an excessive diet of starch and fat, constipation, obesity, pregnancy, tight lacing or other obstruction to the flow of bile.

The exciting causes are catarrhal and infective inflammation of the gall bladder, like sepsis, typhoid etc., and tumors. Old patients and women are most susceptible.

Eczema is a troublesome skin condition characterized by redness, cracking, oozing and scaling of the skin. Extremes of heat and cold and even emotional stress seem to play a part in this condition. The patient usually complains of itching and burning in the skin, especially at the night. Sores appear on various parts of the body, but most often on the hands, feet, ears and legs. Eczema may come on at any time of life and in either sex. The commoner manifestations are erythema changing to papule, vesicle, crust, scale and fissure, with serous exudation. In chronic cases, thick scales accumulate.

This is the effect of local irritation by chemical, thermal, actinic or mechanical agents in a hypersensitive individual, subject of an allergy or constitutional disabilities such as gout, chronic nephritis, rheumatism, local sepsis, dyspepsia, alcoholism, uterine disturbances also teething. In some cases heredity may be found.

Papules, vesicles and pustules with some degree of local oedema are found; exudation, crusting and scaling with inflammation of varying severity may be present. These tend to spread to the contiguous areas.

One or both cheeks of an infant or the ear, limbs or trunk are occasionally involved. In adults also similar papulo- vesicular eruptions appear. Sensations of burning, smarting, throbbing or itching are present, according to the acuteness of the process and severity of the inflammation.

Individuals suffering from the more pronounced types of mental disorder are sometimes said to be insane, but the term insanity is a legal one, not a medical term. An insane person is one who cannot distinguish right from wrong or assume responsibilities for his own actions. In the case of a psychotic patient the whole personality is involved. And he is completely out of touch with real world around. Not so the neurotic patient. Only a small part of his personality is involved. Psychotic patients often require hospitalization; neurotic patients rarely do, unless they have some additional physical problem.

Another distinction between these two major groups is that his friends usually bring the psychotic patient to the doctor, while the neurotic comes of his own accord. He knows he is sick, and he usually wants help. Most often he is suffering from a nervous depression.

The term dandruff includes several different conditions of the scalp. There is scaling in which the entire scalp may be covered with loose dry scales. When the hair is combed or brushed, or when the scalp is scratched, these scales fall like snow on the shoulders. Often there is itching, as well, and the scalp may be red from scratching.

What is at first thought to be dandruff may later prove to be some other conditions, such as. seborrhoeic dermatitis, or worse still psoriasis and even neurodermatitis.

Neurodermatitis : It is a chronic type of itching and inflammation of the skin. The itching area may be in some localized spot or it may extend over large areas of the body. The condition may even develop in infants. It may disappear after the age of two and return in the early teens of later. The condition is more often seen in those who suffer from fever, hives and asthma. True cause is not known for most of the people are allergic to many things. Many of them are tense and restless and are troubled with a dry skin. They are hypersensitive and are often given to itching, especially in the bend of elbow or behind the knee. The constant scratching leaves deep scratch marks and causes thickening and furrowing of the skin.

This is the commonest symptom of nearly all respiratory diseases and is indicative of an effort to expel a foreign substance causing irritation on any place in the cough reflex path.

The center is in the medulla close to the respiratory centers. This is activated reflexly by the afferent impulses traveling up mostly along the vagus and to a less extent, the vagus and the phrenic (to bronchi and diaphragm), the spinal accessory, intercostals and other nerves supplying the accessory muscles of respiration. The peripheral fibres of the vagus and the phrenic are also sometimes directly affected causing cough reflex.

The medullary center itself may also be excited or restrained by impulses from superior cerebella centers, so that cough may be induced or controlled by voluntary efforts.

Constipation means difficult or infrequent passage of the feces. In some cases it is due to mechanical obstruction of the intestines, such as cancer, diverticulitis, or perhaps to some functional cause, such as an irritable colon discussed above. In most cases there is no actual obstruction.

Many elderly people suffer from constipation; probably they do not take sufficient fluid. They may think they are drinking enough, but careful observation may reveal that they are having only two or three glasses of liquid a day. For normal bowel habits, one should drink from six to eight glasses of fluid each day.

Sometimes constipation results from ignoring the normal call of nature. Many people suffering from constipation become dependent upon laxatives in early childhood. This is most unfortunate, for it means that the child may be dependent on drugs for the rest of his life. As far as possible do not use an enema on a child unless absolutely necessary. Laxatives and enemas are only for unusual conditions. Nature will provide for the normal needs of the body.

Although the common cold affects all parts of the body, it usually begins in the nose and throat. Colds are so common we hardly give them a second thought, yet they can be rather serious. Most colds are due to virus infections of one type or another. Unfortunately, none of these viruses are susceptible to our present antibiotic medicines. Adenoviruses produce the more serious type of colds, and they are often followed by tonsillitis and sore throat even virus pneumonia, particularly in children. Sometimes the membranes of the eyes are also involved.

The common cold is the most prevalent of all diseases known to man. The average person seems to have two or three colds a year. The condition is highly contagious. When one member of the family has a cold, the others are very likely to have one within a few days.

What makes a person susceptible to a cold? Probably his lowered resistance is a chief factor. Allergic disorders of the nose and throat also make a person more susceptible to colds and other virus infections. Chilling of the body does seem to play a part, particularly in those whose resistance is already weak. Lack of sleep may be another factor.

Any person may carry the cold virus. However, children under six years of age seem readily to pass the infection from one to another, and soon all the family is involved. Colds are always more serious in the younger children.

It may be defined as a chronic condition of the liver in which there is an increase of the connective tissue, a decrease in its size, and a degeneration of the parenchyma.

Alcohol is the most common cause of the cirrhosis of liver. Alcohol reaches the liver through blood stream. Other causes may include improperly prepared foods, poisonous substances, drugs like arsenic, phosphorus, the infectious diseases like syphilis and obstruction of the bile ducts.

Cirrhosis of the liver produced by alcohol abuse is known as portal cirrhosis where as cirrhosis caused by some obstruction such as a stone in the common duct or some narrowing of the bile duct leading from the liver to the small intestine is called as Biliary cirrhosis.

Bronchitis may be defined as a distressing and often serious type of inflammation affecting the windpipe, or bronchial tubes, in the chest. There are two types of bronchitis:

1. Acute Bronchitis
2. Chronic Bronchitis

Acute bronchitis: In acute bronchitis the larynx, trachea and bronchial tubes are acutely inflamed. The tissues are swollen because of irritation; large amount of mucus is secreted and poured into the bronchial tubes to protect the inflamed mucous membrane. Unless this thick, sticky material is removed, it may obstruct the windpipe, causing more severe diseases like atelactasis and pneumonia. The common cold is probably the most frequent cause of acute bronchitis.

During the acute stage of bronchitis there is usually a high fever and some difficulty in breathing. There is a constant cough. Hoarseness may also be present and some pain in the chest. Difficulty in breathing continues until the inflammation has decreased. And thick secretions have removed. Chilliness is present with internal coldness, also cold hands and feet, rawness beneath the sternum, some tightness and oppression of the chest, cough may be dry, hard, ringing, expulsive, paroxysmal, tearing which leaves great soreness under the sternum. After few days the cough, which was at first dry, becomes moist and is accompanied by slight expectoration of mucus and occasionally some blood. As the amount of expectoration increases all the other symptoms decreases, and then in turn abnormal secretion and expectoration also decreases at the end of 7 to 10 days.

By the time a child reaches the age of two he can usually keep himself dry during the day. However, it may be another year or more before he can keep dry all through the night. Even then, the best-trained child may fail to live up to expectations on certain occasions when he is highly excited.

Older boys and girls may also have occasional problems at night, especially when sleeping in a strange bed after a highly exciting evening.

The bladder is emptied unconsciously especially during sleep at night; may be associated with enlarged tonsils, thyroid deficiency, phimosis, intestinal worms, blanitis or vulvitis also sometimes pyelitis, cystitis, oxaluria even minor epilepsy.

There are many causes for this condition, ranging all the way from simple neglect of the calls of nature to degenerative changes in the spinal cord. The condition is found in all classes and at all ages. Nocturnal bedwetting is very common in weak, neurotic children. The next most numerous class is that of women who have born children and who have passed the fiftieth milestone. A laugh, a sneeze, a fright and the urine spurt from the bladder. Probably this is want of proper adjustment of the function of the nervous mechanism of the sphincter and the detrusor and the former fails to inhibit the later.

Partial or complete loss of hair on the scalp is rather common among them. This is more or less to be expected in the female. Premature baldness is a tendency in certain families. Thinning of the hair is often seen in older women, but complete baldness in the female is fortunately rare. Temporary baldness may occur following a fever or some prolonged illness. The hair usually returns after the patient has recovered from the illness.

Sudden loss of the hair in certain areas, a condition called alopecia areata, may sometimes follows extreme nervous shock. This may clear up in a few weeks, although sometimes it will recur. In females excessive hair loss is seen after delivery and during lactation. This is only due to hormonal changes in the body and due to suckling of the milk by the child. This disappears after the child stops weaning. It is not a permanent problem. In children falling of hair occurs due to many reasons such as severe headache, dim eyesight, after a prolonged illness, use of different shampoos and soaps, after a severe head injury and a familial tendency. Generally it is observed that if the parents have thin hair and early loss of hair in their life so is their children.

Many people use various shampoos and creams to prevent hair loss but with no gain. Homoeopathy has a very good treatment for hair loss. Some of the important medicines indicated in the hair loss are given below:

Asthma is a condition of sudden paroxysmal, expiratory, wheezing dyspnoea caused by an abnormal response of the respiratory center to stimulus causing hyperactivity of the vagal endings in the broncho-constricting muscles resulting in bronchial spasm; with it, hyperaemia oftlte mucous membrane followed by excessive bronchial secretion is associated.

This is true spasmodic asthma and in this other conditions of periodic expiratory dyspnoea with a different primary factor should not be included.

The disease has in most a family history and is more common in males; sometimes found in young children but more frequently begins in early adult life. Some of these have definite bronchitis also but in the most, the main is paroxysmal bronchospasm no physical sign obtained in the lungs.

The factors concerned in asthma are (i) bronchospasm from causes central and peripheral, (ii) oedema of the bronchial mucous membrane from allergy. Neuropathic predisposition.

The more immediate causes are (i) allergy, (ii) peripheral stimuli from their site of production, grouped as (a) naso-pharyngeal, (b) alimentary, (c) endocrine (d) broncho-pulmonary (iii) constitutional disturbances.

For ages, man has consumed alcohol to forget his sorrows, to lead him into the realm of happiness. John Keats (1795 -1821), the great romantic English poet, listened to the full-throated music of a nightingale and wanted to become one with that moment of happiness. He thought of taking 'a beaker full of the warm south, of vintage, that has been cooled a long age in the deep delved earth⁷, drinking which he could ' leave the world unseen', and fade away into the dim forest with the singing bird. But Keats was romanticizing the effect of wine on the human mind. A moment later, he decided to give up the idea of taking the assistance of Bacchus and his leopards and switched over to reaching the bird and its music on 'the viewless wings of poesy⁷. This was definitely a wise decision because the alleged euphoric effect on alcohol is a myth. In fact alcohol dulls the brain and retards its activity.

Alcohol is basically a drug. Man consumes it more than any other drug. No form of alcohol, however mild, whether wine or beer or cider, can do good to the human system and health.

It is fallacy to believe that alcohol stimulates the brain. In reality, alcohol depressed the brain. It slows down various centers of control. When alcohol is swallowed, it goes into the stomach where a fraction of the dose enters the blood stream through the blood vessels of the stomach walls. From the stomach, alcohol has to pass into the small intestine. The carbon dioxide in soda water accelerates this flow of alcohol from the stomach into the intestines. This is what makes whisky and soda more dangerous than whisky and water.

Pimples are very common in young people during their teen years. This condition, which is also known as acne, is apparently due to certain hormone changes in the body. It is particularly prevalent during early adolescence, from 12 to 16 years of age, and is more likely to occur in those who have an oily skin. In the early stages a blackhead or comedone blocks the outlet of an oil gland within the skin. This is not a serious problem, for it leaves no permanent effect.

If the sebaceous duct ruptures and the oily material ooze out between the layers of the skin instead of coming to the surface, there may be a cyst or swelling known as a sebaceous cyst. These are somewhat disfiguring, but not harmless unless they become infected and form small abscesses. When these heal they may leave ugly scars. Severe acne may occur on the shoulders, the back and chest, as well as the face and neck.

Effects of diet: Acne is not caused by diet, but certain foods definitely aggravate this condition, especially in some patients. Rich foods, such as chocolate, nuts, cola drinks, ice-cream, fatty meats, and excessive amount of sugar, all seem to aggravate this condition. Certain drugs, such as those containing bromides and iodides, may also play a part in some people.

Some girls develop one to two pimples just before menstruation. These only last a day or two and are of no consequence. But when acne continues over months or years, it is very distressing, especially to a young woman, and something should definitely be done to clear up the condition. Nervous tension due to family trouble may also play a part in continuing this difficult problem. Even in its mildest form, acne usually persists for a year or more until the hormone system of the body has become fully adjusted.

This chapter provides a readily available means of reference for helping in life threatening emergencies, accidents and for providing first aid, where any delay caused by the lack of medication or non-availability of the doctor can have serious consequences either in terms of life or in terms of resulting serious sickness.

As soon as possible competent medical help should be availed of in emergencies and accidents. In the meanwhile the homoeopathic medicines suggested hereafter would provide relief, would halt deterioration in most cases and may save life in many instances.

Emergencies can be life threatening. One of these can be severe haemorrhage, where copious bleeding can lead to death. Obstruction of breathing for different reasons is a matter for concern. Serious accidents are life threatening because there may be unmanageable bleeding, shock and pain.

Below, a list of few medicines and other items required for first aid in emergencies has been given. This can be helpful in homes, in factories and offices.

Homoeopathy system of medicine is the system of healing suited to all the young, and the old, the rich and the poor, the people in the developed as well as the underdeveloped countries and for persons in any place or climate. This is not to take away from the value and utility of the other prevalent systems of medicine. The aim of every science of healing is the relief of sick. Every system is successful in its own fashion. Homoeopathy too fights sickness and does so with remarkable results. Additionally the cost of diagnosis in this system is negligible because the diagnosis is by and large symptomatic. The medicine itself is inexpensive. Notable efficacy and low costs are the strong points of homoeopathic medicine. There are no toxic effects of the drugs, no side effects. The time taken for the medicine to show improvement is not long. Homoeopathic medicines are easy to store and have a long life.

Homoeopathy has been attacked again and again on the ground that the potencised drugs cannot be tested in a laboratory. But that way a number of phenomenon is still outside the pale of conventional science. However, laboratory tests have been going in many countries and certain phenomenon not acceptable to conventional scientific beliefs have been observed.

The homoeopathic system of medicine develops for its special use, the inner medicinal powers of the crude substances by means of a process peculiar to it and which has never been tried, whereby they only all become immeasurably and penetratingly efficacious and remedial. Even those that in the crude state give no evidence of the slightest medicinal power on the human body.

This remarkable change in the qualities of natural bodies develops the latent, hidden powers, which influence the body, change the well-being. This is affected by mechanical action upon their smallest particles by means of rubbing and shaking and through the addition of an indifferent substance, dry or fluid. This process is called dynamization; potencizing and the products are dynamizations or potencies in different degrees.

The homoeopathic materia medica consists of around 1000 drugs, the characteristics of which have been verified or proved. Homoeopathy is unique in that it uses no drug, which has not been proved. The proving has been done by administering pure medicines to healthy human beings and recording in minute detail the effects, mostly adverse, produced by such administration. The tests were conducted on men and women who were mostly medical people and students who were not sick. The drugs were administered in doses consisting of crude drugs or homoeopathic potencies. These volunteers were then asked to describe the effects of the drugs in their own words. These descriptions were noted down by the doctors conducting the experiments and were carefully recorded. Hundreds of thousands of such symptoms were recorded while proving the homoeopathic drugs and the materia medica forms a record of the best proving along with other data collected as a result of laboratory tests and experiments.

In paragraph 25 of the 'Organon of medicine', Dr.Samuel Hahnemann the founder of the system laid down the basis of homoeopathy in the following words: "Now, however, in all careful trials, pure experience, the sole and infallible oracle qi healing art, teaches us that medicine which, in its action on the healthy human body, has demonstrated its power of producing the greatest number of symptoms similar to those observable in the case of disease under treatment, does also, in doses of suitable potency and attenuation, rapidly, radically and permanently remove the totality of the symptoms of this morbid state, that is to say the whole disease present, and change it into health; and that all medicines cure, without exception, those diseases whose symptoms most nearly resemble their own, and leave none of them uncured."

Homoeopathic treatment is based on an overall understanding of the symptoms in the body and mind created by a sickness. Dr. Samuel Hahnemann, the founder of the homoeopathic science of healing, after years of experiment and trial, came to finding that symptom - similarity is the curative method of medically curable diseases. In paragraph 25 of the 'Organon of Medicine⁷, he formulated the principle of 'like cures like' in these words: " Now, however, in all careful trials, pure experience, the sole and infallible oracle of the healing art, teaches us that actually that medicine which, in its action on the healthy human body, has demonstrated its power of producing the greatest number of symptoms similar to those observable in the case of disease under treatment, does also, rapidly, radically and permanently remove the totality of the symptoms of this morbid state, that is to say, the whole disease present, and change it into health; and that all medicines cure, without exception, those diseases whose symptoms most really resemble their own, and leave none of them uncured."

The aforesaid indicates the importance of symptoms in the diagnosis and treatment in homoeopathy. If a drug creates a symptom during the course of proving, then it can be cured by a potencised dose of the drug; whatever may be the name of the disease. For instance, in proving GLONOINE produces a bursting, throbbing sensation in the head in a healthy person. Conversely any surging of the blood to the head requires GLONOINE. This can happen in a sun - stroke, in high blood pressure, in cerebro - spinal meningitis. KALI BICROMICUM produces in proving, a tough, stringy discharge of mucus. In homoeopathy, KALI BICROMICUM cures a similar discharge whether from the nose inwards from mouth, from fauces, from pharynx, from larynx, trachea, bronchi, vagina, and uterus or from any mucus membrane. CACTUSGRANDIFLORUS produces in pure form and gross doses, constriction of the heat and a constriction, anywhere in the body, which is like an iron band being tightened. The same sensation of constriction leads us to the use of CACTUS in a homoeopathic dose and it need not be confined to the heart. There can be constriction of the scalp, in the oesophagus, in the chest, in the abdomen, bladder, uterus, vagina or rectum.

This individualizing examination of a case of disease, for which Dr. Hahnemann give general directions, of which the practitioner will bear in mind only what is applicable for each individual case, demands of the physician nothing but freedom from prejudice and sound senses, attention in observing and fidelity in tracing the picture of the disease.

The patient details the history of his sufferings; those about him tell what they heard him complain of, how he has behaved and what they have noticed in him; the physician sees, hears, and remarks by his other senses what there is of an altered or unusual character about him. He writes down accurately all that the patient and his friends have told him in the very expressions used by them. Keeping silence himself, he allows them to say all they have to say, and refrains from interrupting them (every interruption breaks the train of thought of the narrators, and all they would have said at first does not again occur to them in precisely the same manner after that.) unless they wander off to other matters. The physician advises them at the beginning of the examination to speak slowly, in order that he may take down in writing the important parts of what the speaker says.

He begins a fresh line with every new circumstance mentioned by the patient or his friends, so that the symptoms shall be all ranged separately one below the other. He can thus add to any one that may at first have been related in too vague a manner but subsequently more explicitly explained.

Dr. Samuel Hahnemann laid down the fundamentals of the then new doctrine of homoeopathy in organon of medicine. As observed by him in the 'Introduction⁷ to this work, till then no one had ever taught this homoeopathic mode of cure, no one had carried it out in practice.

Dr. Hahnemann was of the view that the art of the medical practice "should. Rapidly and mildly, effect an unalloyed and permanent cure, and restore to health by means of the smallest doses of a few simple medicines carefully selected according to their proved effect, by the only therapeutic law comfortable to nature, that is Similia Similibus Curentur".

Homoeopathy is based on the following principles:

"The physicians high and only mission is to restore the sick to health, to cure, as it is termed"

The highest ideal of cure is rapid, gentle and permanent restoration of health or removal and annihilation of the disease in its whole extent in the shortest, most reliable and most harmless way on easily comprehensible principles.

Unprejudiced observer of a sick person takes note of nothing in every individuars disease except the changes in the health of the body and of the mind, which can be perceived externally by means of the senses. "All these perceptible signs represent the disease in its whole extent, that is, together they form the true and only conceivable portrait of the disease"

The homoeopathic system of medicine is one of the finest systems of cure available in the world. It achieves in totality the ideal laid down by its founder, Dr. Samuel Hahnemann:

"The highest ideal of cure is rapid, gentle and permanent restoration of the health, or removal and annihilation oftlie disease in its whole extent, in the shortest, most reliable, and most harmless way, on easily compreltensible principles".

In homoeopathy, not a single drug is used without knowing its effect on healthy human beings. Hence there is no shooting in the dark. The system operates, by and large, without laboratory tests and other expensive means of diagnosis, which are being used when not needed and that too, unfortunately on patients who can hardly afford the expenses.

Cost wise, there is no medical system in tlie world, which is as inexpensive as homoeopathy. No patient who requires a speedy cure without side effects can ignore homoeopathy; no doctor who has nothing but the good of his patient at heart can overlook the utility and effectiveness of homoeopathy and no Government which has to balance its budget can afford not to use homoeopathy in hospitals and other institutions run for the health and care of the sick and thus it is the most cost effective treatment

The discovery of homoeopathic system of medicine makes a fascinating story.

8.1 Black Pepper Breeding

Black pepper (Piper nigrum L., family:Piperaceae), known as the ‘King of Spices’ and “Black gold”, is one of the important spices since time immemorial and perhaps the oldest spice regarded globally. It is a perennial climber grown for its fruits that are used as spice with plethora of medicinal properties. Black pepper is also very important in traditional medicine (Ravindran, 2000). However, it is mainly valued for its characteristic pungency and flavour, as an ingredient in food preparations and also as a condiment.

Genetic Resources

World’s largest collection of black pepper germplasm is maintained by the Indian Institute of Spices Research (IISR) at Kozhikode, Kerala, containing local cultivars, wild forms collected from the area of origin and related species. At present there are about 3466 accessions, consisting of 1266 wild relatives, 2062 cultivars, in addition to 9 exotic collections maintained in India. These collections were characterized and evaluated to estimate the genetic diversity for various yield and quality characters. Cultivar diversity is one of the principal components of diversity in black pepper. The cultivars are evolved directly from the wild P. nigrum.

7.1 Plant Tissue Culture

Spices have great socio-economic impact in moden food habit of human but loss of resources day by day due to various reasons (industrialization, high population pressure) make the access of these valuable spices limited to people. Low production is general phenomena of common spices due to lack of high yielding varieties. Hence there is a need to improve the propagation method to meet the gap between demand and supply. Conventional vegatative propagation method is common approach for propagation but low multiplication rate, seasonal dependency and susceptible to abiotic stresses and diseases are major problems to achieve the optimum productivity. To overcome these drawbacks scientists have chosen the plant tissue culture technique (a modern approach of biotechnology which deals with the propagation the valuable/endangered plants under laboratory condition). Details about this technique and its role on spices are given below.

Plant Tissue Culture: Basic Components and Objectives

The technique of growing of a whole plant cell, tissue or organ under an aseptic condition in suitable synthetic medium is termed as plant tissue culture (Thorpe, 2007). De-differentiation and re-differentiation are two essential fundamental processes which help in the physio-morphological development of the plant.

6.1 Introduction

Plant breeding is the indispensible component of elevating production and productivity of spices by evolving high yielding and/or with good quality type. Thereby, the practice of identification and selection of desirable traits and introgression of those characters in a single plant is being done since the beginning of organized agricultural activities by humankind. The act of plant breeding was reshaped and got a momentum with a scientific basis after the discovery and rather rediscovery of Mendel’s laws. Worldwide, humankind could enjoy the direct benefits of methodical plant breeding during green revolution. Manipulation of genetic architecture for creating variation in the population and successive selection is the basic of all kinds of crop breeding. But the process of creation of variability and selection differs from crop to crop depending on their mode of reproduction. It is comparatively easier to get a new homogeneous population in self pollinating plants. Therefore, segregating generations are handled differently in these two categories of self and cross pollinated crops.

Pollination

Pollination is the act of transfer of pollen from the male reproductive organ of a plant to the female reproductive organ of same or another plant.

Pollination is of two types

5.1 Self Pollination

It is the transfer of pollen from the anther to the stigma of the same flower from where the anthers have been generated. Thus, self pollination happens to be denominated as autogamy where auto means “same” and gamy means “union”. Obviously, self pollination is found in bisexual flowers. But self pollination also occurs when pollen is transferred from one bisexual flower to the stigma of another bisexual flower of the same plant. This kind of autogamy is known as geitonogamy. So, self pollination has to be defined keeping the parent plant on the main focus not the flower. If genetical consequences are considered, self pollination promotes the occurance of purelines or homozygotes. Self pollinating species developed themselves evolutionary fit due to homozygous balance and do not exhibit significant inbreeding depression.

Cultivated plants in general including the spice crops observed today have been evolved through selections from their weedy and wild types. Apart from this, there had been another force which could bring the wild forms into cultivated forms named human intervention which is actually the process of domestication. Natural mutations and genetic recombination after selfing and crossing also played a significant role in the entire process. Whereas, natural forces take a long time to come into act, the techniques of plant breeding was devised and fine tuned throughout passing of times, essentially to accelerate the speed of evolution using these natural phenomenons. It was, therefore, mandatory for us to know the modes of reproduction and pollination to create variability in natural population and make all thise happen to what we see today in organised cultivated forms. Moreover, knowledge on reproduction of different plant species helps the breeder to choose the right breeding procedure to be used for crop improvement. Modes of reproduction help to evaluate the genetic constitution of crop plants by determining the extent of homozygosity or heterozygosity which, in turn, are unanimously applicable to any plant. To comprehend modes of reproduction in spice crops effectively, understanding about the floral biology is absolutely necessary. Plant reproduction, a process by which one species gives birth to its offsprings, may be of two types

Since historical times, Indian spices have been contributed not only to the country’s wealth and prosperity but also to the subcontinent itself as a whole. Spices precisely witnessed many wars, bloodshed, armoury alongwith the glowing accounts and adventurous voyage by Pliny, Ptolemy, Marco Polo, Vasco da Gamma and other travelers. The Southern parts of India, especially the Malabar Coast, with its abundance of the World’s best pepper, cinnamon and ginger was enormously creating impact of a plethora of spices which attracted the foreign trade and continue even today by creating a unique brand value globally. In the past, invaders travelled to India by overcoming many odds and barriers with the prime focus on capturing spice trade and dominating the trade scenario of those days throughout the world. As a result, gradually Indian spices travelled far and wide to traditional destinations by providing flavor, aroma, pungency, taste and colour to a variety of foods and beverages.

It was the end of 18^th century, from when scientific research began on the idea of origin of cultivated plants. The pioneers of this field were Darwin, Alphonse de Candolle, N.I Vavilov and many more. Charles Darwin wrote his famous book ‘On the Origin of Species by Means of Natural Selection’, or the ‘Preservation of Favoured Races in the Struggle for Life’ published on 24^th November 1859. According to him, cultivated plants may have originated from its wild form after a series of intense modifications. Afterwards, a Swiss botanist Alphonse de Candolle studied 247 cultivated plant species and documented his work in the book “Origin of cultivated plants” in 1886. Later, Vavilov first identified the Centres of origin. He could determine the origin of plants by analyzing the pattern of variation and proposed that, crop plants have been evolved from their wild species in the geographic region of the greatest genetic diversity of that particular plant. That area is known as the primary centres of origin of the particular plant. But, some crop species were found to show substantial genetic diversity even though they did not originate there. Such areas are known as secondary centres of origin for that particular species.

A. General Morphology

2.1 The Root

It is the organ of a plant that typically lies below the surface of the soil.The root is best defined as the non-leaf, non-nodes bearing parts of the plant’s body. However, important internal structural differences between stems and roots exist. Root spices are, rather surprisingly, rare. Some popular examples of spices having roots are: Apium graveolens (Celery), Armoracia rusticana (Horse radish), Coriandrum sativum (Coriander), Ferula asafoetida (Asafetida), Glycyrrhiza glabra (Licorice), Levisticum officinale (Lovage), (Petroselinum crispum (Parsley), etc. All of the mentioned plants have aromatic roots.Roots of gingiberaceae are adventitious and storage roots arise from among the nodes of these scales.

Plant breeding is described as an art and science of changing the genetic architecture of plants with a goal towards betterment of mankind. Apart from this generalized concept, plant breeding is accomplished through inter-disciplinary mode assorted from simple selection in a variable plant-population having some desirable traits to the application of biotechnology and more. Worldwide, cultivars of different crops are routinely manufactured by Multinational and National level Industries, Government Institutions, Universities, Crop specific Organizations, professional plant breeders and even by the individuals such as gardeners and farmers.

Plant breeding is basically operated by the principles of Genetics where selections are practiced from a variable population and the selected variation needs to be inherited. Three categorized broad goals of plant breeding are 1) high yield 2) uplift in quality and 3) resistance against biotic and abiotic stress.

Spice crops are known to add nutritive value and increase the palatability as well as quality of food. Therapeutic uses of spices are also well recognised. The spice industry in India and trade has shown stunning progress over the last 5 years with 120% increase in revenue which is very close to touch $ 3 billion. East Asia is the major market for spices, followed by America and the European Union and the world spice trade has almost touched $ 17 billion by 2020. So, increased production is of paramount importance across the world and the potential is increasing. On the other hand, quality improvement is one of the primary objectives of spice crop breeding apart from achieving high yield. Cultivar and species diversity are the principal components of diversity of spices (Sasikumar et al. 1999; Krishnamoorthy et al., 1997; Prasath and Venugopal, 2004). A good amount of variability is found in many important Indian spices like black pepper, cardamom, cinnamon, curry leaf, ginger, garcinia, tamarind and turmeric. A number of cultivars have been released followed by intra-germplasm evaluation and selection in spices. Contribution of recombination breeding is less in spice crops with regard to other field crops and a number of valuable varieties have been bred by clonal and seedling selection (Peter, 2008). Deployment of high yielding, water use efficient, climate resilient genotypes and technologies are also necessary.

The biofertilizer technology has paved way for the manufacturers and entrepreuners to establish a biofertilizer production unit due to an increasing demand and awareness among farmers. Biofertilizer production units have already been started with most of them in the southern states of India. The biofertilizers can be produced using different kinds of carrier materials (peat, coal, lignite, clays, inorganic soil), organic materials (composts, soybean meal, wheat bran, sawdust, etc.), or inert materials (e.g., vermiculite, perlite, kaolin, bentonite, silicates). Natural carriers like peat, plant waste materials, composts, sawdust, sludge lignite, clays, coal, vermiculite, perlite and bentonite and mixture of organic and inorganic materials may also be used.

The Government of India is also encouraging a low cost technology by providing a subsidy to establish a biofertilizer production unit . The major equipment’s and other materials required for a biofertilizer production unit with the capacity of 150 metric tonnes/annum are given below

There are many manufacturers of biofertilizers in both government and private sectors. Only some of them have been listed here for the information

The soil fertility is depleting in the current scenario of gap between nutrient removal from soil and supplies. Moreover, increase in the fertilizer prices has become unaffordable to small and marginal farmers. There is also a growing concern about the environmental hazards and its threat to sustainable crop production. Indiscriminate use of synthetic fertilizers for intensive crop production has resulted in large quantity of nutrient (particularly P) accumulation in soils which has resulted in generating a dead soil. In this context, the long term use of biofertilizers are considered to be economical, eco-friendly, more efficient, productive and accessible to marginal and small farmers over chemical fertilizers (Subba Rao, 2001). Biofertilizers mainly consists of specific living cells which supplies nutrients to plants through their root system. Microbes in these fertilizers provide nutrients to the plants by nitrogen fixation, phosphate solubilization, phosphate mobilization, and promotion of beneficial rhizobacteria (Bhat et al., 2010). Biofertilizer application improves the supply of nutrients, organic carbon, accumulation of soil enzymes, productivity, soil fertility index, economy of farmers, and maintenance of sustainability in natural soil ecosystem and horticultural crops. The production of efficient and sustainable biofertilizers for crop plants needs to be undertaken to make the biofertilizers popular and efficient. The important and specific research in future may be focused on the following aspects.

Microbes present in the biofertilizer formulations help in microbial processes in the soil which augment the availability of nutrients to be taken up by plants. They are of different types based on their nature and function such as nitrogen fixing, phosphate solubilizing, phosphate mobilizing or biofertilizers for micronutrients. Plants use different strategies for growth promotion at different stages of plant growth and development. Biofertilizers are mass multiplied cultures of specific beneficial microbial strains which improves the fertility of soil and productivity. The nutrients are added through natural processes of nitrogen fixation, solubilization of phosphorus and synthesis of growth promoting substances to stimulate the plant growth. The main sources of biofertilizers are bacteria, fungi and cyanobacteria.

11.1. Bio-enrichment of chemical fertilizers- A new approach

Yield response of different host plant depends on the mineral fertilizer and its fertilizer use efficiency. Generally, such fertilizers are low in efficiency due to environmental and soil factors. A large portion of synthetic fertilizers are lost due to fixation, leaching, run-off, erosion, volatilization, denitrification and precipitation without reaching plants. Hence, there is an economic loss and water and environmental pollution.

Microbial inoculants applied to the soil enhances the uptake of nutrient by plants and increase the efficiency of synthetic or organic fertilizers. In this context, it is possible to impregnate mineral fertilizers with specific microbial strain. A new approach is to incorporate the microbes or microbial compositions into fertilizer compositions.

It has been well established that the biofertilizers are beneficial to plants and are cost-effective inputs for sustainable production system. However, there are some constraints with respect to its production, which are presented below:

10.1 Production constraints

10.1.1 Raw material

Eventhough there are large number of biofertilizer formulations, only few are considered as good carrier materials for biofertilizers such as peat and lignite. Moreover, its availability in India is limited and the quality is lacking for these carrier materials. Hence, a cost effective and locally available material with increased shelf-life is the need of the hour.

10.1.2 Specificity and availability of strains

As the microbial strains used as biofertilizers are specific to soil and agro-ecological conditions, availability of specific strains for the specific host and soil edaphic factors are inadequate.

Quality Control is very important in biofertilizer production, which determines the efficiency of microbial strains. Generally, the quality control based on BIS are voluntary in nature. However, some of the biofertilizers are brought under the ambit of Fertilizer Control Order 1985 (FCO) during 2006 (Yadav and Chandra, 2014). At present, biofertilizers are under the FCO with specific quality standards. Biofertilizer production and its sales can be regulated and is a mandatory requirement for registration of manufacturing unit with the State Fertilizer Controller (who is generally the Commissioner or Director of Agriculture Department) under the statutory provision of FCO. Moreover, some officers of the Agriculture Department have been declared as Fertilizer Inspectors at the district level, who are authorized to inspect production and storage facilities and draw samples for quality analysis. National Centre of Organic Farming (NCOF), Ghaziabad under the Govt. of India and its six Regional Centre’s located at Bhubaneswar, Bangalore, Jabalpur, Nagpur, Hissar and Imphal have been declared as testing laboratories. Under the provisions of the FCO act, State Governments can also develop their own quality control laboratories and notify them under the FCO (1985). Peat, lignite, peat soil, humus, wood charcoal or similar material favouring the growth of microbial strain could also be used. The FCO specifications for different biofertilizers are presented below:

Biofertilizer is already proven to be beneficial for agricultural and horticultural crops. The most important pre-requisite for the success of biofertilizer application is the presence of high population of viable cells which will show the desired effect on plants. Biotic interactions along with competition from native microflora is a major challenge to an applied strains of biofertilizers. The formulation is an important parameter for biofertilizer production containing efficient microbial strain with suitable carrier material and additives. The microbial strain needs suitable protective environment to increase their efficiency at the target site and also make it user-friendly. Performance of biofertilizers under field condition is the major requirement for inoculants. Inadequate formulations and poor inoculant quality are the major hurdles for the successful use of biofertilizers.

Formulation of biofertilizers has to be consistant during production, distribution, storage and transport to the farmer/end users. The shelf-life of inoculated microbial fertilizer depends on the formulation with suitable carrier material. If local production and distribution of an efficient native biofertilizer formulations are developed, the present problems in the field performance of biofertilizers could be significantly solved. Specific formulations of native strains for use in saline soils, acid soils, drought, high temperature and eroded soils requires specific formulations. Therefore,use of native strains of biofertilizer formulations which are tolerant to the abiotic stress is an important approach. The formulations of biofertilizers are challenging and limited success has been observed in the commercialization of new biofertilizers. Hence, the search for new formulations has been a continuous approach. However, the choice of the formulation depends on the application method, available equipment, farmer’s convenience, plant inherent characteristics and developmental stage, cost, mode of action and colonization pathway of the inoculated strain. Conventionally, solid based formulations are used, which have problems of low viability during storage and application.

Biofertilizers can directly or indirectly influence the growth of plant. The direct influence can be through production of phytohormones or making the nutrients available to plants. The indirect effect can be through management of plant pathogens through biological control. Therefore, the purposeful introduction of biofertilizer inoculants to plant microbiome represents an environmentally sound option that holds a prominent position in order to reduce the dependency on agrochemicals (Adesemoye and Kloepper, 2009; Abhilash et al., 2016; Aloo, et al., 2019).

Microbes in soil can rarely exists as single cells and survive near the plant root canopy or in bulk soils or endophytes or even on plant surfaces (Lorito, 2006). The soil microflora occurs as complex members of microbiota (Hacquard, 2015). Microbial consortia (MC) are unique mixture of organisms which respond to the environment stress and adapt to stresses due to internal beneficial interactions among the microbial community. Ecosystem’s physiological functions by microflora is carried out by more than one microbial species with the functional diversity and succession among different microbial components. The microbial balance among the different microflora of a MC will consist of a continuous shift between actively growing cells and non-dividing cells of the microbial consortia. It has been reported that different microbial populations “talk” to each other by “quorum sensing” mechanism in a given environment by exchanging specific chemical signals (Thompson, 2015). Natural microbial consortia holds many specific properties like stability, functional diversity and perform complex functions. The natural consortia have generated an interest in manpulating synthetic consortia for the benefit of application (Minty, et al., 2013).

Fruits, vegetables, ornamentals, plantation crops and spices, medicinal and aromatic plants, tubers, are the major horticultural crops contributing to the economic growth in India. Even though the horticultural sector is growing fast, with India being the second largest producer of fruits and vegetables in the world, the productivity and quality have to be improved in order to meet the demand of increasing population. Under these circumstances, ecofriendly techniques needs to be adopted which could ensure food security and sustainable production. Indiscriminate application of agrochemicals and chemical fertilizers in horticultural crops and their residues could harm the human health, soil and environment. Horticultural crops need an ecofriendly technique, as most of the horticultural products are directly consumed. Hence, there should not be any residues of agrochemicals in food products. In the current context, use of ecofriendly, cost effective and organic-based inputs like biofertilizers can maintain health of the soil and good quality in horticultural crops. The application of biofertilizers offers an attractive and sustainable means of improving the quality of food products. Biofertilizers like Azotobacter, Azospirillum and AMF and PGPRs not only supplies the required nutrients to plants, but improves the fruit quality and quantity (Pathak et al., 2017).

The inoculum dosage and method of application determines the efficacy of biofertilizers. The quantity of biofertilizers to be applied depends on the type of crop, seed rate and soil edaphic factors. There are 3 methods for inoculation of biofertilizers

Seed treatment: One packet containing inoculant (200 g) is mixed with 200 ml of rice gruel or 40 % gum arabic solution to make a slurry (Fig. 23). Then the seeds required for an acre are mixed in the slurry in such a manner that they have a uniform coating of the inoculant over the seeds. Then, the inoculated seeds are shade dried for 30 minutes. The shade dried seeds should be sown within 24 hours. One packet of the inoculant (200 g) is normally sufficient to treat 10 kg of seeds.

Benefit of biofertilizers have been extensively studied for various agricultural and horticultural crops. However, the effectiveness of inoculated biofertilizers are influenced by several factors. If the use of biofertilizers have to be popularized in horticultural crops, the major factors affecting their performance particularly in relation to soil, plant, quality of the product and application methods have to be addressed. Factors affecting the performance of biofertilizers are:

4.1 Quality of the product

4.1.1 Production process

The high quality of biofertilizers are determined by the production process (Bashan et al., 2014). At the same time, the population density of mother culture and the quality of the final products are directly related (Stephens and Raskm, 2000). As the inoculum consists of a strain, the relationship among the microorganisms interaction in the rhizosphere have to be understood. In the case of more than one microorganisms, the efficiency depends on the various mode of action by various microorganisms which might overlap with antagonistic acitivities (Vassilev et al., 2001, 2006 b). The relationship of microorganisms with plants is not based on the taxonomic diversity, but their functional diversity (Maherali and Klironomos, 2007).

The efficiency of biofertilizers could be assured by enhanced shelf life of the inoculant and biological traits which are a challenge for developing a formulation (Bashan, et al., 2014). Hence, either single or consortia of microorganisms formulation with or without additives determines the efficacy of the biofertilizers. The formulation determines shelf-life during storage and transport, which enhances the persistence of the strain in soil and get maximum benefits to the host plants after inoculation (Manikandan et al., 2010; Schoebitz et al., 2012). Different kinds of carriers are used in the formulation process which affects the overall quality and efficacy of the biofertilizers (Bashan et al., 2014; Herrmann and Lesueur, 2013). Granular inoculants showed good results under stressed soil conditions (Clayton et al., 2004; Lupwayi et al., 2006). Encapsulation of the microbial strain into polymers allow diverse compositions and structures (Vassilev et al., 2005) but, have limitations for commercial production (Bashan, et al., 2014; John et al., 2011). Use of additives might improve the shelf life of the product (Bashan et al., 2014; Malusà et al., 2012; Herrmann and Lesueur, 2013) with introduction of specific substances to enhance the efficacy of biofertilizers.

Biofertilizers improve the plant growth due to changes in the microbial community of rhizosphere by production of several substances. Normally, biofertilizers promote plant growth either by facilitating nutrient absorption or by secretion of plant hormones. Biofertilizers also cause inhibitory effects by acting as biocontrol agents on various pathogens so that the growth of plant is enhanced. The mode of action could be either direct or indirect methods